Opioid epidemic and liver disease
Summary: Opioid use in the United States and in many parts of the world has reached epidemic proportions. This has led to excess mortality as well as significant changes in the epidemiology of liver disease. Herein, we review the impact of the opioid epidemic on liver disease, focusing on the multif...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-09-01
|
| Series: | JHEP Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589555919300783 |
| _version_ | 1818297607008550912 |
|---|---|
| author | Elizabeth C. Verna Aaron Schluger Robert S. Brown, Jr. |
| author_facet | Elizabeth C. Verna Aaron Schluger Robert S. Brown, Jr. |
| author_sort | Elizabeth C. Verna |
| collection | DOAJ |
| description | Summary: Opioid use in the United States and in many parts of the world has reached epidemic proportions. This has led to excess mortality as well as significant changes in the epidemiology of liver disease. Herein, we review the impact of the opioid epidemic on liver disease, focusing on the multifaceted impact this epidemic has had on liver disease and liver transplantation. In particular, the opioid crisis has led to a significant shift in incident hepatitis C virus infection to younger populations and to women, leading to changes in screening recommendations. Less well characterized are the potential direct and indirect hepatotoxic effects of opioids, as well as the changes in the incidence of hepatitis B virus infection and alcohol abuse that are likely rising in this population as well. Finally, the opioid epidemic has led to a significant rise in the proportion of organ donors who died due to overdose. These donors have led to an overall increase in donor numbers, but also to new considerations about the better use of donors with perceived or actual risk of disease transmission, especially hepatitis C. Clearly, additional efforts are needed to combat the opioid epidemic. Moreover, better understanding of the epidemiology and underlying pathophysiology will help to identify and treat liver disease in this high-risk population. |
| first_indexed | 2024-12-13T04:22:07Z |
| format | Article |
| id | doaj.art-7689368596524d2fa486ade97ab19048 |
| institution | Directory Open Access Journal |
| issn | 2589-5559 |
| language | English |
| last_indexed | 2024-12-13T04:22:07Z |
| publishDate | 2019-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JHEP Reports |
| spelling | doaj.art-7689368596524d2fa486ade97ab190482022-12-21T23:59:46ZengElsevierJHEP Reports2589-55592019-09-0113240255Opioid epidemic and liver diseaseElizabeth C. Verna0Aaron Schluger1Robert S. Brown, Jr.2Center for Liver Disease and Transplantation, Columbia University Vagelos College of Physicians and Surgeons, New York, NY; Corresponding author. Address: Director of Clinical Research, Transplant Clinical Research Center, Center for Liver Disease and Transplantation, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY 10032; Tel.: 212-305-0662.Columbia University Vagelos College of Physicians and Surgeons, New York, NYCenter for Liver Disease and Transplantation, Columbia University Vagelos College of Physicians and Surgeons, New York, NY; Division of Gastroenterology and Hepatology, Weill Cornell Medicine, New York, NYSummary: Opioid use in the United States and in many parts of the world has reached epidemic proportions. This has led to excess mortality as well as significant changes in the epidemiology of liver disease. Herein, we review the impact of the opioid epidemic on liver disease, focusing on the multifaceted impact this epidemic has had on liver disease and liver transplantation. In particular, the opioid crisis has led to a significant shift in incident hepatitis C virus infection to younger populations and to women, leading to changes in screening recommendations. Less well characterized are the potential direct and indirect hepatotoxic effects of opioids, as well as the changes in the incidence of hepatitis B virus infection and alcohol abuse that are likely rising in this population as well. Finally, the opioid epidemic has led to a significant rise in the proportion of organ donors who died due to overdose. These donors have led to an overall increase in donor numbers, but also to new considerations about the better use of donors with perceived or actual risk of disease transmission, especially hepatitis C. Clearly, additional efforts are needed to combat the opioid epidemic. Moreover, better understanding of the epidemiology and underlying pathophysiology will help to identify and treat liver disease in this high-risk population.http://www.sciencedirect.com/science/article/pii/S2589555919300783 |
| spellingShingle | Elizabeth C. Verna Aaron Schluger Robert S. Brown, Jr. Opioid epidemic and liver disease JHEP Reports |
| title | Opioid epidemic and liver disease |
| title_full | Opioid epidemic and liver disease |
| title_fullStr | Opioid epidemic and liver disease |
| title_full_unstemmed | Opioid epidemic and liver disease |
| title_short | Opioid epidemic and liver disease |
| title_sort | opioid epidemic and liver disease |
| url | http://www.sciencedirect.com/science/article/pii/S2589555919300783 |
| work_keys_str_mv | AT elizabethcverna opioidepidemicandliverdisease AT aaronschluger opioidepidemicandliverdisease AT robertsbrownjr opioidepidemicandliverdisease |