Are Alterations in Skeletal Muscle Mitochondria a Cause or Consequence of Insulin Resistance?
As a major site of glucose uptake following a meal, skeletal muscle has an important role in whole-body glucose metabolism. Evidence in humans and animal models of insulin resistance and type 2 diabetes suggests that alterations in mitochondrial characteristics accompany the development of skeletal...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/18/6948 |
| _version_ | 1797552972311298048 |
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| author | Amanda J. Genders Graham P. Holloway David J. Bishop |
| author_facet | Amanda J. Genders Graham P. Holloway David J. Bishop |
| author_sort | Amanda J. Genders |
| collection | DOAJ |
| description | As a major site of glucose uptake following a meal, skeletal muscle has an important role in whole-body glucose metabolism. Evidence in humans and animal models of insulin resistance and type 2 diabetes suggests that alterations in mitochondrial characteristics accompany the development of skeletal muscle insulin resistance. However, it is unclear whether changes in mitochondrial content, respiratory function, or substrate oxidation are central to the development of insulin resistance or occur in response to insulin resistance. Thus, this review will aim to evaluate the apparent conflicting information placing mitochondria as a key organelle in the development of insulin resistance in skeletal muscle. |
| first_indexed | 2024-03-10T16:09:45Z |
| format | Article |
| id | doaj.art-76af70de527f429fa337300d65778069 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T16:09:45Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-76af70de527f429fa337300d657780692023-11-20T14:37:06ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-09-012118694810.3390/ijms21186948Are Alterations in Skeletal Muscle Mitochondria a Cause or Consequence of Insulin Resistance?Amanda J. Genders0Graham P. Holloway1David J. Bishop2Institute for Health and Sport (iHeS), Victoria University, Melbourne 8001, AustraliaDept. Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, CanadaInstitute for Health and Sport (iHeS), Victoria University, Melbourne 8001, AustraliaAs a major site of glucose uptake following a meal, skeletal muscle has an important role in whole-body glucose metabolism. Evidence in humans and animal models of insulin resistance and type 2 diabetes suggests that alterations in mitochondrial characteristics accompany the development of skeletal muscle insulin resistance. However, it is unclear whether changes in mitochondrial content, respiratory function, or substrate oxidation are central to the development of insulin resistance or occur in response to insulin resistance. Thus, this review will aim to evaluate the apparent conflicting information placing mitochondria as a key organelle in the development of insulin resistance in skeletal muscle.https://www.mdpi.com/1422-0067/21/18/6948mitochondriainsulin resistanceskeletal muscletype 2 diabetesfatty acid oxidationlipid metabolites |
| spellingShingle | Amanda J. Genders Graham P. Holloway David J. Bishop Are Alterations in Skeletal Muscle Mitochondria a Cause or Consequence of Insulin Resistance? International Journal of Molecular Sciences mitochondria insulin resistance skeletal muscle type 2 diabetes fatty acid oxidation lipid metabolites |
| title | Are Alterations in Skeletal Muscle Mitochondria a Cause or Consequence of Insulin Resistance? |
| title_full | Are Alterations in Skeletal Muscle Mitochondria a Cause or Consequence of Insulin Resistance? |
| title_fullStr | Are Alterations in Skeletal Muscle Mitochondria a Cause or Consequence of Insulin Resistance? |
| title_full_unstemmed | Are Alterations in Skeletal Muscle Mitochondria a Cause or Consequence of Insulin Resistance? |
| title_short | Are Alterations in Skeletal Muscle Mitochondria a Cause or Consequence of Insulin Resistance? |
| title_sort | are alterations in skeletal muscle mitochondria a cause or consequence of insulin resistance |
| topic | mitochondria insulin resistance skeletal muscle type 2 diabetes fatty acid oxidation lipid metabolites |
| url | https://www.mdpi.com/1422-0067/21/18/6948 |
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