Assessment of Nephroprotective role of Irbesartan against gentamicin induced nephrotoxicity in rats
Aims of study : The present study was undertaken to assess the renoprotective effect of irbesartan on gentamicin induced nephrotoxicity in male rats. Materials and methods: Fifteen male adult Sprague-Dawely rats were enrolled in this study, rats were separated randomly into 3 groups, five rats...
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| Format: | Article |
| Language: | English |
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Faculty of Veterinary Medicine, University of Kufa
2012-12-01
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| Series: | Kufa Journal for Veterinary Medical Sciences |
| Online Access: | https://journal.uokufa.edu.iq/index.php/kjvs/article/view/3948 |
| _version_ | 1827389077210529792 |
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| author | Fadaa A. Ghafil Fatimah A. Al-Zubaidi Seher A. Almedeny |
| author_facet | Fadaa A. Ghafil Fatimah A. Al-Zubaidi Seher A. Almedeny |
| author_sort | Fadaa A. Ghafil |
| collection | DOAJ |
| description |
Aims of study : The present study was undertaken to assess the renoprotective effect of irbesartan on gentamicin induced nephrotoxicity in male rats.
Materials and methods: Fifteen male adult Sprague-Dawely rats were enrolled in this study, rats were separated randomly into 3 groups, five rats in each group, the first group maintained on normal standard chow diet, served as control group. The second group received gentamicin 100 mg/kg/day, i.p for 4 weeks. The third group received gentamicin 100mg/kg/day i.p concomitantly with irbesartan 25 mg/kg/day p.o for 4 weeks.
Results: Gentamicin treatment increased serum urea, creatinine and tissue malondialdehyde (MDA) significantly. Irbesartan treatment decreased serum urea, creatinine and tissue MDA significantly.
Conclusion: Gentamicin induced nenephrotoxicity can be prevented by coadministration with irbesartan.
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| first_indexed | 2024-03-08T16:29:21Z |
| format | Article |
| id | doaj.art-76b5c9d4748e45519d2014c0adb8e9dd |
| institution | Directory Open Access Journal |
| issn | 2077-9798 2959-8478 |
| language | English |
| last_indexed | 2024-03-08T16:29:21Z |
| publishDate | 2012-12-01 |
| publisher | Faculty of Veterinary Medicine, University of Kufa |
| record_format | Article |
| series | Kufa Journal for Veterinary Medical Sciences |
| spelling | doaj.art-76b5c9d4748e45519d2014c0adb8e9dd2024-01-06T10:24:57ZengFaculty of Veterinary Medicine, University of KufaKufa Journal for Veterinary Medical Sciences2077-97982959-84782012-12-013210.36326/kjvs/2012/v3i23948Assessment of Nephroprotective role of Irbesartan against gentamicin induced nephrotoxicity in ratsFadaa A. GhafilFatimah A. Al-ZubaidiSeher A. Almedeny Aims of study : The present study was undertaken to assess the renoprotective effect of irbesartan on gentamicin induced nephrotoxicity in male rats. Materials and methods: Fifteen male adult Sprague-Dawely rats were enrolled in this study, rats were separated randomly into 3 groups, five rats in each group, the first group maintained on normal standard chow diet, served as control group. The second group received gentamicin 100 mg/kg/day, i.p for 4 weeks. The third group received gentamicin 100mg/kg/day i.p concomitantly with irbesartan 25 mg/kg/day p.o for 4 weeks. Results: Gentamicin treatment increased serum urea, creatinine and tissue malondialdehyde (MDA) significantly. Irbesartan treatment decreased serum urea, creatinine and tissue MDA significantly. Conclusion: Gentamicin induced nenephrotoxicity can be prevented by coadministration with irbesartan. https://journal.uokufa.edu.iq/index.php/kjvs/article/view/3948 |
| spellingShingle | Fadaa A. Ghafil Fatimah A. Al-Zubaidi Seher A. Almedeny Assessment of Nephroprotective role of Irbesartan against gentamicin induced nephrotoxicity in rats Kufa Journal for Veterinary Medical Sciences |
| title | Assessment of Nephroprotective role of Irbesartan against gentamicin induced nephrotoxicity in rats |
| title_full | Assessment of Nephroprotective role of Irbesartan against gentamicin induced nephrotoxicity in rats |
| title_fullStr | Assessment of Nephroprotective role of Irbesartan against gentamicin induced nephrotoxicity in rats |
| title_full_unstemmed | Assessment of Nephroprotective role of Irbesartan against gentamicin induced nephrotoxicity in rats |
| title_short | Assessment of Nephroprotective role of Irbesartan against gentamicin induced nephrotoxicity in rats |
| title_sort | assessment of nephroprotective role of irbesartan against gentamicin induced nephrotoxicity in rats |
| url | https://journal.uokufa.edu.iq/index.php/kjvs/article/view/3948 |
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