The curious case of Prevotella copri
ABSTRACTPrevotella copri is an abundant member of the human gastrointestinal microbiome, whose relative abundance has curiously been associated with positive and negative impacts on diseases, such as Parkinson’s disease and rheumatoid arthritis. Yet, the verdict is still out on the definitive role o...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
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| Series: | Gut Microbes |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2023.2249152 |
| _version_ | 1797320560285319168 |
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| author | Nehal Adel Abdelsalam Shaimaa M. Hegazy Ramy K. Aziz |
| author_facet | Nehal Adel Abdelsalam Shaimaa M. Hegazy Ramy K. Aziz |
| author_sort | Nehal Adel Abdelsalam |
| collection | DOAJ |
| description | ABSTRACTPrevotella copri is an abundant member of the human gastrointestinal microbiome, whose relative abundance has curiously been associated with positive and negative impacts on diseases, such as Parkinson’s disease and rheumatoid arthritis. Yet, the verdict is still out on the definitive role of P. copri in human health, and on the effect of different diets on its relative abundance in the gut microbiome. The puzzling discrepancies among P. copri studies have only recently been attributed to the diversity of its strains, which substantially differ in their encoded metabolic patterns from the commonly used reference strain. However, such strain differences cannot be resolved by common 16S rRNA amplicon profiling methods. Here, we scrutinize P. copri, its versatile metabolic potential, and the hypotheses behind the conflicting observations on its association with diet and human health. We also provide suggestions for designing studies and bioinformatics pipelines to better research P. copri. |
| first_indexed | 2024-03-08T04:40:57Z |
| format | Article |
| id | doaj.art-76a335cb768b4e46837ce7e988bda93f |
| institution | Directory Open Access Journal |
| issn | 1949-0976 1949-0984 |
| language | English |
| last_indexed | 2024-03-08T04:40:57Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj.art-76a335cb768b4e46837ce7e988bda93f2024-02-08T12:02:08ZengTaylor & Francis GroupGut Microbes1949-09761949-09842023-12-0115210.1080/19490976.2023.2249152The curious case of Prevotella copriNehal Adel Abdelsalam0Shaimaa M. Hegazy1Ramy K. Aziz2Biomedical Sciences, Zewail City of Science and Technology, Giza, EgyptMicrobiology and Immunology Research Program, Children’s Cancer Hospital Egypt 57357, Cairo, EgyptMicrobiology and Immunology Research Program, Children’s Cancer Hospital Egypt 57357, Cairo, EgyptABSTRACTPrevotella copri is an abundant member of the human gastrointestinal microbiome, whose relative abundance has curiously been associated with positive and negative impacts on diseases, such as Parkinson’s disease and rheumatoid arthritis. Yet, the verdict is still out on the definitive role of P. copri in human health, and on the effect of different diets on its relative abundance in the gut microbiome. The puzzling discrepancies among P. copri studies have only recently been attributed to the diversity of its strains, which substantially differ in their encoded metabolic patterns from the commonly used reference strain. However, such strain differences cannot be resolved by common 16S rRNA amplicon profiling methods. Here, we scrutinize P. copri, its versatile metabolic potential, and the hypotheses behind the conflicting observations on its association with diet and human health. We also provide suggestions for designing studies and bioinformatics pipelines to better research P. copri.https://www.tandfonline.com/doi/10.1080/19490976.2023.2249152microbiomedietmetabolismgenomic variationpharmacomicrobiomicstoxicomicrobiomics |
| spellingShingle | Nehal Adel Abdelsalam Shaimaa M. Hegazy Ramy K. Aziz The curious case of Prevotella copri Gut Microbes microbiome diet metabolism genomic variation pharmacomicrobiomics toxicomicrobiomics |
| title | The curious case of Prevotella copri |
| title_full | The curious case of Prevotella copri |
| title_fullStr | The curious case of Prevotella copri |
| title_full_unstemmed | The curious case of Prevotella copri |
| title_short | The curious case of Prevotella copri |
| title_sort | curious case of prevotella copri |
| topic | microbiome diet metabolism genomic variation pharmacomicrobiomics toxicomicrobiomics |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2023.2249152 |
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