Clinical and virological features of Dengue in Vietnamese infants.
Infants account for a small proportion of the overall dengue case burden in endemic countries but can be clinically more difficult to manage. The clinical and laboratory features in infants with dengue have not been extensively characterised.This prospective, cross-sectional descriptive study of inf...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2010-04-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | http://europepmc.org/articles/PMC2854125?pdf=render |
| _version_ | 1818060235803197440 |
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| author | Tran Nguyen Bich Chau Katherine L Anders Le Bich Lien Nguyen Thanh Hung Lu Thi Minh Hieu Nguyen Minh Tuan Tran Thi Thuy Le Thi Phuong Nguyen Thi Hong Tham Mai Ngoc Lanh Jeremy J Farrar Stephen S Whitehead Cameron P Simmons |
| author_facet | Tran Nguyen Bich Chau Katherine L Anders Le Bich Lien Nguyen Thanh Hung Lu Thi Minh Hieu Nguyen Minh Tuan Tran Thi Thuy Le Thi Phuong Nguyen Thi Hong Tham Mai Ngoc Lanh Jeremy J Farrar Stephen S Whitehead Cameron P Simmons |
| author_sort | Tran Nguyen Bich Chau |
| collection | DOAJ |
| description | Infants account for a small proportion of the overall dengue case burden in endemic countries but can be clinically more difficult to manage. The clinical and laboratory features in infants with dengue have not been extensively characterised.This prospective, cross-sectional descriptive study of infants hospitalized with dengue was conducted in Vietnam from November 2004 to December 2007. More than two-thirds of 303 infants enrolled on clinical suspicion of dengue had a serologically confirmed dengue virus (DENV) infection. Almost all were primary dengue infections and 80% of the infants developed DHF/DSS. At the time of presentation and during hospitalization, the clinical signs and symptoms in infants with dengue were difficult to distinguish from those with other febrile illnesses, suggesting that in infants early laboratory confirmation could assist appropriate management. Detection of plasma NS1 antigen was found to be a sensitive marker of acute dengue in infants with primary infection, especially in the first few days of illness.Collectively, these results provide a systematic description of the clinical features of dengue in infants and highlight the value of NS1 detection for diagnosis. |
| first_indexed | 2024-12-10T13:29:12Z |
| format | Article |
| id | doaj.art-76a6a1903b0543f5bad5cf0540f8730a |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-12-10T13:29:12Z |
| publishDate | 2010-04-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-76a6a1903b0543f5bad5cf0540f8730a2022-12-22T01:47:03ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352010-04-0144e65710.1371/journal.pntd.0000657Clinical and virological features of Dengue in Vietnamese infants.Tran Nguyen Bich ChauKatherine L AndersLe Bich LienNguyen Thanh HungLu Thi Minh HieuNguyen Minh TuanTran Thi ThuyLe Thi PhuongNguyen Thi Hong ThamMai Ngoc LanhJeremy J FarrarStephen S WhiteheadCameron P SimmonsInfants account for a small proportion of the overall dengue case burden in endemic countries but can be clinically more difficult to manage. The clinical and laboratory features in infants with dengue have not been extensively characterised.This prospective, cross-sectional descriptive study of infants hospitalized with dengue was conducted in Vietnam from November 2004 to December 2007. More than two-thirds of 303 infants enrolled on clinical suspicion of dengue had a serologically confirmed dengue virus (DENV) infection. Almost all were primary dengue infections and 80% of the infants developed DHF/DSS. At the time of presentation and during hospitalization, the clinical signs and symptoms in infants with dengue were difficult to distinguish from those with other febrile illnesses, suggesting that in infants early laboratory confirmation could assist appropriate management. Detection of plasma NS1 antigen was found to be a sensitive marker of acute dengue in infants with primary infection, especially in the first few days of illness.Collectively, these results provide a systematic description of the clinical features of dengue in infants and highlight the value of NS1 detection for diagnosis.http://europepmc.org/articles/PMC2854125?pdf=render |
| spellingShingle | Tran Nguyen Bich Chau Katherine L Anders Le Bich Lien Nguyen Thanh Hung Lu Thi Minh Hieu Nguyen Minh Tuan Tran Thi Thuy Le Thi Phuong Nguyen Thi Hong Tham Mai Ngoc Lanh Jeremy J Farrar Stephen S Whitehead Cameron P Simmons Clinical and virological features of Dengue in Vietnamese infants. PLoS Neglected Tropical Diseases |
| title | Clinical and virological features of Dengue in Vietnamese infants. |
| title_full | Clinical and virological features of Dengue in Vietnamese infants. |
| title_fullStr | Clinical and virological features of Dengue in Vietnamese infants. |
| title_full_unstemmed | Clinical and virological features of Dengue in Vietnamese infants. |
| title_short | Clinical and virological features of Dengue in Vietnamese infants. |
| title_sort | clinical and virological features of dengue in vietnamese infants |
| url | http://europepmc.org/articles/PMC2854125?pdf=render |
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