The counter regulatory response induced by CpG oligonucleotides prevents bleomycin induced pneumopathy

The counter regulatory response induced by CpG oligonucleotides prevents bleomycin induced pneumopathy

<p>Abstract</p> <p>Bleomycin (BLM) induces life-threatening pneumonitis and pulmonary fibrosis in 20% of patients, limiting its use as a chemotherapeutic agent. Oligonucleotides expressing immunostimulatory CpG motifs (CpG ODN) stimulate cells that express Toll-like receptor 9 to i...

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Bibliographic Details
Main Authors: Kinjo Takeshi, Tomaru Koji, Haines Diana C, Klinman Dennis M
Format: Article
Language:English
Published: BMC 2012-06-01
Series:Respiratory Research
Subjects:
Bleomycin
Pneumonitis
Fibrosis
CpG oligonucleotide
Online Access:http://respiratory-research.com/content/13/1/47

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