Overcoming resolution attenuation during tilted cryo-EM data collection

Overcoming resolution attenuation during tilted cryo-EM data collection

Abstract Structural biology efforts using cryogenic electron microscopy are frequently stifled by specimens adopting “preferred orientations” on grids, leading to anisotropic map resolution and impeding structure determination. Tilting the specimen stage during data collection is a generalizable sol...

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Bibliographic Details
Main Authors: Sriram Aiyer, Philip R. Baldwin, Shi Min Tan, Zelin Shan, Juntaek Oh, Atousa Mehrani, Marianne E. Bowman, Gordon Louie, Dario Oliveira Passos, Selena Đorđević-Marquardt, Mario Mietzsch, Joshua A. Hull, Shuichi Hoshika, Benjamin A. Barad, Danielle A. Grotjahn, Robert McKenna, Mavis Agbandje-McKenna, Steven A. Benner, Joseph A. P. Noel, Dong Wang, Yong Zi Tan, Dmitry Lyumkis
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-44555-7

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