Association of Changes in Acute Gastrointestinal Injury Grade with Prognosis in Critically Ill Patients: A Prospective, Single-Center, Observational Study
Ming Zhong,1,* Wen Xu,1,* Yuzhen Qiu,1 Lei Li,1 Hongping Qu,1 Erzhen Chen2 1Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People’s Republic of China; 2Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong U...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2021-02-01
|
| Series: | Journal of Multidisciplinary Healthcare |
| Subjects: | |
| Online Access: | https://www.dovepress.com/association-of-changes-in-acute-gastrointestinal-injury-grade-with-pro-peer-reviewed-article-JMDH |
| _version_ | 1818870608838000640 |
|---|---|
| author | Zhong M Xu W Qiu Y Li L Qu H Chen E |
| author_facet | Zhong M Xu W Qiu Y Li L Qu H Chen E |
| author_sort | Zhong M |
| collection | DOAJ |
| description | Ming Zhong,1,* Wen Xu,1,* Yuzhen Qiu,1 Lei Li,1 Hongping Qu,1 Erzhen Chen2 1Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People’s Republic of China; 2Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hongping QuDepartment of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197. Ruijin No.2 Road, Shanghai 200025, People’s Republic of ChinaEmail hongpingqu0412@hotmail.comErzhen ChenDepartment of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, People’s Republic of ChinaEmail rjchenerzhen@163.comPurpose: To investigate the association between the change of acute gastrointestinal injury (AGI) grade and the outcome in critically ill patients.Methods: This was a prospectively observational study. All patients admitted in the ICU from October 2013 to June 2015, with the duration of ICU > 72 h and age > 18 years, were enrolled in this study. The AGI grade and gastrointestinal symptoms were evaluated during ICU stay following the 2012 ESICM recommendation. The ICU mortality, duration of ICU stay, mechanical ventilation (MV) use, vasoactive drug use, and continuous renal replacement therapy of patients were recorded accordingly.Results: A total of 320 patients were included, and 265 of them were diagnosed with AGI. The overall ICU mortality was 11.88%, while it was 13.58% in patients with AGI. In logistic regression analyses, the decreasing trend of AGI grade was identified as a protective factor for ICU death (odds ratio (OR), 0.484; 95% confidence interval (CI), 0.26– 0.90), while the max AGI grade was a risk factor (OR, 3.464; 95% CI, 2.71– 8.47) for ICU death.Conclusion: The changes of AGI grades in critically ill patients were associated with their clinical outcomes. The ICU-acquired AGI patients associated with longer ICU stay days.Keywords: acute gastrointestinal injury grade, ICU stay, critically ill patient, patient outcome, ICU death |
| first_indexed | 2024-12-19T12:09:44Z |
| format | Article |
| id | doaj.art-76aa0da8f33d492e832e18fbb1f9760c |
| institution | Directory Open Access Journal |
| issn | 1178-2390 |
| language | English |
| last_indexed | 2024-12-19T12:09:44Z |
| publishDate | 2021-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Multidisciplinary Healthcare |
| spelling | doaj.art-76aa0da8f33d492e832e18fbb1f9760c2022-12-21T20:22:13ZengDove Medical PressJournal of Multidisciplinary Healthcare1178-23902021-02-01Volume 1427928661811Association of Changes in Acute Gastrointestinal Injury Grade with Prognosis in Critically Ill Patients: A Prospective, Single-Center, Observational StudyZhong MXu WQiu YLi LQu HChen EMing Zhong,1,* Wen Xu,1,* Yuzhen Qiu,1 Lei Li,1 Hongping Qu,1 Erzhen Chen2 1Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People’s Republic of China; 2Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hongping QuDepartment of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197. Ruijin No.2 Road, Shanghai 200025, People’s Republic of ChinaEmail hongpingqu0412@hotmail.comErzhen ChenDepartment of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, People’s Republic of ChinaEmail rjchenerzhen@163.comPurpose: To investigate the association between