Exosomal Non-Coding RNAs: New Insights into the Biology of Hepatocellular Carcinoma
Exosomes, extracellular vesicles with a diameter of 40 to 160 nm, are among the smallest extracellular vesicles released by cells. They deliver different cargoes, including proteins, DNAs, and RNAs, and facilitate communication between cells to coordinate a variety of physiological and pathological...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/29/8/427 |
| _version_ | 1827628699889958912 |
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| author | Qian Zhang Hanlin Li Yang Liu Jian Li Chunling Wu Hua Tang |
| author_facet | Qian Zhang Hanlin Li Yang Liu Jian Li Chunling Wu Hua Tang |
| author_sort | Qian Zhang |
| collection | DOAJ |
| description | Exosomes, extracellular vesicles with a diameter of 40 to 160 nm, are among the smallest extracellular vesicles released by cells. They deliver different cargoes, including proteins, DNAs, and RNAs, and facilitate communication between cells to coordinate a variety of physiological and pathological functions. Hepatocellular carcinoma (HCC) is the sixth common malignant tumor and the fourth leading cause of cancer-related death worldwide. Its molecular mechanism remains largely unknown, and there is a lack of reliable and noninvasive biomarkers for early diagnosis and prognosis prediction. Mounting evidence has shown that exosomes carry a variety of ncRNAs, such as long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), which play critical roles in the occurrence and progression of HCC. In this review, we summarize the recent findings of exosomal miRNAs, lncRNAs, and circRNAs in HCC from their impact on the development of HCC to their potential applications in the diagnosis and treatment of HCC. |
| first_indexed | 2024-03-09T13:36:06Z |
| format | Article |
| id | doaj.art-767f39ce0fa44ae0b0c762cac0a6ccd9 |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-09T13:36:06Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-767f39ce0fa44ae0b0c762cac0a6ccd92023-11-30T21:11:33ZengMDPI AGCurrent Oncology1198-00521718-77292022-07-012985383540610.3390/curroncol29080427Exosomal Non-Coding RNAs: New Insights into the Biology of Hepatocellular CarcinomaQian Zhang0Hanlin Li1Yang Liu2Jian Li3Chunling Wu4Hua Tang5School of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, ChinaSchool of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, ChinaSchool of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, ChinaSchool of Basic Medical Sciences, Chengdu University, Chengdu 610106, ChinaSchool of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, ChinaSchool of Basic Medical Sciences, Southwest Medical University, Luzhou 646000, ChinaExosomes, extracellular vesicles with a diameter of 40 to 160 nm, are among the smallest extracellular vesicles released by cells. They deliver different cargoes, including proteins, DNAs, and RNAs, and facilitate communication between cells to coordinate a variety of physiological and pathological functions. Hepatocellular carcinoma (HCC) is the sixth common malignant tumor and the fourth leading cause of cancer-related death worldwide. Its molecular mechanism remains largely unknown, and there is a lack of reliable and noninvasive biomarkers for early diagnosis and prognosis prediction. Mounting evidence has shown that exosomes carry a variety of ncRNAs, such as long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), which play critical roles in the occurrence and progression of HCC. In this review, we summarize the recent findings of exosomal miRNAs, lncRNAs, and circRNAs in HCC from their impact on the development of HCC to their potential applications in the diagnosis and treatment of HCC.https://www.mdpi.com/1718-7729/29/8/427exosomehepatocellular carcinomalong non-coding RNAmicroRNAtumor microenvironment |
| spellingShingle | Qian Zhang Hanlin Li Yang Liu Jian Li Chunling Wu Hua Tang Exosomal Non-Coding RNAs: New Insights into the Biology of Hepatocellular Carcinoma Current Oncology exosome hepatocellular carcinoma long non-coding RNA microRNA tumor microenvironment |
| title | Exosomal Non-Coding RNAs: New Insights into the Biology of Hepatocellular Carcinoma |
| title_full | Exosomal Non-Coding RNAs: New Insights into the Biology of Hepatocellular Carcinoma |
| title_fullStr | Exosomal Non-Coding RNAs: New Insights into the Biology of Hepatocellular Carcinoma |
| title_full_unstemmed | Exosomal Non-Coding RNAs: New Insights into the Biology of Hepatocellular Carcinoma |
| title_short | Exosomal Non-Coding RNAs: New Insights into the Biology of Hepatocellular Carcinoma |
| title_sort | exosomal non coding rnas new insights into the biology of hepatocellular carcinoma |
| topic | exosome hepatocellular carcinoma long non-coding RNA microRNA tumor microenvironment |
| url | https://www.mdpi.com/1718-7729/29/8/427 |
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