Conservative treatments for feline fibroadenomatous changes of the mammary gland
Background: Fibroadenomatous changes (FAC) of the mammary gland in cats represents a benign, progesterone-associated fibroglandular proliferation of one or more mammary glands that may occur in intact female cats at the time of puberty, during pregnancy or pseudopregnancy, or in female and male cats...
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| Format: | Article |
| Language: | English |
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Tripoli University
2021-11-01
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| Series: | Open Veterinary Journal |
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| Online Access: | https://www.openveterinaryjournal.com/OVJ-2021-07-133%20G.%20Marino%20et%20al.pdf |
| _version_ | 1818344583838302208 |
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| author | Gabriele Marino Michela Pugliese Fabiana Pecchia Giuseppe Garufi Vincenzo Lupo Stefania Di Giorgio Alessandra Sfacteria |
| author_facet | Gabriele Marino Michela Pugliese Fabiana Pecchia Giuseppe Garufi Vincenzo Lupo Stefania Di Giorgio Alessandra Sfacteria |
| author_sort | Gabriele Marino |
| collection | DOAJ |
| description | Background: Fibroadenomatous changes (FAC) of the mammary gland in cats represents a benign, progesterone-associated fibroglandular proliferation of one or more mammary glands that may occur in intact female cats at the time of puberty, during pregnancy or pseudopregnancy, or in female and male cats of any age under progestin treatment. Nowadays, the elective treatment of FAC is based on the progesterone antagonist aglepristone. This study aimed to report the treatment of FAC with a combination of drugs designed to preserve mammary gland integrity, even in pregnant cats.
Case Description: Eight sexually intact female cats with fibroadenomatous changes showed mammary glands that were symmetrically enlarged and inflamed in all cases, and the skin was ulcerated in six cats. Four cats were on days 25-32 of pregnancy at presentation. Non-pregnant cats were treated with aglepristone and with a dietary supplement containing maltodextrin and bromelain. The mammary glands were massaged daily with an Aloe vera emollient gel. If the gland was inflamed or ulcerated, broad-spectrum antimicrobial and anti-inflammatory treatments were given, and the ulcers were treated topically with a hypericum and neem-based cream. Two of the four pregnant cats were treated with the same therapeutic schedule plus cloprostenol to facilitate uterine emptying. Two pregnant cats underwent the same protocol except for aglepristone, which was not administered to safeguard the litter and see if the adjuvant therapy worked independently. At term, they delivered four and three kittens respectively, that were normally nursed and weaned after 40 days. In all the studied cases, the mammary gland reduced in size 2-3 weeks after the start of the treatment and completely remitted after 4-5 weeks.
Conclusion: This case series encourages adjuvant therapy in the course of FAC to preserve mammary gland integrity and functionality. Exploiting the natural decline of progesterone at the end of pregnancy (or pseudopregnancy), the therapy may also be used without aglepristone, when its use has other limitations. |
| first_indexed | 2024-12-13T16:48:47Z |
| format | Article |
| id | doaj.art-76aa6af2ec6a48c2bac0cb8f48ab1ad4 |
| institution | Directory Open Access Journal |
| issn | 2226-4485 2218-6050 |
| language | English |
| last_indexed | 2024-12-13T16:48:47Z |
| publishDate | 2021-11-01 |
| publisher | Tripoli University |
| record_format | Article |
| series | Open Veterinary Journal |
