The Proton Pump Inhibitor Omeprazole Does Not Promote <named-content content-type="genus-species">Clostridioides difficile</named-content> Colonization in a Murine Model

The Proton Pump Inhibitor Omeprazole Does Not Promote <named-content content-type="genus-species">Clostridioides difficile</named-content> Colonization in a Murine Model

ABSTRACT Proton pump inhibitor (PPI) use has been associated with microbiota alterations and susceptibility to Clostridioides difficile infections (CDIs) in humans. We assessed how PPI treatment alters the fecal microbiota and whether treatment promotes CDIs in a mouse model. Mice receiving a PPI tr...

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Bibliographic Details
Main Authors: Sarah Tomkovich, Nicholas A. Lesniak, Yuan Li, Lucas Bishop, Madison J. Fitzgerald, Patrick D. Schloss
Format: Article
Language:English
Published: American Society for Microbiology 2019-12-01
Series:mSphere
Subjects:
16S rRNA gene
Clostridioides difficile
Clostridium difficile
colonization resistance
infection
microbial ecology
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00693-19

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https://journals.asm.org/doi/10.1128/mSphere.00693-19

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