Characteristics of systemic inflammation and brain iron deposition in Parkinson's disease patients
Abstract Objective This study aimed at determining the characteristics of systemic inflammation and brain iron deposition in Parkinson's disease (PD) patients. Methods Thirty two PD patients and 30 gender‐ as well as age‐matched controls were enrolled. Serum interleukin (IL)‐1β, IL‐33, tumor ne...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-03-01
|
| Series: | Annals of Clinical and Translational Neurology |
| Online Access: | https://doi.org/10.1002/acn3.51512 |
| _version_ | 1818445921312047104 |
|---|---|
| author | Jinghui Xu Xiaofei He Yunqi Xu Xi Chen Mingyue Li Liying Zhang Xiaodi Fu Mengqiu Pan Qun Wang Xiquan Hu |
| author_facet | Jinghui Xu Xiaofei He Yunqi Xu Xi Chen Mingyue Li Liying Zhang Xiaodi Fu Mengqiu Pan Qun Wang Xiquan Hu |
| author_sort | Jinghui Xu |
| collection | DOAJ |
| description | Abstract Objective This study aimed at determining the characteristics of systemic inflammation and brain iron deposition in Parkinson's disease (PD) patients. Methods Thirty two PD patients and 30 gender‐ as well as age‐matched controls were enrolled. Serum interleukin (IL)‐1β, IL‐33, tumor necrosis factor (TNF)‐α, IL‐6, IL‐10, ferritin, iron, and total iron binding capacity (TIBC) levels were assayed. Quantitative susceptibility mapping (QSM) was used to quantitatively analyze brain iron accumulation in the regions of interest (ROIs). Correlations between concentrations of inflammatory cytokines and biomarkers for peripheral iron metabolism, brain iron deposition were evaluated in the PD group. Results Serum concentrations of IL‐1β and IL‐33 were found to be significantly elevated in the PD group compared to the control group, and in early‐stage PD group compared to advanced‐stage PD group. Total QSM value for bilateral ROIs was significantly elevated in the PD group compared to the control group, and in advanced‐stage PD group compared to early‐stage PD group. There was a significant inverse correlation between serum IL‐1β concentration and total QSM value for bilateral ROIs, between serum ferritin, iron, TIBC concentrations, and total QSM value for bilateral ROIs in PD patients. However, there was no significant correlation between serum IL‐1β concentrations and serum ferritin, iron, TIBC concentrations in PD patients. Interpretation The inflammatory state and chronic brain iron deposition progression in PD patients might be asynchronous. Alterations in systemic inflammation were not correlated with peripheral iron metabolism and might not contribute to the aggravation of brain iron deposition in PD patients. |
| first_indexed | 2024-12-14T19:39:30Z |
| format | Article |
| id | doaj.art-769c106e68204e4181cb075c4a3eb8f0 |
| institution | Directory Open Access Journal |
| issn | 2328-9503 |
| language | English |
| last_indexed | 2024-12-14T19:39:30Z |
| publishDate | 2022-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj.art-769c106e68204e4181cb075c4a3eb8f02022-12-21T22:49:44ZengWileyAnnals of Clinical and Translational Neurology2328-95032022-03-019327628510.1002/acn3.51512Characteristics of systemic inflammation and brain iron deposition in Parkinson's disease patientsJinghui Xu0Xiaofei He1Yunqi Xu2Xi Chen3Mingyue Li4Liying Zhang5Xiaodi Fu6Mengqiu Pan7Qun Wang8Xiquan Hu9Department of Rehabilitation Medicine, The Third Affiliated Hospital Sun Yat‐sen University Guangzhou ChinaDepartment of Rehabilitation Medicine, The Third Affiliated Hospital Sun Yat‐sen University Guangzhou ChinaDepartment of Neurology Nanfang Hospital, Southern Medical University Guangzhou ChinaDepartment of Rehabilitation Medicine, The Third Affiliated Hospital Sun Yat‐sen University Guangzhou ChinaDepartment of Rehabilitation Medicine, The Third Affiliated Hospital Sun Yat‐sen University Guangzhou ChinaDepartment of Rehabilitation Medicine, The Third Affiliated Hospital Sun Yat‐sen University Guangzhou ChinaDepartment of Neurology Nanfang Hospital, Southern Medical University Guangzhou ChinaDepartment