Immune system and tumor microenvironment in early-stage breast cancer: different mechanisms for early recurrence after mastectomy and chemotherapy on ductal and lobular types [version 2; peer review: 2 approved]
Background: The most common type of breast cancer is the ductal type (IDC), followed by lobular type (ILC). Surgery is the main therapy for early-stage breast cancer. Adjuvant chemotherapy might be given to those at high risk of recurrence. We aimed to determine the mechanisms in early local recurre...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Sprog: | English |
| Udgivet: |
F1000 Research Ltd
2023-09-01
|
| Serier: | F1000Research |
| Fag: | |
| Online adgang: | https://f1000research.com/articles/12-841/v2 |
| _version_ | 1827617143302127616 |
|---|---|
| author | Desak Gede Agung Suprabawati Hari Basuki Notobroto I Ketut Sudiana Andreas Andrianto |
| author_facet | Desak Gede Agung Suprabawati Hari Basuki Notobroto I Ketut Sudiana Andreas Andrianto |
| author_sort | Desak Gede Agung Suprabawati |
| collection | DOAJ |
| description | Background: The most common type of breast cancer is the ductal type (IDC), followed by lobular type (ILC). Surgery is the main therapy for early-stage breast cancer. Adjuvant chemotherapy might be given to those at high risk of recurrence. We aimed to determine the mechanisms in early local recurrence in both types. Methods: An observational case-controlled study was used. Early-stage IDC and ILC patients who received modified radical mastectomy (MRM) and adjuvant taxan and anthracycline base chemotherapy had recurrence within two years. We examined vimentin, α-smooth muscle actin (SMA), matrix metalloproteinase (MMP1), platelet-derived growth factor (PDGF), and clustered differentiation (CD95) Results: In the ductal type group, there were 25 samples revealing local recurrence and 25 samples that did not recur. The lobular type group comprised six participants who did not have a recurrence, while seven subjects had a recurrence. There were significant differences in the expression of vimentin (p = 0.000 and 0.021, respectively), PDGF (p = 0.000 and 0.002), and CD95 (p = 0.000 and 0.045) in ductal and lobular cancer types, respectively. MMP1 (p = 0.000) and α-SMA (p = 0.000) only showed a significant difference in the ductal type. The pathway analysis showed that in the ductal type, the mechanism of recurrence was enabled by two factors: α-SMA and CD95. Meanwhile, for the lobular type, the recurrence mechanism was through the CD95 pathway. Conclusions: The tumor microenvironment and immune system both affect recurrence in IDC, whereas the immune system is more important in ILC. This study suggests that immune system enhancement may be an option for treating cancer. |
| first_indexed | 2024-03-09T09:39:49Z |
| format | Article |
| id | doaj.art-76b4a1b5c3004843ad3cfd81f1ad4795 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-03-09T09:39:49Z |
| publishDate | 2023-09-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-76b4a1b5c3004843ad3cfd81f1ad47952023-12-02T01:00:00ZengF1000 Research LtdF1000Research2046-14022023-09-0112156682Immune system and tumor microenvironment in early-stage breast cancer: different mechanisms for early recurrence after mastectomy and chemotherapy on ductal and lobular types [version 2; peer review: 2 approved]Desak Gede Agung Suprabawati0Hari Basuki Notobroto1I Ketut Sudiana2Andreas Andrianto3https://orcid.org/0009-0006-4880-1669Division of Oncology, Department of Surgery, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60132, IndonesiaDepartment of Biostatistics and Population, Faculty of Public Health, Universitas Airlangga, Surabaya, East Java, 60132, IndonesiaDepartment of Pathology Anatomy, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60132, IndonesiaDoctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 60132, IndonesiaBackground: The most common type of breast cancer is the ductal type (IDC), followed by lobular type (ILC). Surgery is the main therapy for early-stage breast cancer. Adjuvant chemotherapy might be given to those at high risk of recurrence. We aimed to determine the mechanisms in early local recurrence in both types. Methods: An observational