EEG Correlates of Active Stopping and Preparation for Stopping in Chronic Tic Disorder
Motor inhibition is an important cognitive process involved in tic suppression. As the right frontal lobe contains important inhibitory network nodes, we characterized right superior, middle, and inferior frontal gyral (RSFG, RMFG, RIFG) event-related oscillations during motor inhibition in youth wi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/12/2/151 |
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| author | Alonso Zea Vera Ernest V. Pedapati Travis R. Larsh Kevin Kohmescher Makoto Miyakoshi David A. Huddleston Hannah S. Jackson Donald L. Gilbert Paul S. Horn Steve W. Wu |
| author_facet | Alonso Zea Vera Ernest V. Pedapati Travis R. Larsh Kevin Kohmescher Makoto Miyakoshi David A. Huddleston Hannah S. Jackson Donald L. Gilbert Paul S. Horn Steve W. Wu |
| author_sort | Alonso Zea Vera |
| collection | DOAJ |
| description | Motor inhibition is an important cognitive process involved in tic suppression. As the right frontal lobe contains important inhibitory network nodes, we characterized right superior, middle, and inferior frontal gyral (RSFG, RMFG, RIFG) event-related oscillations during motor inhibition in youth with chronic tic disorders (CTD) versus controls. Fourteen children with CTD and 13 controls (10–17 years old) completed an anticipated-response stop signal task while dense-array electroencephalography was recorded. Between-group differences in spectral power changes (3–50 Hz) were explored after source localization and multiple comparisons correction. Two epochs within the stop signal task were studied: (1) preparatory phase early in the trial before motor execution/inhibition and (2) active inhibition phase after stop signal presentation. Correlation analyses between electrophysiologic data and clinical rating scales for tic, obsessive-compulsive symptoms, and inattention/hyperactivity were performed. There were no behavioral or electrophysiological differences during active stopping. During stop preparation, CTD participants showed greater event-related desynchronization (ERD) in the RSFG (γ-band), RMFG (β, γ-bands), and RIFG (θ, α, β, γ-bands). Higher RSFG γ-ERD correlated with lower tic severity (r = 0.66, <i>p</i> = 0.04). Our findings suggest RSFG γ-ERD may represent a mechanism that allows CTD patients to keep tics under control and achieve behavioral performance similar to peers. |
| first_indexed | 2024-03-09T22:28:01Z |
| format | Article |
| id | doaj.art-76accd6bf52a486abe922febb4721252 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T22:28:01Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-76accd6bf52a486abe922febb47212522023-11-23T19:02:22ZengMDPI AGBrain Sciences2076-34252022-01-0112215110.3390/brainsci12020151EEG Correlates of Active Stopping and Preparation for Stopping in Chronic Tic DisorderAlonso Zea Vera0Ernest V. Pedapati1Travis R. Larsh2Kevin Kohmescher3Makoto Miyakoshi4David A. Huddleston5Hannah S. Jackson6Donald L. Gilbert7Paul S. Horn8Steve W. Wu9Department of Neurology, Children’s National Hospital, Washington, DC 20010, USADivision of Child and Adolescent Psychiatry, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADivision of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USACollege of Engineering and Applied Science, University of Cincinnati, Cincinnati, OH 45267, USASwartz Center for Computational Neuroscience, Institute for Neural Computation, University of California San Diego, La Jolla, CA 92093, USADivision of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADivision of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADivision of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADivision of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USADivision of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USAMotor inhibition is an important cognitive process involved in tic suppression. As the right frontal lobe contains important inhibitory network nodes, we characterized right superior, middle, and inferior frontal gyral (RSFG, RMFG, RIFG) event-related oscillations during motor inhibition in youth with chronic tic disorders (CTD) versus controls. Fourteen children with CTD and 13 controls (10–17 years old) completed an anticipated-response stop signal task while dense-array electroencephalography was recorded. Between-group differences in spectral power changes (3–50 Hz) were explored after source localization and multiple comparisons correction. Two epochs within the stop signal task were studied: (1) preparatory phase early in the trial before motor execution/inhibition and (2) active inhibition phase after stop signal presentation. Correlation analyses between electrophysiologic data and clinical rating scales for tic, obsessive-compulsive symptoms, and inattention/hyperactivity were performed. There were no behavioral or electrophysiological differences during active stopping. During stop preparation, CTD participants showed greater event-related desynchronization (ERD) in the RSFG (γ-band), RMFG (β, γ-bands), and RIFG (θ, α, β, γ-bands). Higher RSFG γ-ERD correlated with lower tic severity (r = 0.66, <i>p</i> = 0.04). Our findings suggest RSFG γ-ERD may represent a mechanism that allows CTD patients to keep tics under control and achieve behavioral performance similar to peers.https://www.mdpi.com/2076-3425/12/2/151Tourette Syndromeelectroencephalographystop signal task |
| spellingShingle | Alonso Zea Vera Ernest V. Pedapati Travis R. Larsh Kevin Kohmescher Makoto Miyakoshi David A. Huddleston Hannah S. Jackson Donald L. Gilbert Paul S. Horn Steve W. Wu EEG Correlates of Active Stopping and Preparation for Stopping in Chronic Tic Disorder Brain Sciences Tourette Syndrome electroencephalography stop signal task |
| title | EEG Correlates of Active Stopping and Preparation for Stopping in Chronic Tic Disorder |
| title_full | EEG Correlates of Active Stopping and Preparation for Stopping in Chronic Tic Disorder |
| title_fullStr | EEG Correlates of Active Stopping and Preparation for Stopping in Chronic Tic Disorder |
| title_full_unstemmed | EEG Correlates of Active Stopping and Preparation for Stopping in Chronic Tic Disorder |
| title_short | EEG Correlates of Active Stopping and Preparation for Stopping in Chronic Tic Disorder |
| title_sort | eeg correlates of active stopping and preparation for stopping in chronic tic disorder |
| topic | Tourette Syndrome electroencephalography stop signal task |
| url | https://www.mdpi.com/2076-3425/12/2/151 |
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