A new predictor of in-stent restenosis in patients undergoing elective percutaneous coronary İntervention: triglyceride glucose İndex
Objective: This study aimed to investigate whether triglyceride glucose (TyG) index predicts the development of in-stent restenosis (ISR) in patients undergoing percutaneous coronary intervention (PCI) for de novo lesions. Materials and Methods: This was a prospective case controlled study and inclu...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2021-01-01
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| Series: | International Journal of the Cardiovascular Academy |
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| Online Access: | http://www.ijcva.com/article.asp?issn=2405-8181;year=2021;volume=7;issue=2;spage=50;epage=54;aulast=Kalyoncuoglu |
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| author | Muhsin Kalyoncuoglu Alev Arat Ozkan Aysem Kaya Yasin Yuksel Nafi Dogan Aziz Tevfik Gurmen |
| author_facet | Muhsin Kalyoncuoglu Alev Arat Ozkan Aysem Kaya Yasin Yuksel Nafi Dogan Aziz Tevfik Gurmen |
| author_sort | Muhsin Kalyoncuoglu |
| collection | DOAJ |
| description | Objective: This study aimed to investigate whether triglyceride glucose (TyG) index predicts the development of in-stent restenosis (ISR) in patients undergoing percutaneous coronary intervention (PCI) for de novo lesions. Materials and Methods: This was a prospective case controlled study and includes 124 patients with a mean age of 57 ± 9.1. Control coronary angiography was performed in all patients enrolled in the study 6–12 months after the PCI. Blood sample triglycerides (TGs) and blood glucose concentrations were collected after at least 8 h of fasting. The TyG index was calculated as follows: log (serum TGs [mg/dL] × plasma glucose [mg/dL]/2). The study cohort was divided into two groups as those with and without restenosis. Angiographically, stent restenosis, defined as the presence of ≥50% diameter narrowing either within the stent or within 5 mm proximally or distally to the stent margin. Results: The median follow-up time was 7.17 months (±2.01). Forty-eight patients (38.7%) had restenosis. Patients with ISR had more diabetes (P < 0.01) and CAD (P = 0.03). These also had higher TyG index (P = 0.04) and less drug-eluting stent implantation (P = 0.04). Diabetes (odds ratio [OR]: 1.927, P = 0.03), stent type (OR: 0.342, P = 0.02), and TyG index (OR: 4.144, P = 0.01) significantly predicted ISR. The receiver operating characteristics curve analysis revealed a cutoff value of TyG index >4.71 predicts the development of ISR. Conclusion: A TyG above 4.71 was found a risk factor for ISR during 1-year follow-up period after index elective PCI. |
| first_indexed | 2024-03-12T05:36:29Z |
| format | Article |
| id | doaj.art-76b0298973ff432c85c4a2040d5557c9 |
| institution | Directory Open Access Journal |
| issn | 2405-8181 2405-819X |
| language | English |
| last_indexed | 2024-03-12T05:36:29Z |
| publishDate | 2021-01-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | International Journal of the Cardiovascular Academy |
| spelling | doaj.art-76b0298973ff432c85c4a2040d5557c92023-09-03T06:21:51ZengGalenos Publishing HouseInternational Journal of the Cardiovascular Academy2405-81812405-819X2021-01-0172505410.4103/ijca.ijca_15_21A new predictor of in-stent restenosis in patients undergoing elective percutaneous coronary İntervention: triglyceride glucose İndexMuhsin KalyoncuogluAlev Arat OzkanAysem KayaYasin YukselNafi DoganAziz Tevfik GurmenObjective: This study aimed to investigate whether triglyceride glucose (TyG) index predicts the development of in-stent restenosis (ISR) in patients undergoing percutaneous coronary intervention (PCI) for de novo lesions. Materials and Methods: This was a prospective case controlled study and includes 124 patients with a mean age of 57 ± 9.1. Control coronary angiography was performed in all patients enrolled in the study 6–12 months after the PCI. Blood sample triglycerides (TGs) and blood glucose concentrations were collected after at least 8 h of fasting. The TyG index was calculated as follows: log (serum TGs [mg/dL] × plasma glucose [mg/dL]/2). The study cohort was divided into two groups as those with and without restenosis. Angiographically, stent restenosis, defined as the presence of ≥50% diameter narrowing either within the stent or within 5 mm proximally or distally to the stent margin. Results: The median follow-up time was 7.17 months (±2.01). Forty-eight patients (38.7%) had restenosis. Patients with ISR had more diabetes (P < 0.01) and CAD (P = 0.03). These also had higher TyG index (P = 0.04) and less drug-eluting stent implantation (P = 0.04). Diabetes (odds ratio [OR]: 1.927, P = 0.03), stent type (OR: 0.342, P = 0.02), and TyG index (OR: 4.144, P = 0.01) significantly predicted ISR. The receiver operating characteristics curve analysis revealed a cutoff value of TyG index >4.71 predicts the development of ISR. Conclusion: A TyG above 4.71 was found a risk factor for ISR during 1-year follow-up period after index elective PCI.http://www.ijcva.com/article.asp?issn=2405-8181;year=2021;volume=7;issue=2;spage=50;epage=54;aulast=Kalyoncuogluglucose indexglucoserestenosistriglycerides |
| spellingShingle | Muhsin Kalyoncuoglu Alev Arat Ozkan Aysem Kaya Yasin Yuksel Nafi Dogan Aziz Tevfik Gurmen A new predictor of in-stent restenosis in patients undergoing elective percutaneous coronary İntervention: triglyceride glucose İndex International Journal of the Cardiovascular Academy glucose index glucose restenosis triglycerides |
| title | A new predictor of in-stent restenosis in patients undergoing elective percutaneous coronary İntervention: triglyceride glucose İndex |
| title_full | A new predictor of in-stent restenosis in patients undergoing elective percutaneous coronary İntervention: triglyceride glucose İndex |
| title_fullStr | A new predictor of in-stent restenosis in patients undergoing elective percutaneous coronary İntervention: triglyceride glucose İndex |
| title_full_unstemmed | A new predictor of in-stent restenosis in patients undergoing elective percutaneous coronary İntervention: triglyceride glucose İndex |
| title_short | A new predictor of in-stent restenosis in patients undergoing elective percutaneous coronary İntervention: triglyceride glucose İndex |
| title_sort | new predictor of in stent restenosis in patients undergoing elective percutaneous coronary intervention triglyceride glucose index |
| topic | glucose index glucose restenosis triglycerides |
| url | http://www.ijcva.com/article.asp?issn=2405-8181;year=2021;volume=7;issue=2;spage=50;epage=54;aulast=Kalyoncuoglu |
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