Effects of <i>Irvingia gabonensis</i> Extract on Metabolism, Antioxidants, Adipocytokines, Telomere Length, and Aerobic Capacity in Overweight/Obese Individuals
We investigated the effects of <i>Irvingia gabonensis</i> (IG) kernel extract on the metabolism, adiposity indices, redox status, inflammation, adipocytokines, blood leukocyte relative telomere length (RTL), and aerobic capacity of overweight/obese individuals. All participants used the...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/21/4646 |
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| author | Rujira Nonsa-ard Ploypailin Aneknan Terdthai Tong-un Sittisak Honsawek Naruemon Leelayuwat |
| author_facet | Rujira Nonsa-ard Ploypailin Aneknan Terdthai Tong-un Sittisak Honsawek Naruemon Leelayuwat |
| author_sort | Rujira Nonsa-ard |
| collection | DOAJ |
| description | We investigated the effects of <i>Irvingia gabonensis</i> (IG) kernel extract on the metabolism, adiposity indices, redox status, inflammation, adipocytokines, blood leukocyte relative telomere length (RTL), and aerobic capacity of overweight/obese individuals. All participants used the first 12-week phase to monitor body weight. They were then randomly divided into two groups: (1) 300 mg IG or (2) placebo (PLA). Both groups took one tablet per day for 12 weeks. The variables were measured before supplementation and after 3, 6, and 12 weeks of supplementation. RTL and aerobic capacity were measured before and after 12 weeks. Compared with the PLA, the IG increased plasma vitamin C after supplementation at 6 (<i>p</i> < 0.01) and 12 weeks (<i>p</i> < 0.05) and serum adiponectin after 3 weeks (<i>p</i> < 0.05). Compared with before supplementation, plasma malondialdehyde in the IG and serum leptin in the PLA were decreased after 12-week supplementation, without any differences between the groups. There were no differences between groups with respect to metabolism, inflammation, RTL, and aerobic capacity after the supplementation. We suggest that 12-week daily IG supplementation improved plasma vitamin C and adiponectin. The findings show the possible mechanism contributing to the effect of IG supplementation on a reduction in obesity-related complications. |
| first_indexed | 2024-03-09T18:46:04Z |
| format | Article |
| id | doaj.art-769f407308c040baad0bceeb0373318e |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T18:46:04Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-769f407308c040baad0bceeb0373318e2023-11-24T06:14:55ZengMDPI AGNutrients2072-66432022-11-011421464610.3390/nu14214646Effects of <i>Irvingia gabonensis</i> Extract on Metabolism, Antioxidants, Adipocytokines, Telomere Length, and Aerobic Capacity in Overweight/Obese IndividualsRujira Nonsa-ard0Ploypailin Aneknan1Terdthai Tong-un2Sittisak Honsawek3Naruemon Leelayuwat4Biomedical Sciences Program, Graduate School, Khon Kaen University, Khon Kaen 40002, ThailandExercise and Sport Sciences Development and Research Group, Khon Kaen University, Khon Kaen 40002, ThailandDepartment of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, ThailandCenter of Excellence in Osteoarthritis and Musculoskeleton, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, ThailandGraduate School, Khon Kaen University, Khon Kaen 40002, ThailandWe investigated the effects of <i>Irvingia gabonensis</i> (IG) kernel extract on the metabolism, adiposity indices, redox status, inflammation, adipocytokines, blood leukocyte relative telomere length (RTL), and aerobic capacity of overweight/obese individuals. All participants used the first 12-week phase to monitor body weight. They were then randomly divided into two groups: (1) 300 mg IG or (2) placebo (PLA). Both groups took one tablet per day for 12 weeks. The variables were measured before supplementation and after 3, 6, and 12 weeks of supplementation. RTL and aerobic capacity were measured before and after 12 weeks. Compared with the PLA, the IG increased plasma vitamin C after supplementation at 6 (<i>p</i> < 0.01) and 12 weeks (<i>p</i> < 0.05) and serum adiponectin after 3 weeks (<i>p</i> < 0.05). Compared with before supplementation, plasma malondialdehyde in the IG and serum leptin in the PLA were decreased after 12-week supplementation, without any differences between the groups. There were no differences between groups with respect to metabolism, inflammation, RTL, and aerobic capacity after the supplementation. We suggest that 12-week daily IG supplementation improved plasma vitamin C and adiponectin. The findings show the possible mechanism contributing to the effect of IG supplementation on a reduction in obesity-related complications.https://www.mdpi.com/2072-6643/14/21/4646<i>Irvingia gabonensis</i>ascorbic acidmalondialdehydeadiponectinbody mass indexsubstrate utilization |
| spellingShingle | Rujira Nonsa-ard Ploypailin Aneknan Terdthai Tong-un Sittisak Honsawek Naruemon Leelayuwat Effects of <i>Irvingia gabonensis</i> Extract on Metabolism, Antioxidants, Adipocytokines, Telomere Length, and Aerobic Capacity in Overweight/Obese Individuals Nutrients <i>Irvingia gabonensis</i> ascorbic acid malondialdehyde adiponectin body mass index substrate utilization |
| title | Effects of <i>Irvingia gabonensis</i> Extract on Metabolism, Antioxidants, Adipocytokines, Telomere Length, and Aerobic Capacity in Overweight/Obese Individuals |
| title_full | Effects of <i>Irvingia gabonensis</i> Extract on Metabolism, Antioxidants, Adipocytokines, Telomere Length, and Aerobic Capacity in Overweight/Obese Individuals |
| title_fullStr | Effects of <i>Irvingia gabonensis</i> Extract on Metabolism, Antioxidants, Adipocytokines, Telomere Length, and Aerobic Capacity in Overweight/Obese Individuals |
| title_full_unstemmed | Effects of <i>Irvingia gabonensis</i> Extract on Metabolism, Antioxidants, Adipocytokines, Telomere Length, and Aerobic Capacity in Overweight/Obese Individuals |
| title_short | Effects of <i>Irvingia gabonensis</i> Extract on Metabolism, Antioxidants, Adipocytokines, Telomere Length, and Aerobic Capacity in Overweight/Obese Individuals |
| title_sort | effects of i irvingia gabonensis i extract on metabolism antioxidants adipocytokines telomere length and aerobic capacity in overweight obese individuals |
| topic | <i>Irvingia gabonensis</i> ascorbic acid malondialdehyde adiponectin body mass index substrate utilization |
| url | https://www.mdpi.com/2072-6643/14/21/4646 |
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