(S)-Thienyl and (R)-Pirydyl phosphonate Derivatives Synthesized by Stereoselective Resolution of Their Racemic Mixtures With Rhodotorula mucilaginosa (DSM 70403) - Scaling Approaches

(S)-Thienyl and (R)-Pirydyl phosphonate Derivatives Synthesized by Stereoselective Resolution of Their Racemic Mixtures With Rhodotorula mucilaginosa (DSM 70403) - Scaling Approaches

Rhodotorula mucilaginosa was successfully applied as a biocatalyst for the enantioselective resolution of the racemic mixtures of heteroatom phosphonates derivatives, resulting in receiving the following enantiomers: (S)-1-amino-1(2-thienyl)methylphosphonic acid (Product 1) and (R)-1-amino-1-(3′piry...

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Main Authors: Katarzyna Lubiak-Kozłowska, Małgorzata Brzezińska-Rodak, Magdalena Klimek-Ochab, Tomasz K. Olszewski, Monika Serafin-Lewańczuk, Ewa Żymańczyk-Duda
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Chemistry
Subjects:
Rhodotorula mucilaginosa
biocatalysis
heterocyclic phosphonates
stereoselectivity
pure enantiomers
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2020.589720/full

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