case-controlled study was used. Early-stage IDC and ILC patients who received modified radical mastectomy (MRM) and adjuvant taxan and anthracycline base chemotherapy had recurrence within two years. We examined vimentin, α-smooth muscle actin (SMA), matrix metalloproteinase (MMP1), platelet-derived growth factor (PDGF), and clustered differentiation (CD95) Results: In the ductal type group, there were 25 samples revealing local recurrence and 25 samples that did not recur. The lobular type group comprised six participants who did not have a recurrence, while seven subjects had a recurrence. There were significant differences in the expression of vimentin (p = 0.000 and 0.021, respectively), PDGF (p = 0.000 and 0.002), and CD95 (p = 0.000 and 0.045) in ductal and lobular cancer types, respectively. MMP1 (p = 0.000) and α-SMA (p = 0.000) only showed a significant difference in the ductal type. The pathway analysis showed that in the ductal type, the mechanism of recurrence was enabled by two factors: α-SMA and CD95. Meanwhile, for the lobular type, the recurrence mechanism was through the CD95 pathway. Conclusions: The tumor microenvironment and immune system both affect recurrence in IDC, whereas the immune system is more important in ILC. This study suggests that immune system enhancement may be an option for treating cancer.https://f1000research.com/articles/12-841/v2Ductal Carcinoma Lobular Carcinoma Local Recurrence Early Breast Carcinomaeng |
| spellingShingle | Desak Gede Agung Suprabawati Hari Basuki Notobroto I Ketut Sudiana Andreas Andrianto Immune system and tumor microenvironment in early-stage breast cancer: different mechanisms for early recurrence after mastectomy and chemotherapy on ductal and lobular types [version 2; peer review: 2 approved] F1000Research Ductal Carcinoma Lobular Carcinoma Local Recurrence Early Breast Carcinoma eng |
| title | Immune system and tumor microenvironment in early-stage breast cancer: different mechanisms for early recurrence after mastectomy and chemotherapy on ductal and lobular types [version 2; peer review: 2 approved] |
| title_full | Immune system and tumor microenvironment in early-stage breast cancer: different mechanisms for early recurrence after mastectomy and chemotherapy on ductal and lobular types [version 2; peer review: 2 approved] |
| title_fullStr | Immune system and tumor microenvironment in early-stage breast cancer: different mechanisms for early recurrence after mastectomy and chemotherapy on ductal and lobular types [version 2; peer review: 2 approved] |
| title_full_unstemmed | Immune system and tumor microenvironment in early-stage breast cancer: different mechanisms for early recurrence after mastectomy and chemotherapy on ductal and lobular types [version 2; peer review: 2 approved] |
| title_short | Immune system and tumor microenvironment in early-stage breast cancer: different mechanisms for early recurrence after mastectomy and chemotherapy on ductal and lobular types [version 2; peer review: 2 approved] |
| title_sort | immune system and tumor microenvironment in early stage breast cancer different mechanisms for early recurrence after mastectomy and chemotherapy on ductal and lobular types version 2 peer review 2 approved |
| topic | Ductal Carcinoma Lobular Carcinoma Local Recurrence Early Breast Carcinoma eng |
| url | https://f1000research.com/articles/12-841/v2 |
| work_keys_str_mv | AT desakgedeagungsuprabawati immunesystemandtumormicroenvironmentinearlystagebreastcancerdifferentmechanismsforearlyrecurrenceaftermastectomyandchemotherapyonductalandlobulartypesversion2peerreview2approved AT haribasukinotobroto immunesystemandtumormicroenvironmentinearlystagebreastcancerdifferentmechanismsforearlyrecurrenceaftermastectomyandchemotherapyonductalandlobulartypesversion2peerreview2approved AT iketutsudiana immunesystemandtumormicroenvironmentinearlystagebreastcancerdifferentmechanismsforearlyrecurrenceaftermastectomyandchemotherapyonductalandlobulartypesversion2peerreview2approved AT andreasandrianto immunesystemandtumormicroenvironmentinearlystagebreastcancerdifferentmechanismsforearlyrecurrenceaftermastectomyandchemotherapyonductalandlobulartypesversion2peerreview2approved |