The relationship of early recurrence of atrial fibrillation and the 3-month integrity of the ablation lesion set
Abstract Early recurrence of atrial fibrillation (ERAF) after catheter-ablation (CA) can be a transient phenomenon due to inflammation, or a harbinger of late AF recurrence due to CA lesion (re)conduction. We studied the relationship between ERAF and the 3-month CA lesions integrity. Forty one conse...
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Nature Portfolio
2018-06-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-018-28072-y |
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author | Nebojša Mujović Milan Marinković Nebojša Marković Vera Vučićević Gregory Y. H. Lip T. Jared Bunch Tatjana S. Potpara |
author_facet | Nebojša Mujović Milan Marinković Nebojša Marković Vera Vučićević Gregory Y. H. Lip T. Jared Bunch Tatjana S. Potpara |
author_sort | Nebojša Mujović |
collection | DOAJ |
description | Abstract Early recurrence of atrial fibrillation (ERAF) after catheter-ablation (CA) can be a transient phenomenon due to inflammation, or a harbinger of late AF recurrence due to CA lesion (re)conduction. We studied the relationship between ERAF and the 3-month CA lesions integrity. Forty one consecutive AF patients who underwent a pulmonary vein isolation (PVI), roof line (RL) and mitral isthmus line (MIL) CA were enrolled. At 3 months all patients underwent invasive assessment of the lesion set integrity irrespective of ERAF. The PVI, RL and MIL ablation was successful in 100.0%, 95.1% and 82.9% patients, respectively. At the 3-month remapping, a gap in PVI-lesion(s), RL or MIL was identified in 61.0%, 31.7% and 36.6% patients, respectively. Patients with (n = 17, 41.5%) compared to those without ERAF (n = 24) had a significantly higher rate of any PV-reconnection (88.2% vs. 41.7%), the right PV(s)-reconnection (82.5% vs. 29.2%) and the RL gap (52.9% vs. 16.7%), as well as a higher number of reconnected right PVI-segments, all p < 0.05. On multivariate analysis, only the number of reconnected right PVI-segments was associated with ERAF (OR 4.26, p = 0.004). The ERAF following PVI + RL + MIL ablation was significantly related to 3-month PV-reconnections and the presence of RL gaps. |
first_indexed | 2024-12-23T03:32:34Z |
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id | doaj.art-7699f128f6794494b2f002fb39045535 |
institution | Directory Open Access Journal |
issn | 2045-2322 |
language | English |
last_indexed | 2024-12-23T03:32:34Z |
publishDate | 2018-06-01 |
publisher | Nature Portfolio |
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series | Scientific Reports |
spelling | doaj.art-7699f128f6794494b2f002fb390455352022-12-21T18:01:37ZengNature PortfolioScientific Reports2045-23222018-06-018111010.1038/s41598-018-28072-yThe relationship of early recurrence of atrial fibrillation and the 3-month integrity of the ablation lesion setNebojša Mujović0Milan Marinković1Nebojša Marković2Vera Vučićević3Gregory Y. H. Lip4T. Jared Bunch5Tatjana S. Potpara6Cardiology Clinic, Clinical Center of SerbiaCardiology Clinic, Clinical Center of SerbiaCardiology Clinic, Clinical Center of SerbiaCenter for Anesthesiology and Reanimatology, Clinical Center of SerbiaCardiology Department, City HospitalIntermountain Medical Center Heart Institute, Intermountain Medical CenterCardiology Clinic, Clinical Center of SerbiaAbstract Early recurrence of atrial fibrillation (ERAF) after catheter-ablation (CA) can be a transient phenomenon due to inflammation, or a harbinger of late AF recurrence due to CA lesion (re)conduction. We studied the relationship between ERAF and the 3-month CA lesions integrity. Forty one consecutive AF patients who underwent a pulmonary vein isolation (PVI), roof line (RL) and mitral isthmus line (MIL) CA were enrolled. At 3 months all patients underwent invasive assessment of the lesion set integrity irrespective of ERAF. The PVI, RL and MIL ablation was successful in 100.0%, 95.1% and 82.9% patients, respectively. At the 3-month remapping, a gap in PVI-lesion(s), RL or MIL was identified in 61.0%, 31.7% and 36.6% patients, respectively. Patients with (n = 17, 41.5%) compared to those without ERAF (n = 24) had a significantly higher rate of any PV-reconnection (88.2% vs. 41.7%), the right PV(s)-reconnection (82.5% vs. 29.2%) and the RL gap (52.9% vs. 16.7%), as well as a higher number of reconnected right PVI-segments, all p < 0.05. On multivariate analysis, only the number of reconnected right PVI-segments was associated with ERAF (OR 4.26, p = 0.004). The ERAF following PVI + RL + MIL ablation was significantly related to 3-month PV-reconnections and the presence of RL gaps.https://doi.org/10.1038/s41598-018-28072-y |
spellingShingle | Nebojša Mujović Milan Marinković Nebojša Marković Vera Vučićević Gregory Y. H. Lip T. Jared Bunch Tatjana S. Potpara The relationship of early recurrence of atrial fibrillation and the 3-month integrity of the ablation lesion set Scientific Reports |
title | The relationship of early recurrence of atrial fibrillation and the 3-month integrity of the ablation lesion set |
title_full | The relationship of early recurrence of atrial fibrillation and the 3-month integrity of the ablation lesion set |
title_fullStr | The relationship of early recurrence of atrial fibrillation and the 3-month integrity of the ablation lesion set |
title_full_unstemmed | The relationship of early recurrence of atrial fibrillation and the 3-month integrity of the ablation lesion set |
title_short | The relationship of early recurrence of atrial fibrillation and the 3-month integrity of the ablation lesion set |
title_sort | relationship of early recurrence of atrial fibrillation and the 3 month integrity of the ablation lesion set |
url | https://doi.org/10.1038/s41598-018-28072-y |
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