microRNA-27a-3p delivered by extracellular vesicles from glioblastoma cells induces M2 macrophage polarization via the EZH1/KDM3A/CTGF axis

microRNA-27a-3p delivered by extracellular vesicles from glioblastoma cells induces M2 macrophage polarization via the EZH1/KDM3A/CTGF axis

Abstract Glioblastoma (GBM) cell-derived extracellular vesicles (EVs) have been demonstrated to modulate tumor microenvironment. In the present study, we attempted to discuss the role of hsa-microRNA-27a-3p (miR-27a-3p) delivered by GBM-EVs in M2 macrophage polarization. The isolated GBM-EVs were co...

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Bibliographic Details
Main Authors: Guifang Zhao, Hongquan Yu, Lijuan Ding, Weiyao Wang, Huan Wang, Yao Hu, Lingsha Qin, Guangce Deng, Buqing Xie, Guofeng Li, Ling Qi
Format: Article
Language:English
Published: Nature Publishing Group 2022-05-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-022-01035-z

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