The Role of MicroRNAs in Uterine Leiomyosarcoma Diagnosis and Treatment
Uterine sarcomas are rare gynecological tumors arising from the myometrium or the connective tissue of the endometrium with a relatively poor prognosis. MicroRNAs (miRNAs) represent small, single-stranded, non-coding RNA molecules that can function as oncogenes or tumor suppressors under certain con...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/9/2420 |
| _version_ | 1797602916768415744 |
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| author | Iason Psilopatis Kleio Vrettou Stefania Kokkali Stamatios Theocharis |
| author_facet | Iason Psilopatis Kleio Vrettou Stefania Kokkali Stamatios Theocharis |
| author_sort | Iason Psilopatis |
| collection | DOAJ |
| description | Uterine sarcomas are rare gynecological tumors arising from the myometrium or the connective tissue of the endometrium with a relatively poor prognosis. MicroRNAs (miRNAs) represent small, single-stranded, non-coding RNA molecules that can function as oncogenes or tumor suppressors under certain conditions. The current review aims at studying the role of miRNAs in uterine sarcoma diagnosis and treatment. In order to identify relevant studies, a literature review was conducted using the MEDLINE and LIVIVO databases. The search terms “microRNA” and “uterine sarcoma” were employed, and we were able to identify 24 studies published between 2008 and 2022. The current manuscript represents the first comprehensive review of the literature focusing on the particular role of miRNAs as biomarkers for uterine sarcomas. miRNAs were found to exhibit differential expression in uterine sarcoma cell lines and interact with certain genes correlating with tumorigenesis and cancer progression, whereas selected miRNA isoforms seem to be either over- or under-expressed in uterine sarcoma samples compared to normal uteri or benign tumors. Furthermore, miRNA levels correlate with various clinical prognostic parameters in uterine sarcoma patients, whereas each uterine sarcoma subtype is characterized by a unique miRNA profile. In summary, miRNAs seemingly represent novel trustworthy biomarkers for the diagnosis and treatment of uterine sarcoma. |
| first_indexed | 2024-03-11T04:23:17Z |
| format | Article |
| id | doaj.art-768e23940ec14a579fc754ed06ef5697 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T04:23:17Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-768e23940ec14a579fc754ed06ef56972023-11-17T22:39:29ZengMDPI AGCancers2072-66942023-04-01159242010.3390/cancers15092420The Role of MicroRNAs in Uterine Leiomyosarcoma Diagnosis and TreatmentIason Psilopatis0Kleio Vrettou1Stefania Kokkali2Stamatios Theocharis3First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Bld 10, Goudi, 11527 Athens, GreeceFirst Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Bld 10, Goudi, 11527 Athens, GreeceFirst Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Bld 10, Goudi, 11527 Athens, GreeceFirst Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Bld 10, Goudi, 11527 Athens, GreeceUterine sarcomas are rare gynecological tumors arising from the myometrium or the connective tissue of the endometrium with a relatively poor prognosis. MicroRNAs (miRNAs) represent small, single-stranded, non-coding RNA molecules that can function as oncogenes or tumor suppressors under certain conditions. The current review aims at studying the role of miRNAs in uterine sarcoma diagnosis and treatment. In order to identify relevant studies, a literature review was conducted using the MEDLINE and LIVIVO databases. The search terms “microRNA” and “uterine sarcoma” were employed, and we were able to identify 24 studies published between 2008 and 2022. The current manuscript represents the first comprehensive review of the literature focusing on the particular role of miRNAs as biomarkers for uterine sarcomas. miRNAs were found to exhibit differential expression in uterine sarcoma cell lines and interact with certain genes correlating with tumorigenesis and cancer progression, whereas selected miRNA isoforms seem to be either over- or under-expressed in uterine sarcoma samples compared to normal uteri or benign tumors. Furthermore, miRNA levels correlate with various clinical prognostic parameters in uterine sarcoma patients, whereas each uterine sarcoma subtype is characterized by a unique miRNA profile. In summary, miRNAs seemingly represent novel trustworthy biomarkers for the diagnosis and treatment of uterine sarcoma.https://www.mdpi.com/2072-6694/15/9/2420microRNAuterinesarcomabiomarkerdiagnosistreatment |
| spellingShingle | Iason Psilopatis Kleio Vrettou Stefania Kokkali Stamatios Theocharis The Role of MicroRNAs in Uterine Leiomyosarcoma Diagnosis and Treatment Cancers microRNA uterine sarcoma biomarker diagnosis treatment |
| title | The Role of MicroRNAs in Uterine Leiomyosarcoma Diagnosis and Treatment |
| title_full | The Role of MicroRNAs in Uterine Leiomyosarcoma Diagnosis and Treatment |
| title_fullStr | The Role of MicroRNAs in Uterine Leiomyosarcoma Diagnosis and Treatment |
| title_full_unstemmed | The Role of MicroRNAs in Uterine Leiomyosarcoma Diagnosis and Treatment |
| title_short | The Role of MicroRNAs in Uterine Leiomyosarcoma Diagnosis and Treatment |
| title_sort | role of micrornas in uterine leiomyosarcoma diagnosis and treatment |
| topic | microRNA uterine sarcoma biomarker diagnosis treatment |
| url | https://www.mdpi.com/2072-6694/15/9/2420 |
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