Carbamazepine-induced Life-threatening Stevens-Johnson Syndrome and Agranulocytosis: The Maiden Case
Stevens-Johnson syndrome is one of the few dermatological emergencies in clinical practice. The syndrome is often secondary to the usage of drugs, of which allopurinol, penicillins, sulfa drugs, ibuprofen, sodium valproate, phenytoin, lamotrigine and carbamazepine are commonly implicated. Agranulo...
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JCDR Research and Publications Private Limited
2016-12-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/9065/23748_CE(Ra1)_F(Sh)_P(RB_RK)_PFA(AK)_PF2(PAG).pdf |
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| author | A. Avinash V. Mohanbabu Amberkar Sushil Kiran Kunder Sharath Madhyastha K. Meenakumari |
| author_facet | A. Avinash V. Mohanbabu Amberkar Sushil Kiran Kunder Sharath Madhyastha K. Meenakumari |
| author_sort | A. Avinash |
| collection | DOAJ |
| description | Stevens-Johnson syndrome is one of the few dermatological emergencies in clinical practice. The syndrome is often secondary to the
usage of drugs, of which allopurinol, penicillins, sulfa drugs, ibuprofen, sodium valproate, phenytoin, lamotrigine and carbamazepine
are commonly implicated. Agranulocytosis is the existence of a clinically significant reduction in neutrophil count. This condition is a
serious threat to the patient, as he/she is at a greater risk of contracting bacterial or fungal infections, which may prove to be fatal.
The co-existence of Stevens-Johnson syndrome and agranulocytosis in the same patient further increases the risk of morbidity and
mortality. To the best of our knowledge, there are no reports available in the existing literature, of cases that were reported with both
these life-threatening conditions in a single patient, at the same point of time. This is a case narrative of a patient who presented with
both Stevens-Johnson syndrome and agranulocytosis, following the administration of carbamazepine The patient’s differential leucocyte
count revealed a neutrophil proportion of 2.33%. A causality assessment done using Naranjo’s algorithm showed that carbamazepine
“definitely” caused Agranulocytosis and “probably” caused Stevens-Johnson syndrome. |
| first_indexed | 2024-12-13T15:27:08Z |
| format | Article |
| id | doaj.art-76a27c2f440f4e8eb3c17deb93be01de |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-13T15:27:08Z |
| publishDate | 2016-12-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-76a27c2f440f4e8eb3c17deb93be01de2022-12-21T23:40:17ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2016-12-011012FD01FD0310.7860/JCDR/2016/23748.9065Carbamazepine-induced Life-threatening Stevens-Johnson Syndrome and Agranulocytosis: The Maiden CaseA. Avinash0V. Mohanbabu Amberkar1Sushil Kiran Kunder2Sharath Madhyastha3K. Meenakumari4Postgraduate, Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.Associate Professor, Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.Postgraduate, Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.Assistant Professor, Department of Medicine, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.Associate Professor, Department of Pharmacology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.Stevens-Johnson syndrome is one of the few dermatological emergencies in clinical practice. The syndrome is often secondary to the usage of drugs, of which allopurinol, penicillins, sulfa drugs, ibuprofen, sodium valproate, phenytoin, lamotrigine and carbamazepine are commonly implicated. Agranulocytosis is the existence of a clinically significant reduction in neutrophil count. This condition is a serious threat to the patient, as he/she is at a greater risk of contracting bacterial or fungal infections, which may prove to be fatal. The co-existence of Stevens-Johnson syndrome and agranulocytosis in the same patient further increases the risk of morbidity and mortality. To the best of our knowledge, there are no reports available in the existing literature, of cases that were reported with both these life-threatening conditions in a single patient, at the same point of time. This is a case narrative of a patient who presented with both Stevens-Johnson syndrome and agranulocytosis, following the administration of carbamazepine The patient’s differential leucocyte count revealed a neutrophil proportion of 2.33%. A causality assessment done using Naranjo’s algorithm showed that carbamazepine “definitely” caused Agranulocytosis and “probably” caused Stevens-Johnson syndrome.https://jcdr.net/articles/PDF/9065/23748_CE(Ra1)_F(Sh)_P(RB_RK)_PFA(AK)_PF2(PAG).pdfanticonvulsantantiepileptichypersensitivityrashskin |
| spellingShingle | A. Avinash V. Mohanbabu Amberkar Sushil Kiran Kunder Sharath Madhyastha K. Meenakumari Carbamazepine-induced Life-threatening Stevens-Johnson Syndrome and Agranulocytosis: The Maiden Case Journal of Clinical and Diagnostic Research anticonvulsant antiepileptic hypersensitivity rash skin |
| title | Carbamazepine-induced Life-threatening Stevens-Johnson Syndrome and Agranulocytosis: The Maiden Case |
| title_full | Carbamazepine-induced Life-threatening Stevens-Johnson Syndrome and Agranulocytosis: The Maiden Case |
| title_fullStr | Carbamazepine-induced Life-threatening Stevens-Johnson Syndrome and Agranulocytosis: The Maiden Case |
| title_full_unstemmed | Carbamazepine-induced Life-threatening Stevens-Johnson Syndrome and Agranulocytosis: The Maiden Case |
| title_short | Carbamazepine-induced Life-threatening Stevens-Johnson Syndrome and Agranulocytosis: The Maiden Case |
| title_sort | carbamazepine induced life threatening stevens johnson syndrome and agranulocytosis the maiden case |
| topic | anticonvulsant antiepileptic hypersensitivity rash skin |
| url | https://jcdr.net/articles/PDF/9065/23748_CE(Ra1)_F(Sh)_P(RB_RK)_PFA(AK)_PF2(PAG).pdf |
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