Pneumonic-type invasive mucinous adenocarcinoma and infectious pneumonia: clinical and CT imaging analysis from multiple centers
Abstract Background Pneumonic-type invasive mucinous adenocarcinoma (IMA) was often misdiagnosed as pneumonia in clinic. However, the treatment of these two diseases is different. Methods A total of 341 patients with pneumonic-type IMA (n = 134) and infectious pneumonia (n = 207) were retrospectivel...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | BMC Pulmonary Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12890-022-02268-5 |
| _version_ | 1797985421050773504 |
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| author | Shuai Zhang Xinxin Yu Yong Huang Pei Nie Yan Deng Ning Mao Sha Li Baosen Zhu Li Wang Bo Wang Ximing Wang |
| author_facet | Shuai Zhang Xinxin Yu Yong Huang Pei Nie Yan Deng Ning Mao Sha Li Baosen Zhu Li Wang Bo Wang Ximing Wang |
| author_sort | Shuai Zhang |
| collection | DOAJ |
| description | Abstract Background Pneumonic-type invasive mucinous adenocarcinoma (IMA) was often misdiagnosed as pneumonia in clinic. However, the treatment of these two diseases is different. Methods A total of 341 patients with pneumonic-type IMA (n = 134) and infectious pneumonia (n = 207) were retrospectively enrolled from January 2017 to January 2022 at six centers. Detailed clinical and CT imaging characteristics of two groups were analyzed and the characteristics between the two groups were compared by χ2 test and Student’s t test. The multivariate logistic regression analysis was performed to identify independent predictors. Receiver operating characteristic curve analysis was used to determine the diagnostic performance of different variables. Results A significant difference was found in age, fever, no symptoms, elevation of white blood cell count and C-reactive protein level, family history of cancer, air bronchogram, interlobular fissure bulging, satellite lesions, and CT attenuation value (all p < 0.05). Age (odds ratio [OR], 1.034; 95% confidence interval [CI] 1.008–1.061, p = 0.010), elevation of C-reactive protein level (OR, 0.439; 95% CI 0.217–0.890, p = 0.022), fever (OR, 0.104; 95% CI 0.048–0.229, p < 0.001), family history of cancer (OR, 5.123; 95% CI 1.981–13.245, p = 0.001), air space (OR, 6.587; 95% CI 3.319–13.073, p < 0.001), and CT attenuation value (OR, 0.840; 95% CI 0.796–0.886, p < 0.001) were the independent predictors of pneumonic-type IMA, with an area under the curve of 0.893 (95% CI 0.856–0.924, p < 0.001). Conclusion Detailed evaluation of clinical and CT imaging characteristics is useful for differentiating pneumonic-type IMA and infectious pneumonia. |
| first_indexed | 2024-04-11T07:17:48Z |
| format | Article |
| id | doaj.art-7680443b2834407781f6fe5ddaa1e086 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-04-11T07:17:48Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-7680443b2834407781f6fe5ddaa1e0862022-12-22T04:37:52ZengBMCBMC Pulmonary Medicine1471-24662022-12-012211910.1186/s12890-022-02268-5Pneumonic-type invasive mucinous adenocarcinoma and infectious pneumonia: clinical and CT imaging analysis from multiple centersShuai Zhang0Xinxin Yu1Yong Huang2Pei Nie3Yan Deng4Ning Mao5Sha Li6Baosen Zhu7Li Wang8Bo Wang9Ximing Wang10School of Medicine, Shandong First Medical UniversityShandong Provincial Hospital, Shandong UniversityShandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical SciencesDepartment of Radiology, The Affiliated Hospital of Qingdao UniversityDepartment of Radiology, Qilu Hospital, Shandong UniversityDepartment of Radiology, Yantai Yuhuangding Hospital, Affiliated Hospital of Qingdao UniversityShandong Provincial Hospital, Shandong UniversityShandong Provincial Hospital, Shandong UniversityPhysical Examination Center, Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityDepartment of Anesthesiology, Shandong Provincial Hospital, Shandong UniversityDepartment of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong UniversityAbstract Background Pneumonic-type invasive mucinous adenocarcinoma (IMA) was often misdiagnosed as pneumonia in clinic. However, the treatment of these two diseases is different. Methods A total of 341 patients with pneumonic-type IMA (n = 134) and infectious pneumonia (n = 207) were retrospectively enrolled from January 2017 to January 2022 at six centers. Detailed clinical and CT imaging characteristics of two groups were analyzed and the characteristics between the two groups were compared by χ2 test and Student’s t test. The multivariate logistic regression analysis was performed to identify independent predictors. Receiver operating characteristic curve analysis was used to determine the diagnostic performance of different variables. Results A significant difference was found in age, fever, no symptoms, elevation of white blood cell count and C-reactive protein level, family history of cancer, air bronchogram, interlobular fissure bulging, satellite lesions, and CT attenuation value (all p < 0.05). Age (odds ratio [OR], 1.034; 95% confidence interval [CI] 1.008–1.061, p = 0.010), elevation of C-reactive protein level (OR, 0.439; 95% CI 0.217–0.890, p = 0.022), fever (OR, 0.104; 95% CI 0.048–0.229, p < 0.001), family history of cancer (OR, 5.123; 95% CI 1.981–13.245, p = 0.001), air space (OR, 6.587; 95% CI 3.319–13.073, p < 0.001), and CT attenuation value (OR, 0.840; 95% CI 0.796–0.886, p < 0.001) were the independent predictors of pneumonic-type IMA, with an area under the curve of 0.893 (95% CI 0.856–0.924, p < 0.001). Conclusion Detailed evaluation of clinical and CT imaging characteristics is useful for differentiating pneumonic-type IMA and infectious pneumonia.https://doi.org/10.1186/s12890-022-02268-5Invasive mucinous adenocarcinomaInfectious pneumoniaComputed tomographyLung disease |
| spellingShingle | Shuai Zhang Xinxin Yu Yong Huang Pei Nie Yan Deng Ning Mao Sha Li Baosen Zhu Li Wang Bo Wang Ximing Wang Pneumonic-type invasive mucinous adenocarcinoma and infectious pneumonia: clinical and CT imaging analysis from multiple centers BMC Pulmonary Medicine Invasive mucinous adenocarcinoma Infectious pneumonia Computed tomography Lung disease |
| title | Pneumonic-type invasive mucinous adenocarcinoma and infectious pneumonia: clinical and CT imaging analysis from multiple centers |
| title_full | Pneumonic-type invasive mucinous adenocarcinoma and infectious pneumonia: clinical and CT imaging analysis from multiple centers |
| title_fullStr | Pneumonic-type invasive mucinous adenocarcinoma and infectious pneumonia: clinical and CT imaging analysis from multiple centers |
| title_full_unstemmed | Pneumonic-type invasive mucinous adenocarcinoma and infectious pneumonia: clinical and CT imaging analysis from multiple centers |
| title_short | Pneumonic-type invasive mucinous adenocarcinoma and infectious pneumonia: clinical and CT imaging analysis from multiple centers |
| title_sort | pneumonic type invasive mucinous adenocarcinoma and infectious pneumonia clinical and ct imaging analysis from multiple centers |
| topic | Invasive mucinous adenocarcinoma Infectious pneumonia Computed tomography Lung disease |
| url | https://doi.org/10.1186/s12890-022-02268-5 |
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