Birth mode is associated with development of atopic dermatitis in infancy and early childhood
Background: Birth by caesarean section (CS) is associated with development of allergic diseases, but its role in the development of atopic dermatitis (AD) is less convincing. Objective: Our primary aim was to determine if birth mode was associated with AD in 3-year-olds and secondarily to determine...
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| Format: | Article |
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Elsevier
2023-08-01
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| Series: | Journal of Allergy and Clinical Immunology: Global |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772829323000292 |
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| author | Sveinung T. Hoel, MD Johanna Wiik, MD, PhD Karin C.L. Carlsen, MD, PhD Kim M.A. Endre, MD, PhD Hrefna Katrín Gudmundsdóttir, MD Guttorm Haugen, MD, PhD Angela Hoyer, MSc Christine Monceyron Jonassen, PhD Marissa LeBlanc, MSc, PhD Björn Nordlund, RN, PhD Knut Rudi, PhD Håvard O. Skjerven, MD, PhD Anne Cathrine Staff, MD, PhD Gunilla Hedlin, MD, PhD Cilla Söderhäll, MSc, PhD Riyas Vettukattil, MD, PhD Hilde Aaneland, RN Eva M. Rehbinder, MD, PhD |
| author_facet | Sveinung T. Hoel, MD Johanna Wiik, MD, PhD Karin C.L. Carlsen, MD, PhD Kim M.A. Endre, MD, PhD Hrefna Katrín Gudmundsdóttir, MD Guttorm Haugen, MD, PhD Angela Hoyer, MSc Christine Monceyron Jonassen, PhD Marissa LeBlanc, MSc, PhD Björn Nordlund, RN, PhD Knut Rudi, PhD Håvard O. Skjerven, MD, PhD Anne Cathrine Staff, MD, PhD Gunilla Hedlin, MD, PhD Cilla Söderhäll, MSc, PhD Riyas Vettukattil, MD, PhD Hilde Aaneland, RN Eva M. Rehbinder, MD, PhD |
| author_sort | Sveinung T. Hoel, MD |
| collection | DOAJ |
| description | Background: Birth by caesarean section (CS) is associated with development of allergic diseases, but its role in the development of atopic dermatitis (AD) is less convincing. Objective: Our primary aim was to determine if birth mode was associated with AD in 3-year-olds and secondarily to determine if birth mode was associated with early onset and/or persistent AD in the first 3 years of life. Methods: We included 2129 mother–child pairs from the Scandinavian population-based prospective PreventADALL cohort with information on birth mode including vaginal birth, either traditional (81.3%) or in water (4.0%), and CS before (6.3%) and after (8.5%) onset of labor. We defined early onset AD as eczema at 3 months and AD diagnosis by 3 years of age. Persistent AD was defined as eczema both in the first year and at 3 years of age, together with an AD diagnosis by 3 years of age. Results: AD was diagnosed at 3, 6, 12, 24, and/or 36 months in 531 children (25%). Compared to vaginal delivery, CS was overall associated with increased odds of AD by 3 years of age, with adjusted odds ratio (95% confidence interval) of 1.33 (1.02-1.74), and higher odds of early onset AD (1.63, 1.06-2.48). The highest odds for early onset AD were observed in infants born by CS after onset of labor (1.83, 1.09-3.07). Birth mode was not associated with persistent AD. Conclusion: CS was associated with increased odds of AD by 3 years of age, particularly in infants presenting with eczema at 3 months of age. |
| first_indexed | 2024-03-12T15:30:34Z |
| format | Article |
| id | doaj.art-76a7e7482de24d769c006d329885d417 |
| institution | Directory Open Access Journal |
| issn | 2772-8293 |
| language | English |
| last_indexed | 2024-03-12T15:30:34Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Allergy and Clinical Immunology: Global |
| spelling | doaj.art-76a7e7482de24d769c006d329885d4172023-08-10T04:35:08ZengElsevierJournal of Allergy and Clinical Immunology: Global2772-82932023-08-0123100104Birth mode is associated with development of atopic dermatitis in infancy and early childhoodSveinung T. Hoel, MD0Johanna Wiik, MD, PhD1Karin C.L. Carlsen, MD, PhD2Kim M.A. Endre, MD, PhD3Hrefna Katrín Gudmundsdóttir, MD4Guttorm Haugen, MD, PhD5Angela Hoyer, MSc6Christine Monceyron Jonassen, PhD7Marissa LeBlanc, MSc, PhD8Björn Nordlund, RN, PhD9Knut Rudi, PhD10Håvard O. Skjerven, MD, PhD11Anne Cathrine Staff, MD, PhD12Gunilla Hedlin, MD, PhD13Cilla Söderhäll, MSc, PhD14Riyas Vettukattil, MD, PhD15Hilde Aaneland, RN16Eva M. Rehbinder, MD, PhD17Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Corresponding author: Sveinung Torsteinsen Hoel, MD, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.Department of Gynecology and Obstetrics, Østfold Hospital Trust, Kalnes, Norway; Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, SwedenInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, NorwayInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Dermatology and Vaenerology, Oslo University