An updated review of the immunological mechanisms of keloid scars
Keloid is a type of disfiguring pathological scarring unique to human skin. The disorder is characterized by excessive collagen deposition. Immune cell infiltration is a hallmark of both normal and pathological tissue repair. However, the immunopathological mechanisms of keloid remain unclear. Recen...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1117630/full |
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| author | Chih-Chun Lee Chia-Hsuan Tsai Chia-Hsuan Tsai Chih-Hao Chen Chih-Hao Chen Yuan-Chieh Yeh Yuan-Chieh Yeh Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen |
| author_facet | Chih-Chun Lee Chia-Hsuan Tsai Chia-Hsuan Tsai Chih-Hao Chen Chih-Hao Chen Yuan-Chieh Yeh Yuan-Chieh Yeh Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen |
| author_sort | Chih-Chun Lee |
| collection | DOAJ |
| description | Keloid is a type of disfiguring pathological scarring unique to human skin. The disorder is characterized by excessive collagen deposition. Immune cell infiltration is a hallmark of both normal and pathological tissue repair. However, the immunopathological mechanisms of keloid remain unclear. Recent studies have uncovered the pivotal role of both innate and adaptive immunity in modulating the aberrant behavior of keloid fibroblasts. Several novel therapeutics attempting to restore regulation of the immune microenvironment have shown variable efficacy. We review the current understanding of keloid immunopathogenesis and highlight the potential roles of immune pathway-specific therapeutics. |
| first_indexed | 2024-04-09T22:21:44Z |
| format | Article |
| id | doaj.art-768e5f706e944b8f808bf0295f7b34a7 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-09T22:21:44Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-768e5f706e944b8f808bf0295f7b34a72023-03-22T14:32:14ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-03-011410.3389/fimmu.2023.11176301117630An updated review of the immunological mechanisms of keloid scarsChih-Chun Lee0Chia-Hsuan Tsai1Chia-Hsuan Tsai2Chih-Hao Chen3Chih-Hao Chen4Yuan-Chieh Yeh5Yuan-Chieh Yeh6Wen-Hung Chung7Wen-Hung Chung8Wen-Hung Chung9Wen-Hung Chung10Wen-Hung Chung11Wen-Hung Chung12Wen-Hung Chung13Wen-Hung Chung14Wen-Hung Chung15Wen-Hung Chung16Wen-Hung Chung17Wen-Hung Chung18Chun-Bing Chen19Chun-Bing Chen20Chun-Bing Chen21Chun-Bing Chen22Chun-Bing Chen23Chun-Bing Chen24Chun-Bing Chen25Chun-Bing Chen26Chun-Bing Chen27Chun-Bing Chen28Chun-Bing Chen29Chun-Bing Chen30Chun-Bing Chen311 Department of Medical Education, Chang Gung Memorial Hospital, Keelung, TaiwanDepartment of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Keelung, TaiwanCollege of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Keelung, TaiwanCollege of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Keelung, TaiwanProgram in Molecular Medicine, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei, TaiwanCollege of Medicine, Chang Gung University, Taoyuan, TaiwanDrug Hypersensitivity Clinical and Research Center, Department of Dermatology, Chang Gung Memorial Hospital, Linkou, TaiwanDrug Hypersensitivity Clinical and Research Center, Department of Dermatology, Chang Gung Memorial Hospital, Taipei, TaiwanDrug Hypersensitivity Clinical and Research Center, Department of Dermatology, Chang Gung Memorial Hospital, Keelung, TaiwanCancer Vaccine and Immune Cell Therapy Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan0Chang Gung Immunology Consortium, Chang Gung Memorial Hospital and Chang Gung University, Linkou, Taiwan1Department of Dermatology, Xiamen Chang Gung Hospital, Xiamen, China2Xiamen Chang Gung Allergology Consortium, Xiamen Chang Gung Hospital, Xiamen, China3Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan4Immune-Oncology Center of Excellence, Chang Gung Memorial Hospital, Linkou, Taiwan5Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan6Genomic Medicine Core Laboratory, Chang Gung Memorial Hospital, Linkou, TaiwanCollege of Medicine, Chang Gung University, Taoyuan, TaiwanDrug Hypersensitivity Clinical and Research Center, Department of Dermatology, Chang Gung Memorial Hospital, Linkou, TaiwanDrug Hypersensitivity Clinical and Research Center, Department of Dermatology, Chang Gung Memorial Hospital, Taipei, TaiwanDrug Hypersensitivity Clinical and Research Center, Department of Dermatology, Chang Gung Memorial Hospital, Keelung, TaiwanCancer Vaccine and Immune Cell Therapy Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan0Chang Gung Immunology Consortium, Chang Gung Memorial Hospital and Chang Gung University, Linkou, Taiwan1Department of Dermatology, Xiamen Chang Gung Hospital, Xiamen, China2Xiamen Chang Gung Allergology Consortium, Xiamen Chang Gung Hospital, Xiamen, China3Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan4Immune-Oncology Center of Excellence, Chang Gung Memorial Hospital, Linkou, Taiwan5Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan6Genomic Medicine Core Laboratory, Chang Gung Memorial Hospital, Linkou, Taiwan7School of Medicine, National Tsing Hua University, Hsinchu, TaiwanKeloid is a type of disfiguring pathological scarring unique to human skin. The disorder is characterized by excessive collagen deposition. Immune cell infiltration is a hallmark of both normal and pathological tissue repair. However, the immunopathological mechanisms of keloid remain unclear. Recent studies have uncovered the pivotal role of both innate and adaptive immunity in modulating the aberrant behavior of keloid fibroblasts. Several novel therapeutics attempting to restore regulation of the immune microenvironment have shown variable efficacy. We review the current understanding of keloid immunopathogenesis and highlight the potential roles of immune pathway-specific therapeutics.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1117630/fullkeloidscarimmunitymacrophagesT lymphocytescytokines |
| spellingShingle | Chih-Chun Lee Chia-Hsuan Tsai Chia-Hsuan Tsai Chih-Hao Chen Chih-Hao Chen Yuan-Chieh Yeh Yuan-Chieh Yeh Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Wen-Hung Chung Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen Chun-Bing Chen An updated review of the immunological mechanisms of keloid scars Frontiers in Immunology keloid scar immunity macrophages T lymphocytes cytokines |
| title | An updated review of the immunological mechanisms of keloid scars |
| title_full | An updated review of the immunological mechanisms of keloid scars |
| title_fullStr | An updated review of the immunological mechanisms of keloid scars |
| title_full_unstemmed | An updated review of the immunological mechanisms of keloid scars |
| title_short | An updated review of the immunological mechanisms of keloid scars |
| title_sort | updated review of the immunological mechanisms of keloid scars |
| topic | keloid scar immunity macrophages T lymphocytes cytokines |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1117630/full |
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