Psychological Profile and Distinct Salivary Cortisol Awake Response (CAR) in Two Different Study Populations with Obstructive Sleep Apnea (OSA) and Central Serous Chorioretinopathy (CSC)
Obstructive sleep apnea (OSA) and central serous chorioretinopathy (CSC) are in terms of nosography different pathologies, however they share a stress-related physio-pathogenetic component, not yet explored in depth. Therefore, the aim of the present study was to ascertain whether OSA and CSC share...
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MDPI AG
2020-08-01
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| Series: | Journal of Clinical Medicine |
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| author | Fabio Scarinci Francesca Romana Patacchioli Cristina Mihaela Ghiciuc Vittorio Pasquali Raluca Mihaela Bercea Sebastian Cozma Mariacristina Parravano |
| author_facet | Fabio Scarinci Francesca Romana Patacchioli Cristina Mihaela Ghiciuc Vittorio Pasquali Raluca Mihaela Bercea Sebastian Cozma Mariacristina Parravano |
| author_sort | Fabio Scarinci |
| collection | DOAJ |
| description | Obstructive sleep apnea (OSA) and central serous chorioretinopathy (CSC) are in terms of nosography different pathologies, however they share a stress-related physio-pathogenetic component, not yet explored in depth. Therefore, the aim of the present study was to ascertain whether OSA and CSC share a common profile, specifically in cortisol production focusing on the cortisol awake response (CAR), the area under curve (AUC<sub>CAR</sub>) and the SLOPE<sub>CAR</sub> compared with healthy matched controls. Furthermore, standardized self-administered questionnaires were used to identify mental health status related to depression, anxiety and subjective stress perception levels in the study populations. The results showed hypothalamus-pituitary-adrenal (HPA) axis activity anomalies, represented by a flattening CAR in the OSA group and a statistically significant increase in cortisol production in CSC patients at awakening. This disarrangement of the HPA axis activity associated with elevated distress and mental health scores, and its presence in both patients with OSA and patients with CSC, might represent the shared path explaining the stress-related component in these diseases. Further research is needed to investigate the psycho-neuro-endocrinological aspects of OSA and CSC to determine whether psychoeducation on effective stress coping strategies might be of value in improving the quality of life of OSA and CSC patients. |
| first_indexed | 2024-03-10T18:00:05Z |
| format | Article |
| id | doaj.art-76ae9afbdb8141f09df09385e7864681 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T18:00:05Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-76ae9afbdb8141f09df09385e78646812023-11-20T08:54:47ZengMDPI AGJournal of Clinical Medicine2077-03832020-08-0198249010.3390/jcm9082490Psychological Profile and Distinct Salivary Cortisol Awake Response (CAR) in Two Different Study Populations with Obstructive Sleep Apnea (OSA) and Central Serous Chorioretinopathy (CSC)Fabio Scarinci0Francesca Romana Patacchioli1Cristina Mihaela Ghiciuc2Vittorio Pasquali3Raluca Mihaela Bercea4Sebastian Cozma5Mariacristina Parravano6IRCCS—Fondazione Bietti, 00100 Rome, ItalyIRCCS—Fondazione Bietti, 00100 Rome, ItalyDepartment of Pharmacology, School of Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, 700115 Iaşi, RomaniaDepartment of Psychology, Sapienza University of Rome, 00100 Rome, ItalyDepartment of Pneumology, County Emergency Hospital of Ploieşti, 100248 Ploieşti, RomaniaDepartment of Otorhinolaryngology, School of Medicine, University of Medicine and Pharmacy “Grigore T. Popa”, 700115 Iasi, RomaniaIRCCS—Fondazione Bietti, 00100 Rome, ItalyObstructive sleep apnea (OSA) and central serous chorioretinopathy (CSC) are in terms of nosography different pathologies, however they share a stress-related physio-pathogenetic component, not yet explored in depth. Therefore, the aim of the present study was to ascertain whether OSA and CSC share a common profile, specifically in cortisol production focusing on the cortisol awake response (CAR), the area under curve (AUC<sub>CAR</sub>) and the SLOPE<sub>CAR</sub> compared with healthy matched controls. Furthermore, standardized self-administered questionnaires were used to identify mental health status related to depression, anxiety and subjective stress perception levels in the study populations. The results showed hypothalamus-pituitary-adrenal (HPA) axis activity anomalies, represented by a flattening CAR in the OSA group and a statistically significant increase in cortisol production in CSC patients at awakening. This disarrangement of the HPA axis activity associated with elevated distress and mental health scores, and its presence in both patients with OSA and patients with CSC, might represent the shared path explaining the stress-related component in these diseases. Further research is needed to investigate the psycho-neuro-endocrinological aspects of OSA and CSC to determine whether psychoeducation on effective stress coping strategies might be of value in improving the quality of life of OSA and CSC patients.https://www.mdpi.com/2077-0383/9/8/2490salivary cortisolAUC<sub>CAR</sub>SLOPE<sub>CAR</sub>obstructive sleep apnea (OSA)central serous chorioretinopathy (CSC)Daily Hassles and Stress (DHS) questionnaire |
| spellingShingle | Fabio Scarinci Francesca Romana Patacchioli Cristina Mihaela Ghiciuc Vittorio Pasquali Raluca Mihaela Bercea Sebastian Cozma Mariacristina Parravano Psychological Profile and Distinct Salivary Cortisol Awake Response (CAR) in Two Different Study Populations with Obstructive Sleep Apnea (OSA) and Central Serous Chorioretinopathy (CSC) Journal of Clinical Medicine salivary cortisol AUC<sub>CAR</sub> SLOPE<sub>CAR</sub> obstructive sleep apnea (OSA) central serous chorioretinopathy (CSC) Daily Hassles and Stress (DHS) questionnaire |
| title | Psychological Profile and Distinct Salivary Cortisol Awake Response (CAR) in Two Different Study Populations with Obstructive Sleep Apnea (OSA) and Central Serous Chorioretinopathy (CSC) |
| title_full | Psychological Profile and Distinct Salivary Cortisol Awake Response (CAR) in Two Different Study Populations with Obstructive Sleep Apnea (OSA) and Central Serous Chorioretinopathy (CSC) |
| title_fullStr | Psychological Profile and Distinct Salivary Cortisol Awake Response (CAR) in Two Different Study Populations with Obstructive Sleep Apnea (OSA) and Central Serous Chorioretinopathy (CSC) |
| title_full_unstemmed | Psychological Profile and Distinct Salivary Cortisol Awake Response (CAR) in Two Different Study Populations with Obstructive Sleep Apnea (OSA) and Central Serous Chorioretinopathy (CSC) |
| title_short | Psychological Profile and Distinct Salivary Cortisol Awake Response (CAR) in Two Different Study Populations with Obstructive Sleep Apnea (OSA) and Central Serous Chorioretinopathy (CSC) |
| title_sort | psychological profile and distinct salivary cortisol awake response car in two different study populations with obstructive sleep apnea osa and central serous chorioretinopathy csc |
| topic | salivary cortisol AUC<sub>CAR</sub> SLOPE<sub>CAR</sub> obstructive sleep apnea (OSA) central serous chorioretinopathy (CSC) Daily Hassles and Stress (DHS) questionnaire |
| url | https://www.mdpi.com/2077-0383/9/8/2490 |
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