Effects of Maternal Fish Oil and/or 5-Methyl-Tetrahydrofolate Supplementation during Pregnancy on Offspring Brain Resting-State at 10 Years Old: A Follow-Up Study from the NUHEAL Randomized Controlled Trial
Recent studies have shown that maternal supplementation with folate and long-chain polyunsaturated fatty acids (LC-PUFAs) during pregnancy may affect children’s brain development. We aimed at examining the potential long-term effect of maternal supplementation with fish oil (FO) and/or 5-methyl-tetr...
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MDPI AG
2020-09-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/9/2701 |
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| author | Hatim Azaryah Juan Verdejo-Román Cristina Martin-Pérez José Antonio García-Santos Cristina Martínez-Zaldívar Francisco J. Torres-Espínola Daniel Campos Berthold Koletzko Miguel Pérez-García Andrés Catena Cristina Campoy |
| author_facet | Hatim Azaryah Juan Verdejo-Román Cristina Martin-Pérez José Antonio García-Santos Cristina Martínez-Zaldívar Francisco J. Torres-Espínola Daniel Campos Berthold Koletzko Miguel Pérez-García Andrés Catena Cristina Campoy |
| author_sort | Hatim Azaryah |
| collection | DOAJ |
| description | Recent studies have shown that maternal supplementation with folate and long-chain polyunsaturated fatty acids (LC-PUFAs) during pregnancy may affect children’s brain development. We aimed at examining the potential long-term effect of maternal supplementation with fish oil (FO) and/or 5-methyl-tetrahydrofolate (5-MTHF) on the brain functionality of offspring at the age of 9.5–10 years. The current study was conducted as a follow-up of the Spanish participants belonging to the Nutraceuticals for a Healthier Life (NUHEAL) project; 57 children were divided into groups according to mother’s supplementation and assessed through functional magnetic resonance imaging (fMRI) scanning and neurodevelopment testing. Independent component analysis and double regression methods were implemented to investigate plausible associations. Children born to mothers supplemented with FO (FO and FO + 5-MTHF groups, <i>n</i> = 33) showed weaker functional connectivity in the default mode (DM) (angular gyrus), the sensorimotor (SM) (motor and somatosensory cortices) and the fronto-parietal (FP) (angular gyrus) networks compared to the No-FO group (placebo and 5-MTHF groups, <i>n</i> = 24) (P<sub>FWE</sub> < 0.05). Furthermore, no differences were found regarding the neuropsychological tests, except for a trend of better results in an object recall (memory) test. Considering the No-FO group, the aforementioned networks were associated negatively with attention and speed-processing functions. Mother’s FO supplementation during pregnancy seems to be able to shape resting-state network functioning in their children at school age and appears to produce long-term effects on children´s cognitive processing. |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T16:33:59Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-76a874e736734aceaf1ab8fb119bb2992023-11-20T12:34:46ZengMDPI AGNutrients2072-66432020-09-01129270110.3390/nu12092701Effects of Maternal Fish Oil and/or 5-Methyl-Tetrahydrofolate Supplementation during Pregnancy on Offspring Brain Resting-State at 10 Years Old: A Follow-Up Study from the NUHEAL Randomized Controlled TrialHatim Azaryah0Juan Verdejo-Román1Cristina Martin-Pérez2José Antonio García-Santos3Cristina Martínez-Zaldívar4Francisco J. Torres-Espínola5Daniel Campos6Berthold Koletzko7Miguel Pérez-García8Andrés Catena9Cristina Campoy10Department of Paediatrics, School of Medicine, University of Granada, Avda. Investigación 11, 18016 Granada, SpainMind, Brain and Behaviour International Research Centre (CIMCYC), University of Granada, 18011 Granada, SpainMind, Brain and Behaviour International Research Centre (CIMCYC), University of Granada, 18011 Granada, SpainDepartment of Paediatrics, School of Medicine, University of Granada, Avda. Investigación 11, 18016 Granada, SpainDepartment of Paediatrics, School of Medicine, University of Granada, Avda. Investigación 11, 18016 Granada, SpainDepartment of Paediatrics, School of Medicine, University of Granada, Avda. Investigación 11, 18016 Granada, SpainDepartment of Paediatrics, School of Medicine, University of Granada, Avda. Investigación 11, 18016 Granada, SpainLudwig-Maximiliams-Universität