Opposite causal effects of birthweight on myocardial infarction and atrial fibrillation and the distinct mediating pathways: a Mendelian randomization study

Opposite causal effects of birthweight on myocardial infarction and atrial fibrillation and the distinct mediating pathways: a Mendelian randomization study

Abstract Background Previous observational studies have documented an inverse association of birthweight with myocardial infarction (MI) but a positive association with atrial fibrillation (AF). However, the causality of these associations and the underlying mediating pathways remain unclear. We aim...

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Bibliographic Details
Main Authors: Lijie Kong, Yiying Wang, Chaojie Ye, Chun Dou, Dong Liu, Min Xu, Jie Zheng, Ruizhi Zheng, Yu Xu, Mian Li, Zhiyun Zhao, Jieli Lu, Yuhong Chen, Weiqing Wang, Ruixin Liu, Yufang Bi, Tiange Wang, Guang Ning
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Cardiovascular Diabetology
Subjects:
Atrial fibrillation
Birthweight
Body composition
Cardiometabolic factors
Mediation
Mendelian randomization
Online Access:https://doi.org/10.1186/s12933-023-02062-5

Internet

https://doi.org/10.1186/s12933-023-02062-5

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