Functional Role of Dietary Intervention to Improve the Outcome of COVID-19: A Hypothesis of Work
Background: On the 31 December 2019, the World Health Organization (WHO) was informed of a cluster of cases of pneumonia of unknown origin detected in Wuhan City, Hubei Province, China. The infection spread first in China and then in the rest of the world, and on the 11th of March, the WHO declared...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/9/3104 |
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| author | Giovanni Messina Rita Polito Vincenzo Monda Luigi Cipolloni Nunzio Di Nunno Giulio Di Mizio Paolo Murabito Marco Carotenuto Antonietta Messina Daniela Pisanelli Anna Valenzano Giuseppe Cibelli Alessia Scarinci Marcellino Monda Francesco Sessa |
| author_facet | Giovanni Messina Rita Polito Vincenzo Monda Luigi Cipolloni Nunzio Di Nunno Giulio Di Mizio Paolo Murabito Marco Carotenuto Antonietta Messina Daniela Pisanelli Anna Valenzano Giuseppe Cibelli Alessia Scarinci Marcellino Monda Francesco Sessa |
| author_sort | Giovanni Messina |
| collection | DOAJ |
| description | Background: On the 31 December 2019, the World Health Organization (WHO) was informed of a cluster of cases of pneumonia of unknown origin detected in Wuhan City, Hubei Province, China. The infection spread first in China and then in the rest of the world, and on the 11th of March, the WHO declared that COVID-19 was a pandemic. Taking into consideration the mortality rate of COVID-19, about 5–7%, and the percentage of positive patients admitted to intensive care units being 9–11%, it should be mandatory to consider and take all necessary measures to contain the COVID-19 infection. Moreover, given the recent evidence in different hospitals suggesting IL-6 and TNF-α inhibitor drugs as a possible therapy for COVID-19, we aimed to highlight that a dietary intervention could be useful to prevent the infection and/or to ameliorate the outcomes during therapy. Considering that the COVID-19 infection can generate a mild or highly acute respiratory syndrome with a consequent release of pro-inflammatory cytokines, including IL-6 and TNF-α, a dietary regimen modification in order to improve the levels of adiponectin could be very useful both to prevent the infection and to take care of patients, improving their outcomes. |
| first_indexed | 2024-03-10T20:10:32Z |
| format | Article |
| id | doaj.art-76a7fad6d9c7408d8159e3d74ccd9499 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T20:10:32Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-76a7fad6d9c7408d8159e3d74ccd94992023-11-19T22:56:15ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-04-01219310410.3390/ijms21093104Functional Role of Dietary Intervention to Improve the Outcome of COVID-19: A Hypothesis of WorkGiovanni Messina0Rita Polito1Vincenzo Monda2Luigi Cipolloni3Nunzio Di Nunno4Giulio Di Mizio5Paolo Murabito6Marco Carotenuto7Antonietta Messina8Daniela Pisanelli9Anna Valenzano10Giuseppe Cibelli11Alessia Scarinci12Marcellino Monda13Francesco Sessa14Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, ItalyDepartment of Experimental Medicine, Section of Human Physiology and Unit of Dietetics and Sports Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, ItalyDepartment of History, Society and Studies on Humanity, University of Salento, 73100 Lecce, ItalyDepartment of Law, Forensic Medicine, Magna Graecia University of Catanzaro, 88100 Catanzaro, ItalyDepartment of General Surgery and Medical-Surgical Specialties, University of Catania, 95121 Catania, ItalyDepartment of Mental Health, Physical and Preventive Medicine, Clinic of Child and Adolescent Neuropsychiatry, Università degli Studi della Campania “Luigi Vanvitelli”, 81100 Caserta, ItalyDepartment of Experimental Medicine, Section of Human Physiology and Unit of Dietetics and Sports Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, ItalyDepartment of Education Sciences, Psychology and Communication, University of Bari, 70121 Bari, ItalyDepartment of Experimental Medicine, Section of Human Physiology and Unit of Dietetics and Sports Medicine, Università degli Studi della Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, ItalyBackground: On the 31 December 2019, the World Health Organization (WHO) was informed of a cluster of cases of pneumonia of unknown origin detected in Wuhan City, Hubei Province, China. The infection spread first in China and then in the rest of the world, and on the 11th of March, the WHO declared that COVID-19 was a pandemic. Taking into consideration the mortality rate of COVID-19, about 5–7%, and the percentage of positive patients admitted to intensive care units being 9–11%, it should be mandatory to consider and take all necessary measures to contain the COVID-19 infection. Moreover, given the recent evidence in different hospitals suggesting IL-6 and TNF-α inhibitor drugs as a possible therapy for COVID-19, we aimed to highlight that a dietary intervention could be useful to prevent the infection and/or to ameliorate the outcomes during therapy. Considering that the COVID-19 infection can generate a mild or highly acute respiratory syndrome with a consequent release of pro-inflammatory cytokines, including IL-6 and TNF-α, a dietary regimen modification in order to improve the levels of adiponectin could be very useful both to prevent the infection and to take care of patients, improving their outcomes.https://www.mdpi.com/1422-0067/21/9/3104COVID-19IL-6adiponectinω-3 PUFAslung infectionsdiet therapies |
| spellingShingle | Giovanni Messina Rita Polito Vincenzo Monda Luigi Cipolloni Nunzio Di Nunno Giulio Di Mizio Paolo Murabito Marco Carotenuto Antonietta Messina Daniela Pisanelli Anna Valenzano Giuseppe Cibelli Alessia Scarinci Marcellino Monda Francesco Sessa Functional Role of Dietary Intervention to Improve the Outcome of COVID-19: A Hypothesis of Work International Journal of Molecular Sciences COVID-19 IL-6 adiponectin ω-3 PUFAs lung infections diet therapies |
| title | Functional Role of Dietary Intervention to Improve the Outcome of COVID-19: A Hypothesis of Work |
| title_full | Functional Role of Dietary Intervention to Improve the Outcome of COVID-19: A Hypothesis of Work |
| title_fullStr | Functional Role of Dietary Intervention to Improve the Outcome of COVID-19: A Hypothesis of Work |
| title_full_unstemmed | Functional Role of Dietary Intervention to Improve the Outcome of COVID-19: A Hypothesis of Work |
| title_short | Functional Role of Dietary Intervention to Improve the Outcome of COVID-19: A Hypothesis of Work |
| title_sort | functional role of dietary intervention to improve the outcome of covid 19 a hypothesis of work |
| topic | COVID-19 IL-6 adiponectin ω-3 PUFAs lung infections diet therapies |
| url | https://www.mdpi.com/1422-0067/21/9/3104 |
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