Enhanced Anti-Obesity Activities of Red Mold Dioscorea When Fermented Using Deep Ocean Water as the Culture Water
Deep ocean water (DOW) has, in previous studies, been found to be a novel anti-obesity drink and useful in raising Monascus-produced monascin and ankaflavin levels. This may resolve the limited anti-obesity ability of red mold dioscorea (RMD) known as the Monascus purpureus-fermented Disocorea batat...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2013-10-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/11/10/3902 |
| _version_ | 1798025839820931072 |
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| author | Tzu-Ming Pan Chun-Lin Lee Jyh-Jye Wang Tsung-Yu Tsai Bai-Luh Wei Yi-Hsin Kung Tzu-Ying Lung Li-Chun Wang |
| author_facet | Tzu-Ming Pan Chun-Lin Lee Jyh-Jye Wang Tsung-Yu Tsai Bai-Luh Wei Yi-Hsin Kung Tzu-Ying Lung Li-Chun Wang |
| author_sort | Tzu-Ming Pan |
| collection | DOAJ |
| description | Deep ocean water (DOW) has, in previous studies, been found to be a novel anti-obesity drink and useful in raising Monascus-produced monascin and ankaflavin levels. This may resolve the limited anti-obesity ability of red mold dioscorea (RMD) known as the Monascus purpureus-fermented Disocorea batatas. This study aims to compare the anti-obesity effect of DOW-cultured RMD (DOW-RMD) and ultra-pure water-cultured RMD (UPW-RMD) in rats fed on a high fat diet. Moreover, the effect of ions composition of DOW and DOW-influenced functional metabolites change of RMD on the differentiation and lipogenesis regulation were investigated using 3T3-L1 pre-adipocytes. In the animal test, compared to UPW-RMD, DOW-RMD possessed better ability to inhibit increases in weight gain, and better feed efficiency, body-fat pad and cross-sectional area of adipocytes. In the cell test, the anti-obesity abilities of DOW-RMD in inhibiting PPARγ and C/EBPα expression in differentiation and lipoprotein lipase activity in lipogenesis were contributed to by the DOW-increased monascin and ankaflavin levels and the ions of DOW, respectively. |
| first_indexed | 2024-04-11T18:26:29Z |
| format | Article |
| id | doaj.art-768df3c8c1c44d098372f9d5f9a38991 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T18:26:29Z |
| publishDate | 2013-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-768df3c8c1c44d098372f9d5f9a389912022-12-22T04:09:37ZengMDPI AGMarine Drugs1660-33972013-10-0111103902392510.3390/md11103902Enhanced Anti-Obesity Activities of Red Mold Dioscorea When Fermented Using Deep Ocean Water as the Culture WaterTzu-Ming PanChun-Lin LeeJyh-Jye WangTsung-Yu TsaiBai-Luh WeiYi-Hsin KungTzu-Ying LungLi-Chun WangDeep ocean water (DOW) has, in previous studies, been found to be a novel anti-obesity drink and useful in raising Monascus-produced monascin and ankaflavin levels. This may resolve the limited anti-obesity ability of red mold dioscorea (RMD) known as the Monascus purpureus-fermented Disocorea batatas. This study aims to compare the anti-obesity effect of DOW-cultured RMD (DOW-RMD) and ultra-pure water-cultured RMD (UPW-RMD) in rats fed on a high fat diet. Moreover, the effect of ions composition of DOW and DOW-influenced functional metabolites change of RMD on the differentiation and lipogenesis regulation were investigated using 3T3-L1 pre-adipocytes. In the animal test, compared to UPW-RMD, DOW-RMD possessed better ability to inhibit increases in weight gain, and better feed efficiency, body-fat pad and cross-sectional area of adipocytes. In the cell test, the anti-obesity abilities of DOW-RMD in inhibiting PPARγ and C/EBPα expression in differentiation and lipoprotein lipase activity in lipogenesis were contributed to by the DOW-increased monascin and ankaflavin levels and the ions of DOW, respectively.http://www.mdpi.com/1660-3397/11/10/3902deep ocean waterobesityMonascusmonascinankaflavin |
| spellingShingle | Tzu-Ming Pan Chun-Lin Lee Jyh-Jye Wang Tsung-Yu Tsai Bai-Luh Wei Yi-Hsin Kung Tzu-Ying Lung Li-Chun Wang Enhanced Anti-Obesity Activities of Red Mold Dioscorea When Fermented Using Deep Ocean Water as the Culture Water Marine Drugs deep ocean water obesity Monascus monascin ankaflavin |
| title | Enhanced Anti-Obesity Activities of Red Mold Dioscorea When Fermented Using Deep Ocean Water as the Culture Water |
| title_full | Enhanced Anti-Obesity Activities of Red Mold Dioscorea When Fermented Using Deep Ocean Water as the Culture Water |
| title_fullStr | Enhanced Anti-Obesity Activities of Red Mold Dioscorea When Fermented Using Deep Ocean Water as the Culture Water |
| title_full_unstemmed | Enhanced Anti-Obesity Activities of Red Mold Dioscorea When Fermented Using Deep Ocean Water as the Culture Water |
| title_short | Enhanced Anti-Obesity Activities of Red Mold Dioscorea When Fermented Using Deep Ocean Water as the Culture Water |
| title_sort | enhanced anti obesity activities of red mold dioscorea when fermented using deep ocean water as the culture water |
| topic | deep ocean water obesity Monascus monascin ankaflavin |
| url | http://www.mdpi.com/1660-3397/11/10/3902 |
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