Editorial: Utility of protein aggregation assays from laboratory to clinical application

Editorial: Utility of protein aggregation assays from laboratory to clinical application

Bibliographic Details
Main Author:	Alison Jane Ellen Green
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-08-01
Series:	Frontiers in Aging Neuroscience
Subjects:	RT-QuIC PMCA seed amplification assays prion disease α-synuclein
Online Access:	https://www.frontiersin.org/articles/10.3389/fnagi.2022.998136/full

Similar Items

RT-QuIC and Related Assays for Detecting and Quantifying Prion-like Pathological Seeds of α-Synuclein
by: Ankit Srivastava, et al.
Published: (2022-04-01)

High diagnostic performance of independent alpha-synuclein seed amplification assays for detection of early Parkinson’s disease
by: Marco J. Russo, et al.
Published: (2021-11-01)

Evolution of Diagnostic Tests for Chronic Wasting Disease, a Naturally Occurring Prion Disease of Cervids
by: Nicholas J. Haley, et al.
Published: (2017-08-01)

Are We Ready for Detecting α-Synuclein Prone to Aggregation in Patients? The Case of “Protein-Misfolding Cyclic Amplification” and “Real-Time Quaking-Induced Conversion” as Diagnostic Tools
by: Silvia Paciotti, et al.
Published: (2018-06-01)

Cerebrospinal fluid lipoproteins inhibit α-synuclein aggregation by interacting with oligomeric species in seed amplification assays
by: Giovanni Bellomo, et al.
Published: (2023-04-01)

Essential Components of Synthetic Infectious Prion Formation De Novo
by: Kezia Jack, et al.
Published: (2022-11-01)

Defining the Protein Seeds of Neurodegeneration using Real-Time Quaking-Induced Conversion Assays
by: Matteo Manca, et al.
Published: (2020-08-01)

Autoclave treatment fails to completely inactivate DLB alpha-synuclein seeding activity
by: Jung-Youn Han, et al.
Published: (2023-07-01)

The Future of Seed Amplification Assays and Clinical Trials
by: Thomas Coysh, et al.
Published: (2022-06-01)

Chronic Wasting Disease: State of the Science
by: Jason C. Bartz, et al.
Published: (2024-02-01)

Pathological α-synuclein detected by real-time quaking-induced conversion in synucleinopathies
by: Juan Huang, et al.
Published: (2024-03-01)

Kinetic parameters of alpha-synuclein seed amplification assay correlate with cognitive impairment in patients with Lewy body disorders
by: Stefan Bräuer, et al.
Published: (2023-10-01)

The Latest Research on RT-QuIC Assays—A Literature Review
by: Thi-Thu-Trang Dong, et al.
Published: (2021-03-01)

Real-Time Quaking- Induced Conversion Assays for Prion Diseases, Synucleinopathies, and Tauopathies
by: Sarah Vascellari, et al.
Published: (2022-03-01)

Detection of skin α-synuclein using RT-QuIC as a diagnostic biomarker for Parkinson’s disease in the Chinese population
by: Jiaqi Li, et al.
Published: (2024-02-01)

Seed amplification assays for diagnosing synucleinopathies: the issue of influencing factors
by: Giovanni Bellomo, et al.
Published: (2021-11-01)

α-Synuclein conformers reveal link to clinical heterogeneity of α-synucleinopathies
by: Matthias Schmitz, et al.
Published: (2023-03-01)

Recombinant PrP and Its Contribution to Research on Transmissible Spongiform Encephalopathies
by: Jorge M. Charco, et al.
Published: (2017-12-01)

Detection of Chronic Wasting Disease Prions in Fetal Tissues of Free-Ranging White-Tailed Deer
by: Amy V. Nalls, et al.
Published: (2021-12-01)

Prion Seeds Distribute throughout the Eyes of Sporadic Creutzfeldt-Jakob Disease Patients
by: Christina D. Orrù, et al.
Published: (2018-12-01)

Diagnosing multiple system atrophy: current clinical guidance and emerging molecular biomarkers
by: Meghana Goolla, et al.
Published: (2023-09-01)

Alpha-synuclein seeding shows a wide heterogeneity in multiple system atrophy
by: Ivan Martinez-Valbuena, et al.
Published: (2022-02-01)

Preclinical Detection of Alpha-Synuclein Seeding Activity in the Colon of a Transgenic Mouse Model of Synucleinopathy by RT-QuIC
by: Jung-Youn Han, et al.
Published: (2021-04-01)

Clinical application of prion-like seeding in α-synucleinopathies: Early and non-invasive diagnosis and therapeutic development
by: Jiaqi Li, et al.
Published: (2022-10-01)

Application of α-Syn Real-Time Quaking-Induced Conversion for Brain and Skin Specimens of the Chinese Patients With Parkinson’s Disease
by: Dong-Dong Chen, et al.
Published: (2022-07-01)

Detection of Prions in Brain Homogenates and CSF Samples Using a Second-Generation RT-QuIC Assay: A Useful Tool for Retrospective Analysis of Archived Samples
by: Tibor Moško, et al.
Published: (2021-06-01)

New protocol for kinetic assay seeding ability recovery “KASAR” from formalin-fixed paraffin-embedded tissues
by: Monica Hepker, et al.
Published: (2023-01-01)

Potential sources of interference with the highly sensitive detection and quantification of alpha‐synuclein seeds by qRT‐QuIC
by: Viktoria C. Ruf, et al.
Published: (2020-05-01)

Efficient RT-QuIC seeding activity for α-synuclein in olfactory mucosa samples of patients with Parkinson’s disease and multiple system atrophy
by: Chiara Maria Giulia De Luca, et al.
Published: (2019-08-01)

Novel histotypes of sporadic Creutzfeldt–Jakob disease linked to 129MV genotype
by: Laura Cracco, et al.
Published: (2023-08-01)

Tau seed amplification assay reveals relationship between seeding and pathological forms of tau in Alzheimer’s disease brain
by: Bryan Frey, et al.
Published: (2023-11-01)

Effect of the micro-environment on α-synuclein conversion and implication in seeded conversion assays
by: Niccolo Candelise, et al.
Published: (2020-01-01)

Formalin RT-QuIC assay detects prion-seeding activity in formalin-fixed brain samples from sporadic Creutzfeldt–Jakob disease patients
by: Thi-Thu-Trang Dong, et al.
Published: (2021-11-01)

Association between CSF alpha-synuclein seeding activity and genetic status in Parkinson’s disease and dementia with Lewy bodies
by: Kathrin Brockmann, et al.
Published: (2021-10-01)

Validation and Application of Skin RT-QuIC to Patients in China with Probable CJD
by: Kang Xiao, et al.
Published: (2021-12-01)

Identification of chronic wasting disease prions in decaying tongue tissues from exhumed white-tailed deer
by: Paulina Soto, et al.
Published: (2023-10-01)

Evaluation of Real-Time Quaking-Induced Conversion, ELISA, and Immunohistochemistry for Chronic Wasting Disease Diagnosis
by: Carine L. Holz, et al.
Published: (2022-01-01)

Sensitive detection of chronic wasting disease prions recovered from environmentally relevant surfaces
by: Qi Yuan, et al.
Published: (2022-08-01)

Pathologic and biochemical characterization of PrPSc from elk with PRNP polymorphisms at codon 132 after experimental infection with the chronic wasting disease agent
by: S. Jo Moore, et al.
Published: (2018-03-01)

Optimization of RT-QuIC Assay Duration for Screening Chronic Wasting Disease in White-Tailed Deer
by: Gokhan Yilmaz, et al.
Published: (2024-02-01)