Research progress on the effects and mechanisms of anesthetics on neural stem cells
Abstract Exposure to anesthetic drugs has been proven to seriously affect developing animals in terms of neural stem cells' (NSCs') proliferation, differentiation, and apoptosis. This can severely hamper the development of physiological learning and memory skills. Studies on the effects of...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2022-12-01
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| Series: | Ibrain |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ibra.12071 |
| _version_ | 1811198442585718784 |
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| author | Ji Zhang Quan‐Yuan Chang Loris Rizzello You Wu |
| author_facet | Ji Zhang Quan‐Yuan Chang Loris Rizzello You Wu |
| author_sort | Ji Zhang |
| collection | DOAJ |
| description | Abstract Exposure to anesthetic drugs has been proven to seriously affect developing animals in terms of neural stem cells' (NSCs') proliferation, differentiation, and apoptosis. This can severely hamper the development of physiological learning and memory skills. Studies on the effects of anesthetics on NSCs' proliferation and differentiation are thus reviewed here, with the aim to highlight which specific drug mechanisms are the least harmful to NSCs. PubMed has been used as the preferential searching database of relevant literature to identify studies on the effects and mechanisms of NSCs' proliferation and differentiation. It was concluded that propofol and sevoflurane may be the safest options for NSCs during pregnancy and in pediatric clinical procedures, while dexmedetomidine has been found to reduce opioid‐related damage in NSCs. It was also found that the growth environment may impact neurodevelopment even more than narcotic drugs. Nonetheless, the current scientific literature available further highlights how more extensive clinical trials are absolutely required for corroborating the conclusion drawn here. |
| first_indexed | 2024-04-12T01:31:51Z |
| format | Article |
| id | doaj.art-76b32051f2924387b8a564e6c3ba0f8a |
| institution | Directory Open Access Journal |
| issn | 2769-2795 |
| language | English |
| last_indexed | 2024-04-12T01:31:51Z |
| publishDate | 2022-12-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Ibrain |
| spelling | doaj.art-76b32051f2924387b8a564e6c3ba0f8a2022-12-22T03:53:28ZengWiley-VCHIbrain2769-27952022-12-018445346410.1002/ibra.12071Research progress on the effects and mechanisms of anesthetics on neural stem cellsJi Zhang0Quan‐Yuan Chang1Loris Rizzello2You Wu3Department of Anesthesiology Southwest Medical University Luzhou ChinaDepartment of Anesthesiology Southwest Medical University Luzhou ChinaDepartment of Pharmaceutical Sciences University of Milan Milan ItalyDepartment of Family Planning The Affiliated Hospital of Zunyi Medical University Guizhou Zunyi ChinaAbstract Exposure to anesthetic drugs has been proven to seriously affect developing animals in terms of neural stem cells' (NSCs') proliferation, differentiation, and apoptosis. This can severely hamper the development of physiological learning and memory skills. Studies on the effects of anesthetics on NSCs' proliferation and differentiation are thus reviewed here, with the aim to highlight which specific drug mechanisms are the least harmful to NSCs. PubMed has been used as the preferential searching database of relevant literature to identify studies on the effects and mechanisms of NSCs' proliferation and differentiation. It was concluded that propofol and sevoflurane may be the safest options for NSCs during pregnancy and in pediatric clinical procedures, while dexmedetomidine has been found to reduce opioid‐related damage in NSCs. It was also found that the growth environment may impact neurodevelopment even more than narcotic drugs. Nonetheless, the current scientific literature available further highlights how more extensive clinical trials are absolutely required for corroborating the conclusion drawn here.https://doi.org/10.1002/ibra.12071anesthesiadevelopmentdrugsneural stem cells |
| spellingShingle | Ji Zhang Quan‐Yuan Chang Loris Rizzello You Wu Research progress on the effects and mechanisms of anesthetics on neural stem cells Ibrain anesthesia development drugs neural stem cells |
| title | Research progress on the effects and mechanisms of anesthetics on neural stem cells |
| title_full | Research progress on the effects and mechanisms of anesthetics on neural stem cells |
| title_fullStr | Research progress on the effects and mechanisms of anesthetics on neural stem cells |
| title_full_unstemmed | Research progress on the effects and mechanisms of anesthetics on neural stem cells |
| title_short | Research progress on the effects and mechanisms of anesthetics on neural stem cells |
| title_sort | research progress on the effects and mechanisms of anesthetics on neural stem cells |
| topic | anesthesia development drugs neural stem cells |
| url | https://doi.org/10.1002/ibra.12071 |
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