of Neurology Guangdong 999 Brain Hospital Guangzhou ChinaDepartment of Neurology Nanfang Hospital, Southern Medical University Guangzhou ChinaDepartment of Rehabilitation Medicine, The Third Affiliated Hospital Sun Yat‐sen University Guangzhou ChinaAbstract Objective This study aimed at determining the characteristics of systemic inflammation and brain iron deposition in Parkinson's disease (PD) patients. Methods Thirty two PD patients and 30 gender‐ as well as age‐matched controls were enrolled. Serum interleukin (IL)‐1β, IL‐33, tumor necrosis factor (TNF)‐α, IL‐6, IL‐10, ferritin, iron, and total iron binding capacity (TIBC) levels were assayed. Quantitative susceptibility mapping (QSM) was used to quantitatively analyze brain iron accumulation in the regions of interest (ROIs). Correlations between concentrations of inflammatory cytokines and biomarkers for peripheral iron metabolism, brain iron deposition were evaluated in the PD group. Results Serum concentrations of IL‐1β and IL‐33 were found to be significantly elevated in the PD group compared to the control group, and in early‐stage PD group compared to advanced‐stage PD group. Total QSM value for bilateral ROIs was significantly elevated in the PD group compared to the control group, and in advanced‐stage PD group compared to early‐stage PD group. There was a significant inverse correlation between serum IL‐1β concentration and total QSM value for bilateral ROIs, between serum ferritin, iron, TIBC concentrations, and total QSM value for bilateral ROIs in PD patients. However, there was no significant correlation between serum IL‐1β concentrations and serum ferritin, iron, TIBC concentrations in PD patients. Interpretation The inflammatory state and chronic brain iron deposition progression in PD patients might be asynchronous. Alterations in systemic inflammation were not correlated with peripheral iron metabolism and might not contribute to the aggravation of brain iron deposition in PD patients.https://doi.org/10.1002/acn3.51512 |
| spellingShingle | Jinghui Xu Xiaofei He Yunqi Xu Xi Chen Mingyue Li Liying Zhang Xiaodi Fu Mengqiu Pan Qun Wang Xiquan Hu Characteristics of systemic inflammation and brain iron deposition in Parkinson's disease patients Annals of Clinical and Translational Neurology |
| title | Characteristics of systemic inflammation and brain iron deposition in Parkinson's disease patients |
| title_full | Characteristics of systemic inflammation and brain iron deposition in Parkinson's disease patients |
| title_fullStr | Characteristics of systemic inflammation and brain iron deposition in Parkinson's disease patients |
| title_full_unstemmed | Characteristics of systemic inflammation and brain iron deposition in Parkinson's disease patients |
| title_short | Characteristics of systemic inflammation and brain iron deposition in Parkinson's disease patients |
| title_sort | characteristics of systemic inflammation and brain iron deposition in parkinson s disease patients |
| url | https://doi.org/10.1002/acn3.51512 |
| work_keys_str_mv | AT jinghuixu characteristicsofsystemicinflammationandbrainirondepositioninparkinsonsdiseasepatients AT xiaofeihe characteristicsofsystemicinflammationandbrainirondepositioninparkinsonsdiseasepatients AT yunqixu characteristicsofsystemicinflammationandbrainirondepositioninparkinsonsdiseasepatients AT xichen characteristicsofsystemicinflammationandbrainirondepositioninparkinsonsdiseasepatients AT mingyueli characteristicsofsystemicinflammationandbrainirondepositioninparkinsonsdiseasepatients AT liyingzhang characteristicsofsystemicinflammationandbrainirondepositioninparkinsonsdiseasepatients AT xiaodifu characteristicsofsystemicinflammationandbrainirondepositioninparkinsonsdiseasepatients AT mengqiupan characteristicsofsystemicinflammationandbrainirondepositioninparkinsonsdiseasepatients AT qunwang characteristicsofsystemicinflammationandbrainirondepositioninparkinsonsdiseasepatients AT xiquanhu characteristicsofsystemicinflammationandbrainirondepositioninparkinsonsdiseasepatients |