Lack of involvement of known DNA methyltransferases in familial hydatidiform mole implies the involvement of other factors in establishment of imprinting in the human female germline

Lack of involvement of known DNA methyltransferases in familial hydatidiform mole implies the involvement of other factors in establishment of imprinting in the human female germline

<p>Abstract</p> <p>Background</p> <p>Differential methylation of the two alleles is a hallmark of imprinted genes. Correspondingly, loss of DNA methyltransferase function results in aberrant imprinting and abnormal post-fertilization development. In the mouse, mutations...

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Bibliographic Details
Main Authors: Picton H M, Huntriss J, Hodge D, Judson H, De Vos M, Hayward B E, Sheridan E, Bonthron DT
Format: Article
Language:English
Published: BMC 2003-01-01
Series:BMC Genetics
Subjects:
autozygosity
hydatidiform mole
imprinting
oogenesis
Online Access:http://www.biomedcentral.com/1471-2156/4/2

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