Inhibition of MLKL Attenuates Necroptotic Cell Death in a Murine Cell Model of Hepatic Ischaemia Injury

Inhibition of MLKL Attenuates Necroptotic Cell Death in a Murine Cell Model of Hepatic Ischaemia Injury

Background: Steatosis in donor livers poses a major risk of organ dysfunction due to their susceptibility to ischaemia-reperfusion (I/R) injury during transplant. Necroptosis, a novel form of programmed cell death, is orchestrated by receptor-interacting protein kinase 1 (RIPK1), receptor-interactin...

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Bibliographic Details
Main Authors: Raji Baidya, Jérémie Gautheron, Darrell H. G. Crawford, Haolu Wang, Kim R. Bridle
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Journal of Clinical Medicine
Subjects:
ischaemia-reperfusion injury
necroptosis
liver transplantation
steatosis
apoptosis
in vitro
Online Access:https://www.mdpi.com/2077-0383/10/2/212

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https://www.mdpi.com/2077-0383/10/2/212

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