Immunophenotypic and Molecular Features of Acute Myeloid Leukemia with Plasmacytoid Dendritic Cell Differentiation Are Distinct from Blastic Plasmacytoid Dendritic Cell Neoplasm

Immunophenotypic and Molecular Features of Acute Myeloid Leukemia with Plasmacytoid Dendritic Cell Differentiation Are Distinct from Blastic Plasmacytoid Dendritic Cell Neoplasm

Acute myeloid leukemia (AML) with ≥2% plasmacytoid dendritic cells (pDC) has been recently described as AML with pDC differentiation (pDC-AML) characterized by pDC expansion with frequent <i>RUNX1</i> mutations. In this study, we investigated a cohort of 53 pDC-AML cases representing abo...

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Bibliographic Details
Main Authors: Wei Wang, Jie Xu, Joseph D. Khoury, Naveen Pemmaraju, Hong Fang, Roberto N. Miranda, C. Cameron Yin, Siba El Hussein, Fuli Jia, Zhenya Tang, Shimin Hu, Marina Konopleva, L. Jeffrey Medeiros, Sa A. Wang
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cancers
Subjects:
acute myeloid leukemia
BPDCN
plasmacytoid dendritic cells
immunophenotype
flow cytometry
mutation
Online Access:https://www.mdpi.com/2072-6694/14/14/3375

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