Osteopontin as a Biomarker in Chronic Kidney Disease
Osteopontin (OPN) is a ubiquitously expressed protein with a wide range of physiological functions, including roles in bone mineralization, immune regulation, and wound healing. OPN has been implicated in the pathogenesis of several forms of chronic kidney disease (CKD) where it promotes inflammatio...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/5/1356 |
| _version_ | 1827741975843962880 |
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| author | Satyesh K. Sinha Michael Mellody Maria Beatriz Carpio Robert Damoiseaux Susanne B. Nicholas |
| author_facet | Satyesh K. Sinha Michael Mellody Maria Beatriz Carpio Robert Damoiseaux Susanne B. Nicholas |
| author_sort | Satyesh K. Sinha |
| collection | DOAJ |
| description | Osteopontin (OPN) is a ubiquitously expressed protein with a wide range of physiological functions, including roles in bone mineralization, immune regulation, and wound healing. OPN has been implicated in the pathogenesis of several forms of chronic kidney disease (CKD) where it promotes inflammation and fibrosis and regulates calcium and phosphate metabolism. OPN expression is increased in the kidneys, blood, and urine of patients with CKD, particularly in those with diabetic kidney disease and glomerulonephritis. The full-length OPN protein is cleaved by various proteases, including thrombin, matrix metalloproteinase (MMP)-3, MMP-7, cathepsin-D, and plasmin, producing N-terminal OPN (ntOPN), which may have more detrimental effects in CKD. Studies suggest that OPN may serve as a biomarker in CKD, and while more research is needed to fully evaluate and validate OPN and ntOPN as CKD biomarkers, the available evidence suggests that they are promising candidates for further investigation. Targeting OPN may be a potential treatment strategy. Several studies show that inhibition of OPN expression or activity can attenuate kidney injury and improve kidney function. In addition to its effects on kidney function, OPN has been linked to cardiovascular disease, which is a major cause of morbidity and mortality in patients with CKD. |
| first_indexed | 2024-03-11T03:54:47Z |
| format | Article |
| id | doaj.art-76b702ed3c0f436ab97d9577ce5340bb |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T03:54:47Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-76b702ed3c0f436ab97d9577ce5340bb2023-11-18T00:35:50ZengMDPI AGBiomedicines2227-90592023-05-01115135610.3390/biomedicines11051356Osteopontin as a Biomarker in Chronic Kidney DiseaseSatyesh K. Sinha0Michael Mellody1Maria Beatriz Carpio2Robert Damoiseaux3Susanne B. Nicholas4Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USADepartment of Bioengineering, Henry Samueli School of Engineering, University of California, Los Angeles, CA 90095, USADepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USADepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USADepartment of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USAOsteopontin (OPN) is a ubiquitously expressed protein with a wide range of physiological functions, including roles in bone mineralization, immune regulation, and wound healing. OPN has been implicated in the pathogenesis of several forms of chronic kidney disease (CKD) where it promotes inflammation and fibrosis and regulates calcium and phosphate metabolism. OPN expression is increased in the kidneys, blood, and urine of patients with CKD, particularly in those with diabetic kidney disease and glomerulonephritis. The full-length OPN protein is cleaved by various proteases, including thrombin, matrix metalloproteinase (MMP)-3, MMP-7, cathepsin-D, and plasmin, producing N-terminal OPN (ntOPN), which may have more detrimental effects in CKD. Studies suggest that OPN may serve as a biomarker in CKD, and while more research is needed to fully evaluate and validate OPN and ntOPN as CKD biomarkers, the available evidence suggests that they are promising candidates for further investigation. Targeting OPN may be a potential treatment strategy. Several studies show that inhibition of OPN expression or activity can attenuate kidney injury and improve kidney function. In addition to its effects on kidney function, OPN has been linked to cardiovascular disease, which is a major cause of morbidity and mortality in patients with CKD.https://www.mdpi.com/2227-9059/11/5/1356osteopontinN-terminal osteopontinchronic kidney diseasediabetic kidney diseasebiomarker |
| spellingShingle | Satyesh K. Sinha Michael Mellody Maria Beatriz Carpio Robert Damoiseaux Susanne B. Nicholas Osteopontin as a Biomarker in Chronic Kidney Disease Biomedicines osteopontin N-terminal osteopontin chronic kidney disease diabetic kidney disease biomarker |
| title | Osteopontin as a Biomarker in Chronic Kidney Disease |
| title_full | Osteopontin as a Biomarker in Chronic Kidney Disease |
| title_fullStr | Osteopontin as a Biomarker in Chronic Kidney Disease |
| title_full_unstemmed | Osteopontin as a Biomarker in Chronic Kidney Disease |
| title_short | Osteopontin as a Biomarker in Chronic Kidney Disease |
| title_sort | osteopontin as a biomarker in chronic kidney disease |
| topic | osteopontin N-terminal osteopontin chronic kidney disease diabetic kidney disease biomarker |
| url | https://www.mdpi.com/2227-9059/11/5/1356 |
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