Quercetin and Related Analogs as Therapeutics to Promote Tissue Repair
Quercetin is a polyphenol of the flavonoid class of secondary metabolites that is widely distributed in the plant kingdom. Quercetin has been found to exhibit potent bioactivity in the areas of wound healing, neuroprotection, and anti-aging research. Naturally found in highly glycosylated forms, agl...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/10/10/1127 |
| _version_ | 1797574663118782464 |
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| author | Tina B. McKay Kyle A. Emmitte Carrie German Dimitrios Karamichos |
| author_facet | Tina B. McKay Kyle A. Emmitte Carrie German Dimitrios Karamichos |
| author_sort | Tina B. McKay |
| collection | DOAJ |
| description | Quercetin is a polyphenol of the flavonoid class of secondary metabolites that is widely distributed in the plant kingdom. Quercetin has been found to exhibit potent bioactivity in the areas of wound healing, neuroprotection, and anti-aging research. Naturally found in highly glycosylated forms, aglycone quercetin has low solubility in aqueous environments, which has heavily limited its clinical applications. To improve the stability and bioavailability of quercetin, efforts have been made to chemically modify quercetin and related flavonoids so as to improve aqueous solubility while retaining bioactivity. In this review, we provide an updated overview of the biological properties of quercetin and proposed mechanisms of actions in the context of wound healing and aging. We also provide a description of recent developments in synthetic approaches to improve the solubility and stability of quercetin and related analogs for therapeutic applications. Further research in these areas is expected to enable translational applications to improve ocular wound healing and tissue repair. |
| first_indexed | 2024-03-10T21:26:30Z |
| format | Article |
| id | doaj.art-769d6af6dc0c489588f30ac95380b3bf |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-10T21:26:30Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-769d6af6dc0c489588f30ac95380b3bf2023-11-19T15:41:20ZengMDPI AGBioengineering2306-53542023-09-011010112710.3390/bioengineering10101127Quercetin and Related Analogs as Therapeutics to Promote Tissue RepairTina B. McKay0Kyle A. Emmitte1Carrie German2Dimitrios Karamichos3Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114, USADepartment of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX 76107, USACFD Research Corporation, Computational Biology Division, Huntsville, AL 35806, USADepartment of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX 76107, USAQuercetin is a polyphenol of the flavonoid class of secondary metabolites that is widely distributed in the plant kingdom. Quercetin has been found to exhibit potent bioactivity in the areas of wound healing, neuroprotection, and anti-aging research. Naturally found in highly glycosylated forms, aglycone quercetin has low solubility in aqueous environments, which has heavily limited its clinical applications. To improve the stability and bioavailability of quercetin, efforts have been made to chemically modify quercetin and related flavonoids so as to improve aqueous solubility while retaining bioactivity. In this review, we provide an updated overview of the biological properties of quercetin and proposed mechanisms of actions in the context of wound healing and aging. We also provide a description of recent developments in synthetic approaches to improve the solubility and stability of quercetin and related analogs for therapeutic applications. Further research in these areas is expected to enable translational applications to improve ocular wound healing and tissue repair.https://www.mdpi.com/2306-5354/10/10/1127flavonoidsfibrosiscorneaquercetinwound healingaging |
| spellingShingle | Tina B. McKay Kyle A. Emmitte Carrie German Dimitrios Karamichos Quercetin and Related Analogs as Therapeutics to Promote Tissue Repair Bioengineering flavonoids fibrosis cornea quercetin wound healing aging |
| title | Quercetin and Related Analogs as Therapeutics to Promote Tissue Repair |
| title_full | Quercetin and Related Analogs as Therapeutics to Promote Tissue Repair |
| title_fullStr | Quercetin and Related Analogs as Therapeutics to Promote Tissue Repair |
| title_full_unstemmed | Quercetin and Related Analogs as Therapeutics to Promote Tissue Repair |
| title_short | Quercetin and Related Analogs as Therapeutics to Promote Tissue Repair |
| title_sort | quercetin and related analogs as therapeutics to promote tissue repair |
| topic | flavonoids fibrosis cornea quercetin wound healing aging |
| url | https://www.mdpi.com/2306-5354/10/10/1127 |
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