Relationship between 25-hydroxy vitamin D and knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials
ObjectiveIn order to examine the relationship between 25-hydroxyl vitamin D and knee osteoarthritis (KOA), a meta-analysis of 8 randomized controlled trials (RCTs) publications was hereby performed.MethodsFor the purpose of finding pertinent research, the databases of PubMed, Embase and the Cochrane...
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1200592/full |
| _version_ | 1797756509570990080 |
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| author | Rui Wang Rui Wang Zheng-ming Wang Si-cheng Xiang Zhao-kai Jin Jing-jing Zhang Ji-cheng Zeng Pei-jian Tong Shuai-jie Lv |
| author_facet | Rui Wang Rui Wang Zheng-ming Wang Si-cheng Xiang Zhao-kai Jin Jing-jing Zhang Ji-cheng Zeng Pei-jian Tong Shuai-jie Lv |
| author_sort | Rui Wang |
| collection | DOAJ |
| description | ObjectiveIn order to examine the relationship between 25-hydroxyl vitamin D and knee osteoarthritis (KOA), a meta-analysis of 8 randomized controlled trials (RCTs) publications was hereby performed.MethodsFor the purpose of finding pertinent research, the databases of PubMed, Embase and the Cochrane Library were searched. Factors including tibial cartilage volume, joint space width (JSW), synovial fluid volume, and Western Ontario and McMaster Universities Arthritis Index (WOMAC) were correspondingly evaluated, and the results were expressed using SMD and 95% confidence intervals (CI).ResultsThe present meta-analysis evaluated the effects of vitamin D supplementation in patients with knee osteoarthritis, with 3,077 patients included. The results showed that vitamin D administration had a statistically significant impact on the amount of synovial fluid, Visual Analog Scale (VAS) and tibial cartilage. The pain and function scales of the WOMAC scale presented a statistically significant difference, and there was no discernible difference between the vitamin D and placebo groups in the stiffness scale. Additionally, bone marrow lesions and alterations in the diameter of the joint space were not influenced by the administration of vitamin D, and according to a subgroup study, a daily vitamin D supplement containing more than 2,000 IU significantly slowed the development of synovial tissue.ConclusionVitamin D supplementation did benefit those suffering from knee discomfort and knee dysfunction.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022332033, identifier: CRD42022332033. |
| first_indexed | 2024-03-12T18:01:29Z |
| format | Article |
| id | doaj.art-76aade0fd37b4f8b927a55e7c68b7306 |
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| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-12T18:01:29Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-76aade0fd37b4f8b927a55e7c68b73062023-08-02T09:40:52ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-08-011010.3389/fmed.2023.12005921200592Relationship between 25-hydroxy vitamin D and knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trialsRui Wang0Rui Wang1Zheng-ming Wang2Si-cheng Xiang3Zhao-kai Jin4Jing-jing Zhang5Ji-cheng Zeng6Pei-jian Tong7Shuai-jie Lv8Guanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Orthopedic Surgery, Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, ChinaShi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaThe First Clinical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaThe First Clinical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaThe First Clinical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaThe First Clinical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaThe First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, ChinaThe First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, ChinaObjectiveIn order to examine the relationship between 25-hydroxyl vitamin D and knee osteoarthritis (KOA), a meta-analysis of 8 randomized controlled trials (RCTs) publications was hereby performed.MethodsFor the purpose of finding pertinent research, the databases of PubMed, Embase and the Cochrane Library were searched. Factors including tibial cartilage volume, joint space width (JSW), synovial fluid volume, and Western Ontario and McMaster Universities Arthritis Index (WOMAC) were correspondingly evaluated, and the results were expressed using SMD and 95% confidence intervals (CI).ResultsThe present meta-analysis evaluated the effects of vitamin D supplementation in patients with knee osteoarthritis, with 3,077 patients included. The results showed that vitamin D administration had a statistically significant impact on the amount of synovial fluid, Visual Analog Scale (VAS) and tibial cartilage. The pain and function scales of the WOMAC scale presented a statistically significant difference, and there was no discernible difference between the vitamin D and placebo groups in the stiffness scale. Additionally, bone marrow lesions and alterations in the diameter of the joint space were not influenced by the administration of vitamin D, and according to a subgroup study, a daily vitamin D supplement containing more than 2,000 IU significantly slowed the development of synovial tissue.ConclusionVitamin D supplementation did benefit those suffering from knee discomfort and knee dysfunction.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022332033, identifier: CRD42022332033.https://www.frontiersin.org/articles/10.3389/fmed.2023.1200592/full25-hydroxyvitamin Dvitamin Drandomized controlled trialmeta-analysisknee osteoarthritis |
| spellingShingle | Rui Wang Rui Wang Zheng-ming Wang Si-cheng Xiang Zhao-kai Jin Jing-jing Zhang Ji-cheng Zeng Pei-jian Tong Shuai-jie Lv Relationship between 25-hydroxy vitamin D and knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials Frontiers in Medicine 25-hydroxyvitamin D vitamin D randomized controlled trial meta-analysis knee osteoarthritis |
| title | Relationship between 25-hydroxy vitamin D and knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials |
| title_full | Relationship between 25-hydroxy vitamin D and knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials |
| title_fullStr | Relationship between 25-hydroxy vitamin D and knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials |
| title_full_unstemmed | Relationship between 25-hydroxy vitamin D and knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials |
| title_short | Relationship between 25-hydroxy vitamin D and knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials |
| title_sort | relationship between 25 hydroxy vitamin d and knee osteoarthritis a systematic review and meta analysis of randomized controlled trials |
| topic | 25-hydroxyvitamin D vitamin D randomized controlled trial meta-analysis knee osteoarthritis |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1200592/full |
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