| spelling | doaj.art-76aa6af2ec6a48c2bac0cb8f48ab1ad42022-12-21T23:38:06ZengTripoli UniversityOpen Veterinary Journal2226-44852218-60502021-11-0111468068510.5455/OVJ.2021.v11.i4.19Conservative treatments for feline fibroadenomatous changes of the mammary glandGabriele Marino0Michela Pugliese1Fabiana Pecchia2Giuseppe Garufi3Vincenzo Lupo4Stefania Di Giorgio5Alessandra Sfacteria6Department of Veterinary Sciences, University of Messina, Viale Giovanni Palatucci, Polo Universitario SS Annunziata, 98168 Messina, ItalyDepartment of Veterinary Sciences, University of Messina, Viale Giovanni Palatucci, Polo Universitario SS Annunziata, 98168 Messina, ItalyDepartment of Veterinary Sciences, University of Messina, Viale Giovanni Palatucci, Polo Universitario SS Annunziata, 98168 Messina, Italy and Polivet, Via Salaria n. 1317, 00138 Rome, ItalyAmbulatorio tre fontane, I° Tronco, Via Reggio Campi n. 78, 89126 Reggio Calabria, ItalyDepartment of Veterinary Sciences, University of Messina, Viale Giovanni Palatucci, Polo Universitario SS Annunziata, 98168 Messina, Italy and Almavet, Via Giovanni Leone n. 50, 91021 Campobello di Mazara, Trapani, ItalyDepartment of Veterinary Sciences, University of Messina, Viale Giovanni Palatucci, Polo Universitario SS Annunziata, 98168 Messina, ItalyDepartment of Veterinary Sciences, University of Messina, Viale Giovanni Palatucci, Polo Universitario SS Annunziata, 98168 Messina, ItalyBackground: Fibroadenomatous changes (FAC) of the mammary gland in cats represents a benign, progesterone-associated fibroglandular proliferation of one or more mammary glands that may occur in intact female cats at the time of puberty, during pregnancy or pseudopregnancy, or in female and male cats of any age under progestin treatment. Nowadays, the elective treatment of FAC is based on the progesterone antagonist aglepristone. This study aimed to report the treatment of FAC with a combination of drugs designed to preserve mammary gland integrity, even in pregnant cats. Case Description: Eight sexually intact female cats with fibroadenomatous changes showed mammary glands that were symmetrically enlarged and inflamed in all cases, and the skin was ulcerated in six cats. Four cats were on days 25-32 of pregnancy at presentation. Non-pregnant cats were treated with aglepristone and with a dietary supplement containing maltodextrin and bromelain. The mammary glands were massaged daily with an Aloe vera emollient gel. If the gland was inflamed or ulcerated, broad-spectrum antimicrobial and anti-inflammatory treatments were given, and the ulcers were treated topically with a hypericum and neem-based cream. Two of the four pregnant cats were treated with the same therapeutic schedule plus cloprostenol to facilitate uterine emptying. Two pregnant cats underwent the same protocol except for aglepristone, which was not administered to safeguard the litter and see if the adjuvant therapy worked independently. At term, they delivered four and three kittens respectively, that were normally nursed and weaned after 40 days. In all the studied cases, the mammary gland reduced in size 2-3 weeks after the start of the treatment and completely remitted after 4-5 weeks. Conclusion: This case series encourages adjuvant therapy in the course of FAC to preserve mammary gland integrity and functionality. Exploiting the natural decline of progesterone at the end of pregnancy (or pseudopregnancy), the therapy may also be used without aglepristone, when its use has other limitations.https://www.openveterinaryjournal.com/OVJ-2021-07-133%20G.%20Marino%20et%20al.pdfcattumoraglepristonehypericumaloe |
| spellingShingle | Gabriele Marino Michela Pugliese Fabiana Pecchia Giuseppe Garufi Vincenzo Lupo Stefania Di Giorgio Alessandra Sfacteria Conservative treatments for feline fibroadenomatous changes of the mammary gland Open Veterinary Journal cat tumor aglepristone hypericum aloe |
| title | Conservative treatments for feline fibroadenomatous changes of the mammary gland |
| title_full | Conservative treatments for feline fibroadenomatous changes of the mammary gland |
| title_fullStr | Conservative treatments for feline fibroadenomatous changes of the mammary gland |
| title_full_unstemmed | Conservative treatments for feline fibroadenomatous changes of the mammary gland |
| title_short | Conservative treatments for feline fibroadenomatous changes of the mammary gland |
| title_sort | conservative treatments for feline fibroadenomatous changes of the mammary gland |
| topic | cat tumor aglepristone hypericum aloe |
| url | https://www.openveterinaryjournal.com/OVJ-2021-07-133%20G.%20Marino%20et%20al.pdf |
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