München, Dr. von Hauner Children’s Hospital, University of Munich Hospitals, 80337 Munich, GermanyMind, Brain and Behaviour International Research Centre (CIMCYC), University of Granada, 18011 Granada, SpainMind, Brain and Behaviour International Research Centre (CIMCYC), University of Granada, 18011 Granada, SpainDepartment of Paediatrics, School of Medicine, University of Granada, Avda. Investigación 11, 18016 Granada, SpainRecent studies have shown that maternal supplementation with folate and long-chain polyunsaturated fatty acids (LC-PUFAs) during pregnancy may affect children’s brain development. We aimed at examining the potential long-term effect of maternal supplementation with fish oil (FO) and/or 5-methyl-tetrahydrofolate (5-MTHF) on the brain functionality of offspring at the age of 9.5–10 years. The current study was conducted as a follow-up of the Spanish participants belonging to the Nutraceuticals for a Healthier Life (NUHEAL) project; 57 children were divided into groups according to mother’s supplementation and assessed through functional magnetic resonance imaging (fMRI) scanning and neurodevelopment testing. Independent component analysis and double regression methods were implemented to investigate plausible associations. Children born to mothers supplemented with FO (FO and FO + 5-MTHF groups, <i>n</i> = 33) showed weaker functional connectivity in the default mode (DM) (angular gyrus), the sensorimotor (SM) (motor and somatosensory cortices) and the fronto-parietal (FP) (angular gyrus) networks compared to the No-FO group (placebo and 5-MTHF groups, <i>n</i> = 24) (P<sub>FWE</sub> < 0.05). Furthermore, no differences were found regarding the neuropsychological tests, except for a trend of better results in an object recall (memory) test. Considering the No-FO group, the aforementioned networks were associated negatively with attention and speed-processing functions. Mother’s FO supplementation during pregnancy seems to be able to shape resting-state network functioning in their children at school age and appears to produce long-term effects on children´s cognitive processing.https://www.mdpi.com/2072-6643/12/9/2701fish oilfolatepregnancybrain functionresting-state functional neuroimagingneurodevelopment |
| spellingShingle | Hatim Azaryah Juan Verdejo-Román Cristina Martin-Pérez José Antonio García-Santos Cristina Martínez-Zaldívar Francisco J. Torres-Espínola Daniel Campos Berthold Koletzko Miguel Pérez-García Andrés Catena Cristina Campoy Effects of Maternal Fish Oil and/or 5-Methyl-Tetrahydrofolate Supplementation during Pregnancy on Offspring Brain Resting-State at 10 Years Old: A Follow-Up Study from the NUHEAL Randomized Controlled Trial Nutrients fish oil folate pregnancy brain function resting-state functional neuroimaging neurodevelopment |
| title | Effects of Maternal Fish Oil and/or 5-Methyl-Tetrahydrofolate Supplementation during Pregnancy on Offspring Brain Resting-State at 10 Years Old: A Follow-Up Study from the NUHEAL Randomized Controlled Trial |
| title_full | Effects of Maternal Fish Oil and/or 5-Methyl-Tetrahydrofolate Supplementation during Pregnancy on Offspring Brain Resting-State at 10 Years Old: A Follow-Up Study from the NUHEAL Randomized Controlled Trial |
| title_fullStr | Effects of Maternal Fish Oil and/or 5-Methyl-Tetrahydrofolate Supplementation during Pregnancy on Offspring Brain Resting-State at 10 Years Old: A Follow-Up Study from the NUHEAL Randomized Controlled Trial |
| title_full_unstemmed | Effects of Maternal Fish Oil and/or 5-Methyl-Tetrahydrofolate Supplementation during Pregnancy on Offspring Brain Resting-State at 10 Years Old: A Follow-Up Study from the NUHEAL Randomized Controlled Trial |
| title_short | Effects of Maternal Fish Oil and/or 5-Methyl-Tetrahydrofolate Supplementation during Pregnancy on Offspring Brain Resting-State at 10 Years Old: A Follow-Up Study from the NUHEAL Randomized Controlled Trial |
| title_sort | effects of maternal fish oil and or 5 methyl tetrahydrofolate supplementation during pregnancy on offspring brain resting state at 10 years old a follow up study from the nuheal randomized controlled trial |
| topic | fish oil folate pregnancy brain function resting-state functional neuroimaging neurodevelopment |
| url | https://www.mdpi.com/2072-6643/12/9/2701 |
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