the change of acute gastrointestinal injury (AGI) grade and the outcome in critically ill patients.Methods: This was a prospectively observational study. All patients admitted in the ICU from October 2013 to June 2015, with the duration of ICU > 72 h and age > 18 years, were enrolled in this study. The AGI grade and gastrointestinal symptoms were evaluated during ICU stay following the 2012 ESICM recommendation. The ICU mortality, duration of ICU stay, mechanical ventilation (MV) use, vasoactive drug use, and continuous renal replacement therapy of patients were recorded accordingly.Results: A total of 320 patients were included, and 265 of them were diagnosed with AGI. The overall ICU mortality was 11.88%, while it was 13.58% in patients with AGI. In logistic regression analyses, the decreasing trend of AGI grade was identified as a protective factor for ICU death (odds ratio (OR), 0.484; 95% confidence interval (CI), 0.26– 0.90), while the max AGI grade was a risk factor (OR, 3.464; 95% CI, 2.71– 8.47) for ICU death.Conclusion: The changes of AGI grades in critically ill patients were associated with their clinical outcomes. The ICU-acquired AGI patients associated with longer ICU stay days.Keywords: acute gastrointestinal injury grade, ICU stay, critically ill patient, patient outcome, ICU deathhttps://www.dovepress.com/association-of-changes-in-acute-gastrointestinal-injury-grade-with-pro-peer-reviewed-article-JMDHacute gastrointestinal injury gradeicu staycritically ill patientpatient outcomeicu death. |
| spellingShingle | Zhong M Xu W Qiu Y Li L Qu H Chen E Association of Changes in Acute Gastrointestinal Injury Grade with Prognosis in Critically Ill Patients: A Prospective, Single-Center, Observational Study Journal of Multidisciplinary Healthcare acute gastrointestinal injury grade icu stay critically ill patient patient outcome icu death. |
| title | Association of Changes in Acute Gastrointestinal Injury Grade with Prognosis in Critically Ill Patients: A Prospective, Single-Center, Observational Study |
| title_full | Association of Changes in Acute Gastrointestinal Injury Grade with Prognosis in Critically Ill Patients: A Prospective, Single-Center, Observational Study |
| title_fullStr | Association of Changes in Acute Gastrointestinal Injury Grade with Prognosis in Critically Ill Patients: A Prospective, Single-Center, Observational Study |
| title_full_unstemmed | Association of Changes in Acute Gastrointestinal Injury Grade with Prognosis in Critically Ill Patients: A Prospective, Single-Center, Observational Study |
| title_short | Association of Changes in Acute Gastrointestinal Injury Grade with Prognosis in Critically Ill Patients: A Prospective, Single-Center, Observational Study |
| title_sort | association of changes in acute gastrointestinal injury grade with prognosis in critically ill patients a prospective single center observational study |
| topic | acute gastrointestinal injury grade icu stay critically ill patient patient outcome icu death. |
| url | https://www.dovepress.com/association-of-changes-in-acute-gastrointestinal-injury-grade-with-pro-peer-reviewed-article-JMDH |
| work_keys_str_mv | AT zhongm associationofchangesinacutegastrointestinalinjurygradewithprognosisincriticallyillpatientsaprospectivesinglecenterobservationalstudy AT xuw associationofchangesinacutegastrointestinalinjurygradewithprognosisincriticallyillpatientsaprospectivesinglecenterobservationalstudy AT qiuy associationofchangesinacutegastrointestinalinjurygradewithprognosisincriticallyillpatientsaprospectivesinglecenterobservationalstudy AT lil associationofchangesinacutegastrointestinalinjurygradewithprognosisincriticallyillpatientsaprospectivesinglecenterobservationalstudy AT quh associationofchangesinacutegastrointestinalinjurygradewithprognosisincriticallyillpatientsaprospectivesinglecenterobservationalstudy AT chene associationofchangesinacutegastrointestinalinjurygradewithprognosisincriticallyillpatientsaprospectivesinglecenterobservationalstudy |