Comparing the hippocampal volumetric atrophy between demented and nondemented individuals with Parkinson's disease: A systematic review and meta‐analysis
Abstract Background Parkinson's disease (PD) is one of the most common neurodegenerative conditions in the world and, when combined with dementia, can lead to immense cerebral volume loss. Of significant importance among all cerebral regions, is the hippocampus. This region plays a pivotal role...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-09-01
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| Series: | Health Science Reports |
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| Online Access: | https://doi.org/10.1002/hsr2.1514 |
| _version_ | 1797672493807304704 |
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| author | Mohammad Yazdan Panah Yousef Mokary Sangam Shah Sangharsha Thapa Swati Chand Vahid Shaygannejad Omid Mirmosayyeb |
| author_facet | Mohammad Yazdan Panah Yousef Mokary Sangam Shah Sangharsha Thapa Swati Chand Vahid Shaygannejad Omid Mirmosayyeb |
| author_sort | Mohammad Yazdan Panah |
| collection | DOAJ |
| description | Abstract Background Parkinson's disease (PD) is one of the most common neurodegenerative conditions in the world and, when combined with dementia, can lead to immense cerebral volume loss. Of significant importance among all cerebral regions, is the hippocampus. This region plays a pivotal role in memory, and understanding its pathological alterations can answer vital questions regarding dementia. As such, we designed this study to compare the hippocampal volumes of PD patients with dementia (PDD) versus PD without dementia. Methods PubMed, Web of Science, Scopus, and Embase were searched for relevant studies. We also searched the references sections of all included studies. The original search began in March 2022 and was extended to the end of July 2022. All related data were extracted from the studies. If the studies were conducted on patients from comparable patient groups, the most recent study with the most extensive data set would be included. Results A statistically significant difference was observed comparing the raw hippocampal volumes in participants with PDD and PD (p value = 0.01). In a comparison of normalized hippocampal volume between PDD and PD, there was a statistically significant difference (p value < 0.01), as well. Conclusion Although further research is required to illuminate the temporal relation between the onset of dementia and hippocampal atrophy in demented PD individuals, the present study highlights the importance of utilizing volumetric studies on memory‐related cerebral regions to diagnose the initiation of dementia in the early stages. |
| first_indexed | 2024-03-11T21:30:52Z |
| format | Article |
| id | doaj.art-769942da0205470fae9ae7f9cca31b5c |
| institution | Directory Open Access Journal |
| issn | 2398-8835 |
| language | English |
| last_indexed | 2024-03-11T21:30:52Z |
| publishDate | 2023-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj.art-769942da0205470fae9ae7f9cca31b5c2023-09-27T09:16:35ZengWileyHealth Science Reports2398-88352023-09-0169n/an/a10.1002/hsr2.1514Comparing the hippocampal volumetric atrophy between demented and nondemented individuals with Parkinson's disease: A systematic review and meta‐analysisMohammad Yazdan Panah0Yousef Mokary1Sangam Shah2Sangharsha Thapa3Swati Chand4Vahid Shaygannejad5Omid Mirmosayyeb6Isfahan Neurosciences Research Center Isfahan University of Medical Sciences Isfahan IranIsfahan Neurosciences Research Center Isfahan University of Medical Sciences Isfahan IranInstitute of Medicine Tribhuvan University Maharajgunj NepalKathmandu University School of Medical Sciences Dhulikhel NepalRochester General Hospital Rochester New York USAIsfahan Neurosciences Research Center Isfahan University of Medical Sciences Isfahan IranIsfahan Neurosciences Research Center Isfahan University of Medical Sciences Isfahan IranAbstract Background Parkinson's disease (PD) is one of the most common neurodegenerative conditions in the world and, when combined with dementia, can lead to immense cerebral volume loss. Of significant importance among all cerebral regions, is the hippocampus. This region plays a pivotal role in memory, and understanding its pathological alterations can answer vital questions regarding dementia. As such, we designed this study to compare the hippocampal volumes of PD patients with dementia (PDD) versus PD without dementia. Methods PubMed, Web of Science, Scopus, and Embase were searched for relevant studies. We also searched the references sections of all included studies. The original search began in March 2022 and was extended to the end of July 2022. All related data were extracted from the studies. If the studies were conducted on patients from comparable patient groups, the most recent study with the most extensive data set would be included. Results A statistically significant difference was observed comparing the raw hippocampal volumes in participants with PDD and PD (p value = 0.01). In a comparison of normalized hippocampal volume between PDD and PD, there was a statistically significant difference (p value < 0.01), as well. Conclusion Although further research is required to illuminate the temporal relation between the onset of dementia and hippocampal atrophy in demented PD individuals, the present study highlights the importance of utilizing volumetric studies on memory‐related cerebral regions to diagnose the initiation of dementia in the early stages.https://doi.org/10.1002/hsr2.1514dementiahippocampal atrophyParkinson's diseasevolumetry |
| spellingShingle | Mohammad Yazdan Panah Yousef Mokary Sangam Shah Sangharsha Thapa Swati Chand Vahid Shaygannejad Omid Mirmosayyeb Comparing the hippocampal volumetric atrophy between demented and nondemented individuals with Parkinson's disease: A systematic review and meta‐analysis Health Science Reports dementia hippocampal atrophy Parkinson's disease volumetry |
| title | Comparing the hippocampal volumetric atrophy between demented and nondemented individuals with Parkinson's disease: A systematic review and meta‐analysis |
| title_full | Comparing the hippocampal volumetric atrophy between demented and nondemented individuals with Parkinson's disease: A systematic review and meta‐analysis |
| title_fullStr | Comparing the hippocampal volumetric atrophy between demented and nondemented individuals with Parkinson's disease: A systematic review and meta‐analysis |
| title_full_unstemmed | Comparing the hippocampal volumetric atrophy between demented and nondemented individuals with Parkinson's disease: A systematic review and meta‐analysis |
| title_short | Comparing the hippocampal volumetric atrophy between demented and nondemented individuals with Parkinson's disease: A systematic review and meta‐analysis |
| title_sort | comparing the hippocampal volumetric atrophy between demented and nondemented individuals with parkinson s disease a systematic review and meta analysis |
| topic | dementia hippocampal atrophy Parkinson's disease volumetry |
| url | https://doi.org/10.1002/hsr2.1514 |
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