New Cytotoxic Cytochalasans from a Plant-Associated Fungus <i>Chaetomium globosum</i> kz-19
Four new cytochalasans, phychaetoglobins A–D (<b>1</b>–<b>4</b>), together with twelve known cytochalasans (<b>5</b>–<b>16</b>), were isolated from a mangrove-associated fungus <i>Chaetomium globosum</i> kz-19. The new structures were eluci...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/19/8/438 |
| _version_ | 1827684865467744256 |
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| author | Tantan Li Yun Wang Li Li Mengyue Tang Qinghong Meng Cun Zhang Erbing Hua Yuehu Pei Yi Sun |
| author_facet | Tantan Li Yun Wang Li Li Mengyue Tang Qinghong Meng Cun Zhang Erbing Hua Yuehu Pei Yi Sun |
| author_sort | Tantan Li |
| collection | DOAJ |
| description | Four new cytochalasans, phychaetoglobins A–D (<b>1</b>–<b>4</b>), together with twelve known cytochalasans (<b>5</b>–<b>16</b>), were isolated from a mangrove-associated fungus <i>Chaetomium globosum</i> kz-19. The new structures were elucidated on the basis of extensive 1D and 2D NMR, HR ESIMS spectroscopic analyses, and electronic circular dichroism (ECD) calculations. The absolute configuration of <b>2</b> was established by application of Mosher’s method. Compounds <b>4</b>–<b>8</b> exhibited moderate cytotoxicities against A549 and HeLa cell lines with the IC<sub>50</sub> values less than 20 μM. |
| first_indexed | 2024-03-10T08:39:08Z |
| format | Article |
| id | doaj.art-76ae263a6afe46a6b348c9019503dc09 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-10T08:39:08Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-76ae263a6afe46a6b348c9019503dc092023-11-22T08:25:41ZengMDPI AGMarine Drugs1660-33972021-07-0119843810.3390/md19080438New Cytotoxic Cytochalasans from a Plant-Associated Fungus <i>Chaetomium globosum</i> kz-19Tantan Li0Yun Wang1Li Li2Mengyue Tang3Qinghong Meng4Cun Zhang5Erbing Hua6Yuehu Pei7Yi Sun8Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaInstitute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaCollege of Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, ChinaSchool of Pharmacy, Harbin Medical University, Harbin 150081, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaFour new cytochalasans, phychaetoglobins A–D (<b>1</b>–<b>4</b>), together with twelve known cytochalasans (<b>5</b>–<b>16</b>), were isolated from a mangrove-associated fungus <i>Chaetomium globosum</i> kz-19. The new structures were elucidated on the basis of extensive 1D and 2D NMR, HR ESIMS spectroscopic analyses, and electronic circular dichroism (ECD) calculations. The absolute configuration of <b>2</b> was established by application of Mosher’s method. Compounds <b>4</b>–<b>8</b> exhibited moderate cytotoxicities against A549 and HeLa cell lines with the IC<sub>50</sub> values less than 20 μM.https://www.mdpi.com/1660-3397/19/8/438<i>Chaetomium globosum</i> kz-19endophytic funguscytochalasanscytotoxicity |
| spellingShingle | Tantan Li Yun Wang Li Li Mengyue Tang Qinghong Meng Cun Zhang Erbing Hua Yuehu Pei Yi Sun New Cytotoxic Cytochalasans from a Plant-Associated Fungus <i>Chaetomium globosum</i> kz-19 Marine Drugs <i>Chaetomium globosum</i> kz-19 endophytic fungus cytochalasans cytotoxicity |
| title | New Cytotoxic Cytochalasans from a Plant-Associated Fungus <i>Chaetomium globosum</i> kz-19 |
| title_full | New Cytotoxic Cytochalasans from a Plant-Associated Fungus <i>Chaetomium globosum</i> kz-19 |
| title_fullStr | New Cytotoxic Cytochalasans from a Plant-Associated Fungus <i>Chaetomium globosum</i> kz-19 |
| title_full_unstemmed | New Cytotoxic Cytochalasans from a Plant-Associated Fungus <i>Chaetomium globosum</i> kz-19 |
| title_short | New Cytotoxic Cytochalasans from a Plant-Associated Fungus <i>Chaetomium globosum</i> kz-19 |
| title_sort | new cytotoxic cytochalasans from a plant associated fungus i chaetomium globosum i kz 19 |
| topic | <i>Chaetomium globosum</i> kz-19 endophytic fungus cytochalasans cytotoxicity |
| url | https://www.mdpi.com/1660-3397/19/8/438 |
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