Astragalus Polysaccharide RAP Selectively Attenuates Paclitaxel-Induced Cytotoxicity Toward RAW 264.7 Cells by Reversing Cell Cycle Arrest and Apoptosis

Astragalus Polysaccharide RAP Selectively Attenuates Paclitaxel-Induced Cytotoxicity Toward RAW 264.7 Cells by Reversing Cell Cycle Arrest and Apoptosis

Purpose: The purpose of this study was to determine if an Astragalus polysaccharide (RAP) can protect immune cells from the toxic side effects of paclitaxel (Taxol), a powerful anti-tumor drug whose equally powerful side effects limit its clinical use.Methods: We hypothesized that RAP can reduce the...

Full description

Bibliographic Details
Main Authors: Wan-Rong Bao, Zhi-Peng Li, Quan-Wei Zhang, Li-Feng Li, Hong-Bing Liu, Dik-Lung Ma, Chung-Hang Leung, Ai-Ping Lu, Zhao-Xiang Bian, Quan-Bin Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Pharmacology
Subjects:
Astragalus polysaccharide
cytotoxicity
protective effect
cell cycle
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01580/full

Similar Items

Similar Items