Efficacy and safety of bivalirudin bridging enoxaparin versus fondaparinux in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention: evidence from a single-center study
Introduction This study aims to compare the safety and efficacy of bivalirudin bridging enoxaparin versus fondaparinux in patients with acute myocardial infarction (AMI) who were undergoing primary percutaneous coronary intervention (PPCI). Material and methods The study is a prospective, natural,...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2023-01-01
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| Series: | Archives of Medical Science |
| Subjects: | |
| Online Access: | https://www.archivesofmedicalscience.com/Efficacy-and-safety-of-bivalirudin-bridging-enoxaparin-versus-fondaparinux-in-patients,157287,0,2.html |
| _version_ | 1827620371466027008 |
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| author | Yanqing Guo Jingping Wang Zhixin Wang Li Li Jian An |
| author_facet | Yanqing Guo Jingping Wang Zhixin Wang Li Li Jian An |
| author_sort | Yanqing Guo |
| collection | DOAJ |
| description | Introduction
This study aims to compare the safety and efficacy of bivalirudin bridging enoxaparin versus fondaparinux in patients with acute myocardial infarction (AMI) who were undergoing primary percutaneous coronary intervention (PPCI).
Material and methods
The study is a prospective, natural, and selective interventional trial based on real-world data for 482 AMI patients.
Results
At the end of the follow-up, the two groups demonstrated similar major adverse cardiovascular and cerebrovascular events (MACCE) and bleeding rates. After propensity score matching (PSM), the fondaparinux group showed greater advantages in reducing MACCE and bleeding events.
Conclusions
The anticoagulation strategy of bivalirudin bridging fondaparinux seems to be superior to that of bivalirudin bridging enoxaparin in patients with AMI undergoing PPCI. |
| first_indexed | 2024-03-09T10:46:32Z |
| format | Article |
| id | doaj.art-76a4064d355b436e800409c725b29b0c |
| institution | Directory Open Access Journal |
| issn | 1734-1922 1896-9151 |
| language | English |
| last_indexed | 2024-03-09T10:46:32Z |
| publishDate | 2023-01-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj.art-76a4064d355b436e800409c725b29b0c2023-12-01T09:55:34ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512023-01-0119124224910.5114/aoms/157287157287Efficacy and safety of bivalirudin bridging enoxaparin versus fondaparinux in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention: evidence from a single-center studyYanqing Guo0Jingping Wang1Zhixin Wang2Li Li3Jian An4Department of Cardiology, Shanxi Cardiovascular Hospital, Taiyuan, Shanxi, ChinaDepartment of Cardiology, Shanxi Cardiovascular Hospital, Taiyuan, Shanxi, ChinaDepartment of Cardiology, Shanxi Cardiovascular Hospital, Taiyuan, Shanxi, ChinaDepartment of Cardiology, Shanxi Cardiovascular Hospital, Taiyuan, Shanxi, ChinaDepartment of Cardiology, Shanxi Cardiovascular Hospital, Taiyuan, Shanxi, ChinaIntroduction This study aims to compare the safety and efficacy of bivalirudin bridging enoxaparin versus fondaparinux in patients with acute myocardial infarction (AMI) who were undergoing primary percutaneous coronary intervention (PPCI). Material and methods The study is a prospective, natural, and selective interventional trial based on real-world data for 482 AMI patients. Results At the end of the follow-up, the two groups demonstrated similar major adverse cardiovascular and cerebrovascular events (MACCE) and bleeding rates. After propensity score matching (PSM), the fondaparinux group showed greater advantages in reducing MACCE and bleeding events. Conclusions The anticoagulation strategy of bivalirudin bridging fondaparinux seems to be superior to that of bivalirudin bridging enoxaparin in patients with AMI undergoing PPCI.https://www.archivesofmedicalscience.com/Efficacy-and-safety-of-bivalirudin-bridging-enoxaparin-versus-fondaparinux-in-patients,157287,0,2.htmlfondaparinuxbivalirudinenoxaparinacute myocardial infarctionprimary percutaneous coronary intervention |
| spellingShingle | Yanqing Guo Jingping Wang Zhixin Wang Li Li Jian An Efficacy and safety of bivalirudin bridging enoxaparin versus fondaparinux in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention: evidence from a single-center study Archives of Medical Science fondaparinux bivalirudin enoxaparin acute myocardial infarction primary percutaneous coronary intervention |
| title | Efficacy and safety of bivalirudin bridging enoxaparin versus fondaparinux in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention: evidence from a single-center study |
| title_full | Efficacy and safety of bivalirudin bridging enoxaparin versus fondaparinux in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention: evidence from a single-center study |
| title_fullStr | Efficacy and safety of bivalirudin bridging enoxaparin versus fondaparinux in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention: evidence from a single-center study |
| title_full_unstemmed | Efficacy and safety of bivalirudin bridging enoxaparin versus fondaparinux in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention: evidence from a single-center study |
| title_short | Efficacy and safety of bivalirudin bridging enoxaparin versus fondaparinux in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention: evidence from a single-center study |
| title_sort | efficacy and safety of bivalirudin bridging enoxaparin versus fondaparinux in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention evidence from a single center study |
| topic | fondaparinux bivalirudin enoxaparin acute myocardial infarction primary percutaneous coronary intervention |
| url | https://www.archivesofmedicalscience.com/Efficacy-and-safety-of-bivalirudin-bridging-enoxaparin-versus-fondaparinux-in-patients,157287,0,2.html |
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