Network-Based Single-Cell RNA-Seq Data Imputation Enhances Cell Type Identification

Single-cell RNA sequencing is a powerful technology for obtaining transcriptomes at single-cell resolutions. However, it suffers from dropout events (i.e., excess zero counts) since only a small fraction of transcripts get sequenced in each cell during the sequencing process. This inherent sparsity...

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Bibliographic Details
Main Authors: Maryam Zand, Jianhua Ruan
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Genes
Subjects:
Online Access:https://www.mdpi.com/2073-4425/11/4/377