H2O2-preconditioned human adipose-derived stem cells (HC016) increase their resistance to oxidative stress by overexpressing Nrf2 and bioenergetic adaptation

H2O2-preconditioned human adipose-derived stem cells (HC016) increase their resistance to oxidative stress by overexpressing Nrf2 and bioenergetic adaptation

Abstract Background Mesenchymal stem cells, including those derived from human adipose tissue (hASCs), are currently being widely investigated for cell therapy. However, when transplanted at the site of injury, the survival and engraftment rates of hASCs are low, mainly due to the harsh microenviron...

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Bibliographic Details
Main Authors: Patricia Garrido-Pascual, Ana Alonso-Varona, Begoña Castro, María Burón, Teodoro Palomares
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Stem Cell Research & Therapy
Subjects:
Human adipose-derived stem cells
H2O2 preconditioning
Oxidative stress
Nrf2
Bioenergetic
Cell therapy
Online Access:http://link.springer.com/article/10.1186/s13287-020-01851-z

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