Synthesis, Labeling and Biological Evolution of New Thiopyrano[2,3-b]pyridine Derivatives as Potential Anticancer Agents

Synthesis, Labeling and Biological Evolution of New Thiopyrano[2,3-b]pyridine Derivatives as Potential Anticancer Agents

The new thiopyrano[2,3-b]pyridines 4–9 could be synthesized from the nicotinonitrile derivative 1. The cytotoxicity activity of the selected compounds 5, 6 and 8 was tested against MCF-7 and HCT-116 cell lines. The compound 5 (TP5) exhibited significant inhibitory activity and displayed the most pot...

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Bibliographic Details
Main Authors: Mamdouh Sofan, Wafaa Hamama, Ibrahim Ibrahim EL-Hawary, Ismail Taha Ibrahim, Hanafi Hassan Zoorob
Format: Article
Language:English
Published: Slovenian Chemical Society 2019-09-01
Series:Acta Chimica Slovenica
Subjects:
Nicotinonitrile
thiopyrano[2,3-b]pyridine
cytototoxic activity
ascites tumor
Online Access:https://journals.matheo.si/index.php/ACSi/article/view/4980

Internet

https://journals.matheo.si/index.php/ACSi/article/view/4980

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