Proteolytic Regulation of the Lectin-Like Oxidized Lipoprotein Receptor LOX-1

Proteolytic Regulation of the Lectin-Like Oxidized Lipoprotein Receptor LOX-1

The lectin-like oxidized-LDL (oxLDL) receptor LOX-1, which is broadly expressed in vascular cells, represents a key mediator of endothelial activation and dysfunction in atherosclerotic plaque development. Being a member of the C-type lectin receptor family, LOX-1 can bind different ligands, with ox...

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Bibliographic Details
Main Authors: Torben Mentrup, Florencia Cabrera-Cabrera, Bernd Schröder
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
LOX-1
atherosclerosis
protease
intramembrane protease
ectodomain shedding
signal transduction
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2020.594441/full

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