Circulating tumor cell-derived preclinical models: current status and future perspectives
Abstract Despite the advancements made in the diagnosis and treatment of cancer, the stages associated with metastasis remain largely incurable and represent the primary cause of cancer-related deaths. The dissemination of cancer is facilitated by circulating tumor cells (CTCs), which originate from...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-08-01
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| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-023-06059-6 |
| _version_ | 1797740727498702848 |
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| author | Zuzana Kahounová Markéta Pícková Stanislav Drápela Jan Bouchal Eva Szczyrbová Jiří Navrátil Karel Souček |
| author_facet | Zuzana Kahounová Markéta Pícková Stanislav Drápela Jan Bouchal Eva Szczyrbová Jiří Navrátil Karel Souček |
| author_sort | Zuzana Kahounová |
| collection | DOAJ |
| description | Abstract Despite the advancements made in the diagnosis and treatment of cancer, the stages associated with metastasis remain largely incurable and represent the primary cause of cancer-related deaths. The dissemination of cancer is facilitated by circulating tumor cells (CTCs), which originate from the primary tumor or metastatic sites and enter the bloodstream, subsequently spreading to distant parts of the body. CTCs have garnered significant attention in research due to their accessibility in peripheral blood, despite their low abundance. They are being extensively studied to gain a deeper understanding of the mechanisms underlying cancer dissemination and to identify effective therapeutic strategies for advanced stages of the disease. Therefore, substantial efforts have been directed towards establishing and characterizing relevant experimental models derived from CTCs, aiming to provide relevant tools for research. In this review, we provide an overview of recent progress in the establishment of preclinical CTC-derived models, such as CTC-derived xenografts (CDX) and cell cultures, which show promise for the study of CTCs. We discuss the advantages and limitations of these models and conclude by summarizing the potential future use of CTCs and CTC-derived models in cancer treatment decisions and their utility as precision medicine tools. |
| first_indexed | 2024-03-12T14:16:34Z |
| format | Article |
| id | doaj.art-76914d3e92714ee7a0aaef1af6d4853f |
| institution | Directory Open Access Journal |
| issn | 2041-4889 |
| language | English |
| last_indexed | 2024-03-12T14:16:34Z |
| publishDate | 2023-08-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death and Disease |
| spelling | doaj.art-76914d3e92714ee7a0aaef1af6d4853f2023-08-20T11:22:22ZengNature Publishing GroupCell Death and Disease2041-48892023-08-0114811210.1038/s41419-023-06059-6Circulating tumor cell-derived preclinical models: current status and future perspectivesZuzana Kahounová0Markéta Pícková1Stanislav Drápela2Jan Bouchal3Eva Szczyrbová4Jiří Navrátil5Karel Souček6Department of Cytokinetics, Institute of Biophysics of the Czech Academy of SciencesDepartment of Cytokinetics, Institute of Biophysics of the Czech Academy of SciencesDepartment of Cytokinetics, Institute of Biophysics of the Czech Academy of SciencesDepartment of Clinical and Molecular Pathology, Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University and University HospitalDepartment of Clinical and Molecular Pathology, Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University and University HospitalDepartment of Comprehensive Cancer Care, Masaryk Memorial Cancer InstituteDepartment of Cytokinetics, Institute of Biophysics of the Czech Academy of SciencesAbstract Despite the advancements made in the diagnosis and treatment of cancer, the stages associated with metastasis remain largely incurable and represent the primary cause of cancer-related deaths. The dissemination of cancer is facilitated by circulating tumor cells (CTCs), which originate from the primary tumor or metastatic sites and enter the bloodstream, subsequently spreading to distant parts of the body. CTCs have garnered significant attention in research due to their accessibility in peripheral blood, despite their low abundance. They are being extensively studied to gain a deeper understanding of the mechanisms underlying cancer dissemination and to identify effective therapeutic strategies for advanced stages of the disease. Therefore, substantial efforts have been directed towards establishing and characterizing relevant experimental models derived from CTCs, aiming to provide relevant tools for research. In this review, we provide an overview of recent progress in the establishment of preclinical CTC-derived models, such as CTC-derived xenografts (CDX) and cell cultures, which show promise for the study of CTCs. We discuss the advantages and limitations of these models and conclude by summarizing the potential future use of CTCs and CTC-derived models in cancer treatment decisions and their utility as precision medicine tools.https://doi.org/10.1038/s41419-023-06059-6 |
| spellingShingle | Zuzana Kahounová Markéta Pícková Stanislav Drápela Jan Bouchal Eva Szczyrbová Jiří Navrátil Karel Souček Circulating tumor cell-derived preclinical models: current status and future perspectives Cell Death and Disease |
| title | Circulating tumor cell-derived preclinical models: current status and future perspectives |
| title_full | Circulating tumor cell-derived preclinical models: current status and future perspectives |
| title_fullStr | Circulating tumor cell-derived preclinical models: current status and future perspectives |
| title_full_unstemmed | Circulating tumor cell-derived preclinical models: current status and future perspectives |
| title_short | Circulating tumor cell-derived preclinical models: current status and future perspectives |
| title_sort | circulating tumor cell derived preclinical models current status and future perspectives |
| url | https://doi.org/10.1038/s41419-023-06059-6 |
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