Ancient origins: complement in invertebrates
Proteins with obvious similarities to mammalian complement are widely distributed in the animal kingdom. In the vertebrate lineage, deuterostomes like sea urchins and tunicates express proteins that are homologues of C3, the central component of the vertebrate complement cascade. Their genomes also...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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University of Modena and Reggio Emilia
2005-08-01
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| Series: | Invertebrate Survival Journal |
| Subjects: | |
| Online Access: | https://isj02.unimore.it/index.php/ISJ/article/view/112 |
| _version_ | 1818765329953718272 |
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| author | S V Nair A Ramsden A Raftos |
| author_facet | S V Nair A Ramsden A Raftos |
| author_sort | S V Nair |
| collection | DOAJ |
| description | Proteins with obvious similarities to mammalian complement are widely distributed in the animal kingdom. In the vertebrate lineage, deuterostomes like sea urchins and tunicates express proteins that are homologues of C3, the central component of the vertebrate complement cascade. Their genomes also encode molecules resembling factor B from the “alternative” complement activation pathway; and tunicates have collagenous lectins of the type that can activate complement in the absence of antibodies. This suggests that the core components of the complement system evolved before antibodies, which first appear in jawed fish. |
| first_indexed | 2024-12-18T08:16:22Z |
| format | Article |
| id | doaj.art-768dc91717c44fbfa835b055f8907864 |
| institution | Directory Open Access Journal |
| issn | 1824-307X |
| language | English |
| last_indexed | 2024-12-18T08:16:22Z |
| publishDate | 2005-08-01 |
| publisher | University of Modena and Reggio Emilia |
| record_format | Article |
| series | Invertebrate Survival Journal |
| spelling | doaj.art-768dc91717c44fbfa835b055f89078642022-12-21T21:14:49ZengUniversity of Modena and Reggio EmiliaInvertebrate Survival Journal1824-307X2005-08-0122Ancient origins: complement in invertebratesS V Nair0A Ramsden1A Raftos2Department of Biological Sciences, Macquarie University, North Ryde, NSW 2109, AustraliaDepartment of Biological Sciences, Macquarie University, North Ryde, NSW 2109, AustraliaDepartment of Biological Sciences, Macquarie University, North Ryde, NSW 2109, AustraliaProteins with obvious similarities to mammalian complement are widely distributed in the animal kingdom. In the vertebrate lineage, deuterostomes like sea urchins and tunicates express proteins that are homologues of C3, the central component of the vertebrate complement cascade. Their genomes also encode molecules resembling factor B from the “alternative” complement activation pathway; and tunicates have collagenous lectins of the type that can activate complement in the absence of antibodies. This suggests that the core components of the complement system evolved before antibodies, which first appear in jawed fish.https://isj02.unimore.it/index.php/ISJ/article/view/112C3collectinscomplementinvertebrate immune systemsTEP proteins |
| spellingShingle | S V Nair A Ramsden A Raftos Ancient origins: complement in invertebrates Invertebrate Survival Journal C3 collectins complement invertebrate immune systems TEP proteins |
| title | Ancient origins: complement in invertebrates |
| title_full | Ancient origins: complement in invertebrates |
| title_fullStr | Ancient origins: complement in invertebrates |
| title_full_unstemmed | Ancient origins: complement in invertebrates |
| title_short | Ancient origins: complement in invertebrates |
| title_sort | ancient origins complement in invertebrates |
| topic | C3 collectins complement invertebrate immune systems TEP proteins |
| url | https://isj02.unimore.it/index.php/ISJ/article/view/112 |
| work_keys_str_mv | AT svnair ancientoriginscomplementininvertebrates AT aramsden ancientoriginscomplementininvertebrates AT araftos ancientoriginscomplementininvertebrates |