The relationship of early recurrence of atrial fibrillation and the 3-month integrity of the ablation lesion set

Abstract Early recurrence of atrial fibrillation (ERAF) after catheter-ablation (CA) can be a transient phenomenon due to inflammation, or a harbinger of late AF recurrence due to CA lesion (re)conduction. We studied the relationship between ERAF and the 3-month CA lesions integrity. Forty one conse...

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Main Authors: Nebojša Mujović, Milan Marinković, Nebojša Marković, Vera Vučićević, Gregory Y. H. Lip, T. Jared Bunch, Tatjana S. Potpara
Format: Article
Language:English
Published: Nature Portfolio 2018-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-28072-y
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author Nebojša Mujović
Milan Marinković
Nebojša Marković
Vera Vučićević
Gregory Y. H. Lip
T. Jared Bunch
Tatjana S. Potpara
author_facet Nebojša Mujović
Milan Marinković
Nebojša Marković
Vera Vučićević
Gregory Y. H. Lip
T. Jared Bunch
Tatjana S. Potpara
author_sort Nebojša Mujović
collection DOAJ
description Abstract Early recurrence of atrial fibrillation (ERAF) after catheter-ablation (CA) can be a transient phenomenon due to inflammation, or a harbinger of late AF recurrence due to CA lesion (re)conduction. We studied the relationship between ERAF and the 3-month CA lesions integrity. Forty one consecutive AF patients who underwent a pulmonary vein isolation (PVI), roof line (RL) and mitral isthmus line (MIL) CA were enrolled. At 3 months all patients underwent invasive assessment of the lesion set integrity irrespective of ERAF. The PVI, RL and MIL ablation was successful in 100.0%, 95.1% and 82.9% patients, respectively. At the 3-month remapping, a gap in PVI-lesion(s), RL or MIL was identified in 61.0%, 31.7% and 36.6% patients, respectively. Patients with (n = 17, 41.5%) compared to those without ERAF (n = 24) had a significantly higher rate of any PV-reconnection (88.2% vs. 41.7%), the right PV(s)-reconnection (82.5% vs. 29.2%) and the RL gap (52.9% vs. 16.7%), as well as a higher number of reconnected right PVI-segments, all p < 0.05. On multivariate analysis, only the number of reconnected right PVI-segments was associated with ERAF (OR 4.26, p = 0.004). The ERAF following PVI + RL + MIL ablation was significantly related to 3-month PV-reconnections and the presence of RL gaps.
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spelling doaj.art-7699f128f6794494b2f002fb390455352022-12-21T18:01:37ZengNature PortfolioScientific Reports2045-23222018-06-018111010.1038/s41598-018-28072-yThe relationship of early recurrence of atrial fibrillation and the 3-month integrity of the ablation lesion setNebojša Mujović0Milan Marinković1Nebojša Marković2Vera Vučićević3Gregory Y. H. Lip4T. Jared Bunch5Tatjana S. Potpara6Cardiology Clinic, Clinical Center of SerbiaCardiology Clinic, Clinical Center of SerbiaCardiology Clinic, Clinical Center of SerbiaCenter for Anesthesiology and Reanimatology, Clinical Center of SerbiaCardiology Department, City HospitalIntermountain Medical Center Heart Institute, Intermountain Medical CenterCardiology Clinic, Clinical Center of SerbiaAbstract Early recurrence of atrial fibrillation (ERAF) after catheter-ablation (CA) can be a transient phenomenon due to inflammation, or a harbinger of late AF recurrence due to CA lesion (re)conduction. We studied the relationship between ERAF and the 3-month CA lesions integrity. Forty one consecutive AF patients who underwent a pulmonary vein isolation (PVI), roof line (RL) and mitral isthmus line (MIL) CA were enrolled. At 3 months all patients underwent invasive assessment of the lesion set integrity irrespective of ERAF. The PVI, RL and MIL ablation was successful in 100.0%, 95.1% and 82.9% patients, respectively. At the 3-month remapping, a gap in PVI-lesion(s), RL or MIL was identified in 61.0%, 31.7% and 36.6% patients, respectively. Patients with (n = 17, 41.5%) compared to those without ERAF (n = 24) had a significantly higher rate of any PV-reconnection (88.2% vs. 41.7%), the right PV(s)-reconnection (82.5% vs. 29.2%) and the RL gap (52.9% vs. 16.7%), as well as a higher number of reconnected right PVI-segments, all p < 0.05. On multivariate analysis, only the number of reconnected right PVI-segments was associated with ERAF (OR 4.26, p = 0.004). The ERAF following PVI + RL + MIL ablation was significantly related to 3-month PV-reconnections and the presence of RL gaps.https://doi.org/10.1038/s41598-018-28072-y
spellingShingle Nebojša Mujović
Milan Marinković
Nebojša Marković
Vera Vučićević
Gregory Y. H. Lip
T. Jared Bunch
Tatjana S. Potpara
The relationship of early recurrence of atrial fibrillation and the 3-month integrity of the ablation lesion set
Scientific Reports
title The relationship of early recurrence of atrial fibrillation and the 3-month integrity of the ablation lesion set
title_full The relationship of early recurrence of atrial fibrillation and the 3-month integrity of the ablation lesion set
title_fullStr The relationship of early recurrence of atrial fibrillation and the 3-month integrity of the ablation lesion set
title_full_unstemmed The relationship of early recurrence of atrial fibrillation and the 3-month integrity of the ablation lesion set
title_short The relationship of early recurrence of atrial fibrillation and the 3-month integrity of the ablation lesion set
title_sort relationship of early recurrence of atrial fibrillation and the 3 month integrity of the ablation lesion set
url https://doi.org/10.1038/s41598-018-28072-y
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