Hospital, Oslo, NorwayInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, NorwayInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Division of Obstetrics and Gynaecology, Oslo University Hospital, Oslo, NorwayAstrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm, Sweden; Department of Women’s and Children’s Health, Karolinska Institute, Stockholm, SwedenCentre for Laboratory Medicine, Østfold Hospital Trust, Grålum, Norway; Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, NorwayOslo Centre for Biostatistics and Epidemiology, Oslo University Hospital, Oslo, NorwayAstrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm, Sweden; Department of Women’s and Children’s Health, Karolinska Institute, Stockholm, SwedenFaculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, NorwayInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, NorwayInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Division of Obstetrics and Gynaecology, Oslo University Hospital, Oslo, NorwayAstrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm, Sweden; Department of Women’s and Children’s Health, Karolinska Institute, Stockholm, SwedenAstrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm, Sweden; Department of Women’s and Children’s Health, Karolinska Institute, Stockholm, SwedenInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, NorwayInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, NorwayInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Dermatology and Vaenerology, Oslo University Hospital, Oslo, NorwayBackground: Birth by caesarean section (CS) is associated with development of allergic diseases, but its role in the development of atopic dermatitis (AD) is less convincing. Objective: Our primary aim was to determine if birth mode was associated with AD in 3-year-olds and secondarily to determine if birth mode was associated with early onset and/or persistent AD in the first 3 years of life. Methods: We included 2129 mother–child pairs from the Scandinavian population-based prospective PreventADALL cohort with information on birth mode including vaginal birth, either traditional (81.3%) or in water (4.0%), and CS before (6.3%) and after (8.5%) onset of labor. We defined early onset AD as eczema at 3 months and AD diagnosis by 3 years of age. Persistent AD was defined as eczema both in the first year and at 3 years of age, together with an AD diagnosis by 3 years of age. Results: AD was diagnosed at 3, 6, 12, 24, and/or 36 months in 531 children (25%). Compared to vaginal delivery, CS was overall associated with increased odds of AD by 3 years of age, with adjusted odds ratio (95% confidence interval) of 1.33 (1.02-1.74), and higher odds of early onset AD (1.63, 1.06-2.48). The highest odds for early onset AD were observed in infants born by CS after onset of labor (1.83, 1.09-3.07). Birth mode was not associated with persistent AD. Conclusion: CS was associated with increased odds of AD by 3 years of age, particularly in infants presenting with eczema at 3 months of age.http://www.sciencedirect.com/science/article/pii/S2772829323000292Atopic dermatitisearly onset atopic dermatitispersistent atopic dermatitisbirth modecaesarean sectionC-section |
| spellingShingle | Sveinung T. Hoel, MD Johanna Wiik, MD, PhD Karin C.L. Carlsen, MD, PhD Kim M.A. Endre, MD, PhD Hrefna Katrín Gudmundsdóttir, MD Guttorm Haugen, MD, PhD Angela Hoyer, MSc Christine Monceyron Jonassen, PhD Marissa LeBlanc, MSc, PhD Björn Nordlund, RN, PhD Knut Rudi, PhD Håvard O. Skjerven, MD, PhD Anne Cathrine Staff, MD, PhD Gunilla Hedlin, MD, PhD Cilla Söderhäll, MSc, PhD Riyas Vettukattil, MD, PhD Hilde Aaneland, RN Eva M. Rehbinder, MD, PhD Birth mode is associated with development of atopic dermatitis in infancy and early childhood Journal of Allergy and Clinical Immunology: Global Atopic dermatitis early onset atopic dermatitis persistent atopic dermatitis birth mode caesarean section C-section |
| title | Birth mode is associated with development of atopic dermatitis in infancy and early childhood |
| title_full | Birth mode is associated with development of atopic dermatitis in infancy and early childhood |
| title_fullStr | Birth mode is associated with development of atopic dermatitis in infancy and early childhood |
| title_full_unstemmed | Birth mode is associated with development of atopic dermatitis in infancy and early childhood |
| title_short | Birth mode is associated with development of atopic dermatitis in infancy and early childhood |
| title_sort | birth mode is associated with development of atopic dermatitis in infancy and early childhood |
| topic | Atopic dermatitis early onset atopic dermatitis persistent atopic dermatitis birth mode caesarean section C-section |
| url | http://www.sciencedirect.com/science/article/pii/S2772829323000292 |
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