Gradual hypertension induction in middle‐aged Cyp1a1‐Ren2 transgenic rats produces significant impairments in spatial learning

Gradual hypertension induction in middle‐aged Cyp1a1‐Ren2 transgenic rats produces significant impairments in spatial learning

Abstract Hypertension is a major health concern in the developed world, and its prevalence increases with advancing age. The impact of hypertension on the function of the renal and cardiovascular systems is well studied; however, its influence on the brain regions important for cognition has garnere...

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Bibliographic Details
Main Authors: Mari N. Willeman, Monica K. Chawla, Marc A. Zempare, Lauren A Biwer, Lan T. Hoang, Ajay R. Uprety, Megan C. Fitzhugh, Matthew De Both, Paul D. Coleman, Theodore P. Trouard, Gene E. Alexander, Kenneth D. Mitchell, Carol A. Barnes, Taben M. Hale, Matthew Huentelman
Format: Article
Language:English
Published: Wiley 2019-03-01
Series:Physiological Reports
Subjects:
Cognition
end organ damage
hypertension
renin angiotensin system
Online Access:https://doi.org/10.14814/phy2.14010

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