Effectiveness of an Electronic Automated Antibiotic Time Out Alert in the Setting of Gram-Negative Bacteremia
To minimize complications associated with over-utilization of antibiotics, many antimicrobial stewardship programs have incorporated an antibiotic time out (ATO); however, limited data are available to support its effectiveness. This was a single-center retrospective cohort study assessing the impac...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/10/9/1078 |
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| author | Sana M. Mohayya Navaneeth Narayanan Daniel Cimilluca Alexander Malanowski Parth Vaidya Tanaya Bhowmick |
| author_facet | Sana M. Mohayya Navaneeth Narayanan Daniel Cimilluca Alexander Malanowski Parth Vaidya Tanaya Bhowmick |
| author_sort | Sana M. Mohayya |
| collection | DOAJ |
| description | To minimize complications associated with over-utilization of antibiotics, many antimicrobial stewardship programs have incorporated an antibiotic time out (ATO); however, limited data are available to support its effectiveness. This was a single-center retrospective cohort study assessing the impact of the automated electronic ATO in the setting of Gram-negative bacteremia. The primary outcome was the proportion of patients who received a modification of therapy within 24 h of final culture results. Secondary outcomes included modification at any point in therapy, time to modification of therapy, time to de-escalation, and days of therapy of broad-spectrum antibiotics. There was a total of 222 patients who met inclusion criteria, 97 patients pre-ATO and 125 patients post-ATO. The primary outcome of modification of therapy within 24 h of final culture results was not significantly different (24% vs. 30%, <i>p</i> = 0.33). The secondary outcome of modification of therapy at any point in therapy was not significantly different between the two groups (65% vs. 67%, <i>p</i> = 0.73). All other secondary outcomes were not significantly different. The ATO alert was not associated with a higher rate of antibiotic modification within 24 h of culture results in patients with GNB. Further efforts are needed to optimize the ATO strategy and antibiotic prescribing practices. |
| first_indexed | 2024-03-10T07:57:08Z |
| format | Article |
| id | doaj.art-76ad0c0fc78b46d99316e7f7b0086d2a |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T07:57:08Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-76ad0c0fc78b46d99316e7f7b0086d2a2023-11-22T11:45:54ZengMDPI AGAntibiotics2079-63822021-09-01109107810.3390/antibiotics10091078Effectiveness of an Electronic Automated Antibiotic Time Out Alert in the Setting of Gram-Negative BacteremiaSana M. Mohayya0Navaneeth Narayanan1Daniel Cimilluca2Alexander Malanowski3Parth Vaidya4Tanaya Bhowmick5Department of Pharmacy, Robert Wood Johnson University Hospital, New Brunswick, NJ 08901, USADepartment of Pharmacy, Robert Wood Johnson University Hospital, New Brunswick, NJ 08901, USADepartment of Pathology and Laboratory Medicine, Robert Wood Johnson University Hospital, New Brunswick, NJ 08901, USADepartment of Medicine, Division of Allergy, Immunology, Infectious Diseases, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USADepartment of Pharmacy Practice and Administration, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USADepartment of Medicine, Division of Allergy, Immunology, Infectious Diseases, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USATo minimize complications associated with over-utilization of antibiotics, many antimicrobial stewardship programs have incorporated an antibiotic time out (ATO); however, limited data are available to support its effectiveness. This was a single-center retrospective cohort study assessing the impact of the automated electronic ATO in the setting of Gram-negative bacteremia. The primary outcome was the proportion of patients who received a modification of therapy within 24 h of final culture results. Secondary outcomes included modification at any point in therapy, time to modification of therapy, time to de-escalation, and days of therapy of broad-spectrum antibiotics. There was a total of 222 patients who met inclusion criteria, 97 patients pre-ATO and 125 patients post-ATO. The primary outcome of modification of therapy within 24 h of final culture results was not significantly different (24% vs. 30%, <i>p</i> = 0.33). The secondary outcome of modification of therapy at any point in therapy was not significantly different between the two groups (65% vs. 67%, <i>p</i> = 0.73). All other secondary outcomes were not significantly different. The ATO alert was not associated with a higher rate of antibiotic modification within 24 h of culture results in patients with GNB. Further efforts are needed to optimize the ATO strategy and antibiotic prescribing practices.https://www.mdpi.com/2079-6382/10/9/1078antimicrobial stewardshipantibioticsantimicrobial prescribingbehavior change |
| spellingShingle | Sana M. Mohayya Navaneeth Narayanan Daniel Cimilluca Alexander Malanowski Parth Vaidya Tanaya Bhowmick Effectiveness of an Electronic Automated Antibiotic Time Out Alert in the Setting of Gram-Negative Bacteremia Antibiotics antimicrobial stewardship antibiotics antimicrobial prescribing behavior change |
| title | Effectiveness of an Electronic Automated Antibiotic Time Out Alert in the Setting of Gram-Negative Bacteremia |
| title_full | Effectiveness of an Electronic Automated Antibiotic Time Out Alert in the Setting of Gram-Negative Bacteremia |
| title_fullStr | Effectiveness of an Electronic Automated Antibiotic Time Out Alert in the Setting of Gram-Negative Bacteremia |
| title_full_unstemmed | Effectiveness of an Electronic Automated Antibiotic Time Out Alert in the Setting of Gram-Negative Bacteremia |
| title_short | Effectiveness of an Electronic Automated Antibiotic Time Out Alert in the Setting of Gram-Negative Bacteremia |
| title_sort | effectiveness of an electronic automated antibiotic time out alert in the setting of gram negative bacteremia |
| topic | antimicrobial stewardship antibiotics antimicrobial prescribing behavior change |
| url | https://www.mdpi.com/2079-6382/10/9/1078 |
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