Deubiquitinating Enzyme-Mediated Signaling Networks in Cancer Stem Cells
Cancer stem cells (CSCs) have both the capacity for self-renewal and the potential to differentiate and contribute to multiple tumor properties, such as recurrence, metastasis, heterogeneity, multidrug resistance, and radiation resistance. Thus, CSCs are considered to be promising therapeutic target...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/11/3253 |
| _version_ | 1797548883620921344 |
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| author | Kamini Kaushal Suresh Ramakrishna |
| author_facet | Kamini Kaushal Suresh Ramakrishna |
| author_sort | Kamini Kaushal |
| collection | DOAJ |
| description | Cancer stem cells (CSCs) have both the capacity for self-renewal and the potential to differentiate and contribute to multiple tumor properties, such as recurrence, metastasis, heterogeneity, multidrug resistance, and radiation resistance. Thus, CSCs are considered to be promising therapeutic targets for cancer therapy. The function of CSCs can be regulated by ubiquitination and deubiquitination of proteins related to the specific stemness of the cells executing various stem cell fate choices. To regulate the balance between ubiquitination and deubiquitination processes, the disassembly of ubiquitin chains from specific substrates by deubiquitinating enzymes (DUBs) is crucial. Several key developmental and signaling pathways have been shown to play essential roles in this regulation. Growing evidence suggests that overactive or abnormal signaling within and among these pathways may contribute to the survival of CSCs. These signaling pathways have been experimentally shown to mediate various stem cell properties, such as self-renewal, cell fate decisions, survival, proliferation, and differentiation. In this review, we focus on the DUBs involved in CSCs signaling pathways, which are vital in regulating their stem-cell fate determination. |
| first_indexed | 2024-03-10T15:06:09Z |
| format | Article |
| id | doaj.art-7685eeb6c33e4cccba48c191194f2dd4 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T15:06:09Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-7685eeb6c33e4cccba48c191194f2dd42023-11-20T19:45:06ZengMDPI AGCancers2072-66942020-11-011211325310.3390/cancers12113253Deubiquitinating Enzyme-Mediated Signaling Networks in Cancer Stem CellsKamini Kaushal0Suresh Ramakrishna1Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul 04763, KoreaGraduate School of Biomedical Science and Engineering, Hanyang University, Seoul 04763, KoreaCancer stem cells (CSCs) have both the capacity for self-renewal and the potential to differentiate and contribute to multiple tumor properties, such as recurrence, metastasis, heterogeneity, multidrug resistance, and radiation resistance. Thus, CSCs are considered to be promising therapeutic targets for cancer therapy. The function of CSCs can be regulated by ubiquitination and deubiquitination of proteins related to the specific stemness of the cells executing various stem cell fate choices. To regulate the balance between ubiquitination and deubiquitination processes, the disassembly of ubiquitin chains from specific substrates by deubiquitinating enzymes (DUBs) is crucial. Several key developmental and signaling pathways have been shown to play essential roles in this regulation. Growing evidence suggests that overactive or abnormal signaling within and among these pathways may contribute to the survival of CSCs. These signaling pathways have been experimentally shown to mediate various stem cell properties, such as self-renewal, cell fate decisions, survival, proliferation, and differentiation. In this review, we focus on the DUBs involved in CSCs signaling pathways, which are vital in regulating their stem-cell fate determination.https://www.mdpi.com/2072-6694/12/11/3253cancer stem cellsdeubiquitinating enzymesDUB inhibitorssignalingstemness |
| spellingShingle | Kamini Kaushal Suresh Ramakrishna Deubiquitinating Enzyme-Mediated Signaling Networks in Cancer Stem Cells Cancers cancer stem cells deubiquitinating enzymes DUB inhibitors signaling stemness |
| title | Deubiquitinating Enzyme-Mediated Signaling Networks in Cancer Stem Cells |
| title_full | Deubiquitinating Enzyme-Mediated Signaling Networks in Cancer Stem Cells |
| title_fullStr | Deubiquitinating Enzyme-Mediated Signaling Networks in Cancer Stem Cells |
| title_full_unstemmed | Deubiquitinating Enzyme-Mediated Signaling Networks in Cancer Stem Cells |
| title_short | Deubiquitinating Enzyme-Mediated Signaling Networks in Cancer Stem Cells |
| title_sort | deubiquitinating enzyme mediated signaling networks in cancer stem cells |
| topic | cancer stem cells deubiquitinating enzymes DUB inhibitors signaling stemness |
| url | https://www.mdpi.com/2072-6694/12/11/3253 |
| work_keys_str_mv | AT kaminikaushal deubiquitinatingenzymemediatedsignalingnetworksincancerstemcells AT sureshramakrishna deubiquitinatingenzymemediatedsignalingnetworksincancerstemcells |